Docusate sodium is a colorless or pale yellow liquid that is soluble in water and organic solvents such as benzene and carbon tetrachloride. Wax like solid Dioctyl sulfosuccinate sodium salt is an essential ingredient for treating constipation, usually made into laxatives or stool softeners. Docusate sodium powder can control the release progress of antibiotics and other products, making it a good slow-release ingredient. It is also used in industry to synthesize electrospun fibers. Due to its good permeability and wetting properties, it is also an excellent emulsifier, detergent, and penetrant commonly used in the textile industry. In short, the application of AEROSOL OT powder is very extensive.
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ITEMS |
SPECIFICATIONS |
RESULTS |
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Appearance |
White to almost white,crystalline powder |
White crystalline powder |
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Identification |
The retention time of the sample should match with working standard(HPLC) |
Conforms |
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Water |
≤2.0%w/w |
1.3% |
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Residue on Ignition |
19.0%～23.0%w/w(calculated on the anhydrous basis.) |
21.3% |
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Heavy Metals |
≤10ppm |
<10ppm |
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Arsenic |
≤3ppm |
<3ppm |
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Assay as Docusate Sodium |
≥83.0%,calculated on the anhydrous basis. |
85.2% |
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Assay as sodium benzoate |
≤17.0,calculated on the anhydrous basis. |
15.8% |
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Residual solvents |
Methanol:≤0.3% |
N.D. |
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Isopropanol:≤0.5% |
N.D. |
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2-Ethyl-1-hexanol:≤0.5% |
N.D. |
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Dichloromethane:≤0.6% |
N.D. |
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Conclusion |
This batch of Docusate Sodium 85%meets the specification of In-house. |
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Can constipation be treated with Docusate sodium Tablets for a long time?
The main component of Docusate sodium Tablets is Dioctyl sulfosuccinate sodium salt, which belongs to a kind of anionic surfactant with high molecular weight. After taking it, it can increase the moisture in feces, make feces soft, and thus play a laxative role. At the same time, Docusate sodium powder can also lubricate the intestinal mucosa, promote gastrointestinal peristalsis to a certain extent, and help improve constipation. Therefore, constipation patients can be treated by taking This product for a long time under the guidance of a doctor.
However, it should be noted that this product has a strong diuretic effect. In ordinary use, patients with chronic heart failure or renal insufficiency are likely to get worse, and long-term or high-dose use of docusate sodium is also likely to have adverse effects on kidneys and liver. Therefore, it is necessary to monitor renal function for long-term use to avoid adverse reactions caused by drug accumulation. In addition, due to the central nervous system excitability, if it is used in large quantities for a long time, it may lead to excessive excitement of the sympathetic nervous system, thus preventing you from falling asleep normally.
Which is better, sodium Docusate or lactulose?
Both Docusate sodium and Lactulose Oral Solution can be used for the treatment of constipation, but each has its own advantages. Details are as follows:
1. Different mechanisms of action: Sodium Docusate is an anionic surfactant that acts in the gastrointestinal tract after oral administration. It can promote the penetration of water and fat substances into feces, thereby providing physical lubrication for bowel movements. Its advantage is that the effect comes quickly, making it suitable for patients who need to relieve constipation symptoms quickly. In contrast, lactulose is converted into low molecular weight organic acids in the colon, which stimulate colonic peristalsis and alleviate constipation by increasing fecal volume. The advantage of lactulose is that it is relatively mild and may cause bloating in the early stages of medication, but overall it is relatively safe. And it is available in oral solution form for the treatment and prevention of chronic or habitual constipation, hepatic encephalopathy.
2. Different indications: After using sodium Docusate, adverse reactions such as bloating, abdominal pain, loss of appetite, nausea, diarrhea, etc. may occur, which are relatively irritating. In addition, there is insufficient data on the use of sodium Docusate in pregnant women, and it may be secreted in breast milk, so it is not recommended for pregnant and lactating women to use it; Lactulose, as a commonly used product for chronic or habitual constipation, can not only treat and prevent hepatic encephalopathy (PSE), but also demonstrate good safety and efficacy in the use of pregnant and lactating women.
3. Our choice: In summary, both sodium Docusate and lactulose are effective drugs for treating constipation, but each has its own characteristics. Docusate sodium has a fast effect but strong irritation, suitable for situations that urgently need rapid symptom relief, while lactulose is relatively mild and suitable for long-term use or patients who are sensitive to drug stimulation. Patients should choose drugs that are suitable for themselves based on their actual situation and the doctor's advice,
Our company can provide you with Docusate sodium,polyethylene glycol 4000 and Lactulose at a better price. If you are interested, please contact us by email:sales6@faithfulbio.com
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| 577-11-7 Dioctyl sulfosuccinate sodium salt | 4618-18-2 Lactulose | 25322-68-3 Polyethylene Glycol |
How should we choose sodium Docusate and polyethylene glycol 4000 powder?
As mentioned above, Docusate sodium powder is a surfactant, which softens feces by increasing the water content in the intestine, thus relieving constipation.Polyethylene-glycol 4000 is a kind of osmotic laxative, and its principle of action is basically the same as that of Dioctyl sulfosuccinate sodium salt.It also softens and increases the amount of feces by attracting and retaining water in the intestines, stimulating intestinal peristalsis and aiding in bowel movements.
In the comparative observation, PEG 4000 powder is unlikely to cause electrolyte imbalance and dependence, but Poly(ethylene glycol) 4000 powder is not suitable for everyone, especially those patients with small intestine or colon diseases, intestinal obstruction, intestinal perforation and other diseases should be banned. If you are experiencing constipation, it is recommended to consult a doctor for personalized treatment.
In daily life, the key to prevent and relieve constipation is to maintain healthy living habits, increase dietary fiber intake, maintain adequate water intake, exercise regularly, develop the habit of regular defecation, and avoid excessive exertion when defecating, so as not to cause anal injury or hemorrhoids. If constipation persists or is accompanied by other discomfort, you should seek medical advice promptly.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide low-priced Docusate sodium,polyethylene glycol 4000 and Lactulose for your research and comparison. If you have relevant purchasing plans, please contact us
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
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