Product Introduction
Decitabine powder, also known as 5-aza-2'-deoxycytidine, is a natural adenosine analog of 2'-deoxycytidine. It inhibits DNA methyltransferase and reduces DNA methylation, thereby inhibiting tumor cell proliferation and preventing the occurrence of drug resistance. It is the strongest known DNA methylation-specific inhibitor and an S-phase cell cycle-specific drug suitable for the treatment of myelodysplastic syndrome (MDS).
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| decitabine powder Picture | decitabine powder MF |
Product Application
After decitabine powder is phosphorylated, it exerts its anti-tumor effect. It acts directly on DNA, inhibits DNA methyltransferase, and thus causes DNA hypomethylation and cell differentiation and death. Decitabine inhibits DNA methylation in vitro, but does not affect DNA synthesis. It can cause tumor cells to demethylate and restore the normal function of genes, which is very important for controlling cell differentiation and proliferation. However, non-proliferative cells are insensitive to decitabine.
This article describes method development and method validation of related substances of Decitabine (α- decitabine, α-isomer, methyl 4-chlorobenzoate, β-isomer, OAcetyl and unknown impurities) in decitabine drug substance and finished dosage forms by using a high Performance liquid chromatography. In this high performance liquid chromatography, the resolution was achieved on Inertsil ODS 3V, 250×4.6 mm, 5µm column with a gradient elution at a flow rate of 1.2 mL/min using a mobile phase A as Ammonium acetate buffer solution and mobile phase B as water:
acetonitrile (10:90% v/v) at wavelength 254 nm by an UV detector. The method was validated in the concentration range of 0.7 ppm to 7.1 ppm, 1.2 ppm to 11.0 ppm, 1.2 ppm to 10.9 ppm, 1.2 ppm to 11.0 ppm, 1.2 ppm to 10.9 ppm and 0.8 ppm to 7.7 ppm for related substances of α- decitabine, α-isomer, methyl 4-chlorobenzoate, β-isomer, O-Acetyl and Decitabine respectively. The obtained recovery was in between 90.0 % to 110.0 % and the % RSD was not more than 10.0.
Product Specification
| Items | Standard | Result |
| Appearance | A white to off white powder | Off white powder |
| Identification | A. IR: Sample IR spectrum corresponds with that of the standard | Conforms |
| B. HPLC: The RT of the major peak of the Test solution corresponds to that of the Standard solution | ||
| C: PXRD: Positive | ||
| Loss on drying | NMT 1.0% | 0.002 |
| Heavy metals | NMT 20ppm | <20ppm |
| Sulphated ash | NMT 0.1% | 0.0005 |
| Related substances | α-Decitabine:≤0.15% | 0.0001 |
| Single unknown impuritie:≤0.1% | ND | |
| Total impurities:≤1.0% | 0.0002 | |
| Residual solvents | DMSO:NMT 0.5% | 0.00075 |
| Methanol: NMT 0.3% | 0.00053 | |
| Methyl formate: NMT 0.05% | ND | |
| Acetonitrile: NMT 0.041% | 0.00% | |
| Methyl toluate: NMT 0.05% | ND | |
| Assay(HPLC) | 98.0-102.0%(On the dried basis) | 100.00% |
| Conclusion：Conform with enterprise specification . | ||
How To Obtain Samples decitabine powder?
Welcome to send an inquiry to sunny@faithfulbio.com at any time for a free sample if you need the API decitabine powder.
The Best decitabine powder Manufacturer And Supplier
Faithfulbio has rich experience in exporting raw materials and has established stable and long-term cooperative relations with our customers. We always put product quality and service first. If you have raw material purchasing needs, please contact us. We can confirm the order with you according to your purchase quantity. We also support our first cooperation starting from samples. In addition, our fast and safe transportation also enables you to Eliminate the trouble of customs clearance.
We have confidence in the quality of our products, but if there are any after-sales problems, we will respond as soon as possible and solve them with you in the best way.
Why Choose Faithfulbio decitabine powder?
Faithfulbio specialize in decitabine powder for several years, we supply products at a competitive price, and our product is of the highest quality, because we are very strict in product production and testing, and have a complete and mature system. In addition, our employees The quotation for the product is very competitive.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
kindly note: Use decitabine powder for research purposes only. All compounds have risks. Please consult your doctor and learn about available studies before use. In addition, the above description of the compound comes from online literature. If there is any infringement, please contact us to delete it.
Where To Buy decitabine powder?
Just send an email to sunny@faithfulbio.com, or submit your requirement in the bottom form, we are of service at any time!
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