Baclofen Powder CAS 1134-47-0

Baclofen powder is an organic compound, which is soluble in hot water. Its aqueous solution is neutral, hardly soluble in ethanol, ether, acetone, and other organic solvents, but easily soluble in acidic and alkaline aqueous solutions. Used as a skeletal muscle relaxant and sedative for the spinal cord.

Density: 1.3±0.1 g/cm3

Boiling point: 364.3±32.0 °C at 760 mmHg

Melting point: 208-210 C.

The molecular formula: C10H12ClNO2

Molecular weight: 213.661

Flash Point: 174.1±25.1 °C

Accuracy: 213.055649

PSA：63.32000

LogP：1.56

Appearance: white powder

Vapor pressure: 0.0±0.9 mmHg at 25°C

Refractive index: 1.577

Storage conditions: sealed and stored at 2 C-8 C.

Stability: If used and stored according to specifications, it will not decompose, and there is no known dangerous reaction, so avoid oxides.

Solubility: 1 M HCl: 50 mg/mL

Baclofen is a derivative of γ -amino acid. It can inhibit the release of excitatory amino acid neurotransmitters, reduce the excitability of spinal monosynaptic and polysynaptic reflex, reduce the release of substance P and calcium influx, and thus relieve myotonia and painful spasm.

What aspects does Baclofen adapt to?

1. Baclofen powder is used for skeletal muscle spasms caused by multiple sclerosis.

2. It is used for spasticity caused by infectious, degenerative, traumatic, tumor, or unexplained spinal cord diseases.

3. It is used for cerebral muscle spasms.

4. It can also be used for urinary retention caused by external sphincter spasms.

How does Baclofen work?

Baclofen powder can activate GABA β receptor, and reduce the reflex potential of single synapse or multiple synapses of the spinal cord, and the reflex potential between the posterior roots of the spinal cord, resulting in skeletal muscle relaxation.

What are the precautions of Baclofen?

1. The symptoms of Baclofen overdose are the most prominent signs of central nervous system inhibition. Severe poisoning is characterized by seizures, coma, respiratory depression, and hypotonia with loss of limb reflexes. Bradycardia and hypotension have also been observed.

2. It is forbidden for those who are allergic to it, with Parkinson's disease, finger spasms, and pregnant women in the first trimester of pregnancy.

3. Patients with hypertension, peptic ulcer, cerebrovascular diseases and respiratory diseases, liver and kidney insufficiency, authors with a history of epilepsy or convulsions, pregnant and lactating women with mental disorders, schizophrenia or confusion, drivers or operators of machines should use it with caution.

4. Epilepsy patients need to control their seizures, and EEG monitoring should be done.

5. Before stopping the drug, it should be reduced one by one to prevent the rebound phenomenon.

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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.

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