Omeprazole Powder CAS 73590-58-6

Basic information of omeprazole：

Omeprazole powder is white or white-like crystalline powder; Odorless; easy to change color when exposed to light. Soluble in dichloromethane, slightly soluble in methanol or ethanol, slightly soluble in acetone and insoluble in water; Dissolve in 0.lmol/L sodium hydroxide solution.
Omeprazole is a brand-new anti-peptic ulcer drug whose mechanism of action is different from that of H2 receptor antagonism. It specifically acts on Parietal cells of gastric mucosa, reducing the activity of "Proton pump" in parietal cells, so this kind of drugs is also called "proton pump inhibitor". On June 20, 2003, the US Food and Drug Administration approved omeprazole as an over-the-counter drug in the treatment of frequent heartburn.

CAS：119141-89-8
Molecular formula: C17H19N3O3S.
Molecular weight: 345.41600
Accurate mass: 345.11500
PSA：96.31000
LogP：3.76540
Density: 1.37 g/cm3
Boiling point: 600ºC at 760 mmHg
Flash Point: 316.7ºC
Storage conditions: 2-8c
Melting point: 156 C.
Solubility: solubility in water is 0.5mg/mL.
Form: solid
Acidity coefficient: (PKA) PKA 4.14/8.9 (H2O, t = 25, I = 0.025) (unchecked)
Color: white
Water solubility: soluble in water (0.5 mg/ml), DMSO (25 mg/ml), and ethanol (4.5 mg/ml).
Stability: stable, but hygroscopic and photosensitive. Incompatible with strong oxidant. Keep away from light.

What is Omeprazole?

Omeprazole (H 16868) is a proton pump inhibitor (PPI), which has the potential to be used in the research of gastrointestinal diseases. Omeprazole competitively inhibited the activity of CYP2C19, with a Ki of 2 to 6 μM m. 

Omeprazole powder also inhibits the growth of gram-positive bacteria and gram-negative bacteria. It is an inhibitor of N-SMase (exosome inhibitor).

 

What are the synthetic routes of omeprazole?

 

3,5- dimethyl -2- hydroxymethyl -4- methoxypyridine was chlorinated to produce 2- chloromethyl -3,5- dimethyl -4- methoxypyridine. 4- methoxy 1,2- phenylenediamine reacts with potassium xanthate to generate 2- mercapto -5- methoxybenzimidazole, and then reacts with the pyridine derivative obtained above to generate 2-[(3,5- dimethyl -4- methoxy -2- pyridyl) methylthio ]-5- methoxy -1H- benzimidazole. The crude omeprazole can be recrystallized from acetonitrile.

Structural formula of Omeprazole

Synthesis route 1 of Omeprazole

Synthesis route 2 of Omeprazole

Synthesis route 3 of Omeprazole

Synthesis route 4 of Omeprazole

Synthesis route 5 of Omeprazole

Synthesis route 6 of Omeprazole

Synthesis route 7 of Omeprazole

Synthesis route 1 of Omeprazole References: Syn-Tech Chem. and Pharm. Co., Ltd. Patent: US2009/5570 A1, 2009 ; Location in patent: Page/Page column 3 ;	Synthesis route 2 of Omeprazole References: Quimica Sintetica, S.A. Patent: EP1992619 A1, 2008 ; Location in patent: Page/Page column 15-16 ;	Synthesis route 3 of Omeprazole References: US2007/249662 A1, ; Page/Page column 5 ;	Synthesis route 4 of Omeprazole References: US5948789 A1, ; US 5948789 A
Synthesis route 5 of Omeprazole References: US5948789 A1, ; US 5948789 A	Synthesis route 6 of Omeprazole References: US5948789 A1, ; US 5948789 A	Synthesis route 7 of Omeprazole References: US2011/160156 A1, ;

 

 

Product Specification

Item	Specification	Results
Identification
A:	By TLC	positive
B:	IR Conforms to standard	positive
Completeness of solution	Conforms to standard	positive
Color of solution	The absorbance is not greater than 0.1 at 440nm	0.04
Loss on drying	≤0.5%	0.002
Residue on ignition	≤0.1%	0.0004
Heavy metals	≤0.002%	<0.002%
Chromatographic purity (HPLC)
Single impurity	≤0.3%	0.0012
Total impurity	≤1.0%	0.0028
Residual solvent
a)Acetone	≤ 5000ppm	554ppm
b)Methylene	≤600ppm	12ppm
c)Methanol	≤ 3000ppm	50ppm
d)Toluene	≤ 890ppm	28ppm
Assay(HPLC)	98.0%-99.0%	0.985
Conclusion	The results conform with CP2010

 

HTTML5 atlas of Omeprazole

 

Omeprazole products produced and sold by Faithful are guaranteed in quality. The following is the product atlas, and we look forward to cooperating with you.

What effect does omeprazole have?

1. Omeprazole powder is mainly used for duodenal ulcer and Zhuoai syndrome, and can also be used for gastric ulcer and reflux esophagitis.
2. It is a proton pump inhibitor and a fat-soluble weakly alkaline drug. It is easy to concentrate in acidic environment and transform into active sulfenamide. Through the irreversible combination of disulfide bond and sulfhydryl group of proton pump, the activity of H+ and K+-ATPase is inhibited, and the acid content in gastric juice is greatly reduced.
3. Severe renal insufficiency and infants are prohibited. It is reported that atrophic gastritis has been observed in the stomach biopsy specimens of patients who have used this product for a long time abroad. Long-term use may lead to hypergastrinemia and vitamin B12 deficiency.

 

How does omeprazole work?

Like other proton pump inhibitors, omeprazole can bind to H+/K+-ATPase of gastric parietal cells, inhibit its activity and prevent proton pump from transporting H+ to gastric cavity (the last step of gastric acid production), thus inhibiting gastric acid production. Omeprazole, as a prodrug, is converted into active substance (hyposulfonic acid) through acid secretory tubules of gastric parietal cells. Because the inhibition process is irreversible, gastric acid secretion will be limited in the next 24 to 48 hours until new proton pump molecules are synthesized and transferred to the cell membrane.

 

why reduce the secretion of gastric acid?

Omeprazole powder in the treatment of gastric ulcer is mainly related to its mechanism of inhibiting proton pump and reducing gastric acid secretion. Then why reduce the secretion of gastric acid?

This is because after the formation of gastric ulcer, high concentration of gastric acid stimulates and corrodes the gastric mucosa, which causes continuous damage to the ulcer area and hinders the healing process. This includes three common mechanisms:

1. Stimulation and injury: Gastric acid is a strong acid, which can stimulate and corrode gastric mucosa. When there is gastric ulcer, the ulcer area has been inflamed and damaged, and high concentration of gastric acid will further aggravate this irritation and damage.

2. Inhibit the healing process: The existence of gastric acid will inhibit the healing process of gastric mucosa. Under normal circumstances, gastric mucosal cells have the ability of self-repair and healing, but high concentration of gastric acid may inhibit these repair mechanisms, making it difficult for ulcer areas to heal quickly.

3. Maintain the inflammatory state: Gastric acid can maintain the inflammatory state of gastric mucosa, and inflammation is an important factor in ulcer formation and delayed healing. Inflammation will cause increased blood flow, leading to local edema, exudation and fibrin formation, which may hinder the healing process.

This makes gastric acid a negative effect factor in the period of gastric ulcer, so we can promote the healing of gastric ulcer by reducing the secretion of gastric acid or reducing the stimulation of gastric acid on the ulcer.

 

How and where to buy Omeprazole powder wholesale?

You can trust our order, because we have a good record of selling legal educational drugs.

We conduct independent laboratory tests on all products and then sell them to our respected customers.

 

Send your Inquiry for more details, Click email：allen@faithfulbio.com Now.

 

 

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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.

 

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