What is PGE1?
The main component of PGE1 is Prostaglandin E1(PGE1), which is an efficient bioactive substance secreted by human body. It has a strong vasodilating effect, can inhibit platelet aggregation, and has a strong physiological activity. It is an important substance for regulating cell function. It acts on almost all physiological reactions, is widely distributed in the body, and has a small content. Normal human tissues and cells can be synthesized, and quickly inactivated after local biological action.
Prostaglandin E1 is a biologically active substance widely existing in the body. As a member of prostaglandin family, Prostaglandin E1 is recognized as an endogenous physiologically active substance.
PG is a group of endogenous physiologically active substances with prostanoicacid as the skeleton, which is produced by enzymatic or non-enzymatic transformation with eicosapentaenoic acid as the precursor of biosynthesis. In 1958, two kinds of pure PG crystals were isolated from sheep seminal vesicle for the first time: PGE1 and PGF1α. According to the structure, natural PG can be divided into three groups (PG1, PG2 and PG3) and ten types (PGA, PGB, PGC, PGD, PGE, PGF, PGG, PGH, PGI and PGJ). Six kinds of natural PGs in E and F types, namely PGE1, PGE2, PGE3 and PGF1α+PGF2α+PGF3α, have been studied earliest, and are called primary PGs. A, B, C, D, G, H, I, J and other natural PGs are called secondary PGs. The names and codes of various PGs (such as E, F, etc.) are based on the phenomena observed in early research. PG soluble in ethyl ether is represented by e, that is, PGE;; PG soluble in phosphate solution is denoted by f, that is, PGF. PGA and PGB respectively represent the products generated after PGE is treated with acid or base. PGE1 power is a white or yellowish needle crystal. Mp115-116℃, specific rotation-61.6 (c = 0.56, THF). Crystallization from ethyl acetate-pentane, melting point 115 ~ 116℃. It is easy to lose water at pH < 4 or > 8. [α] 578-61.6 (c = 0.56, tetrahydrofuran). PGE1 is a physiologically active substance which can dilate blood vessels and inhibit platelet aggregation.
| Product name | PGE1 |
| CAS | 745-65-3 |
| Molecular formula | C20H34O5 |
| Molecular weight | 354.49 |
| EINECS Number | 212-017-2 |
| Storage condition | -20°C |
| Melting point | 115-116 °C |
| Solubility | Ethanol: 1 mg/mL |
| Appearance | white or off-white powder |
| Boiling point | 407.69°C (rough estimate) |
| Density | 1.0458 (rough estimate) |
What is the pharmacological action of PGE1?
1. dilate blood vessels and inhibit platelet aggregation.
2. Improve liver circulation, increase oxygen supply, and promote liver metabolism and detoxification.
3. Stabilize hepatocyte membrane, inhibit inflammatory factors and promote hepatocyte regeneration.
Product Specification
| Items | Specification | Results |
| Appearance | White Crystalline Powder | Complies |
| Assay(on the dried basis) | ≥99.0% | 99.50% |
| Identification | Positive Reaction | Positive Reaction |
| Melting point | 114-117°C | 115-116°C |
| Related Substances | ≤1.0% | 0.05% |
| Loss On Drying | ≤0.5% | 0.15% |
| Residue On Ignition | ≤0.1% | 0.02% |
| Chloride | ≤0.014% | <0.014 |
| Heavy Metals | ≤20ppm | <20ppm |
| Clarity Of Solution | Conform To Standard | Complies |
| Microbial Limit | ≤20ppm | <20ppm |
| Conclusion: Conform with USP Standard | ||
What is PGE1 used for?
PGE1 powder has many physiological activities, which are commonly used in the following aspects:
Anti-platelet aggregation: PGE1 can prevent platelet aggregation and thrombosis and is used to treat cardiovascular diseases.
Dilating blood vessels: PGE1 can dilate blood vessels and reduce vascular resistance, and is used to treat hypertension and other cardiovascular diseases.
Protect gastric mucosa: PGE1 can promote the repair and protection of gastric mucosa and is used to treat gastric ulcer and other diseases.
Support pregnancy: PGE1 plays an important role in pregnancy and can be used to treat pregnancy-related diseases.
HTML5 atlas of PGE1
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PGE1 configuration solution concentration reference:
| 1mg | 5mg | 10mg | |
| 1 mM | 2.821 ml | 14.105 ml | 28.21 ml |
| 5 mM | 0.564 ml | 2.821 ml | 5.642 ml |
| 10 mM | 0.282 ml | 1.411 ml | 2.821 ml |
| 5 mM | 0.056 ml | 0.282 ml | 0.564 ml |
What are the differences between PGE1 and PGE2?
The difference between PGE1 and PGE2 lies in different uses, pharmacological effects, components and storage methods.
1. Different uses: PGE1 is mainly suitable for the treatment of patients with erectile dysfunction. PGE2 can be used for induced labor in mid-pregnancy, induced labor in full-term pregnancy, therapeutic abortion and elderly primiparas.
2. Different pharmacological effects: PGE1 can reduce prostaglandin production by inhibiting prostaglandin synthase, dilate blood vessels, lower blood pressure and resist inflammation. However, PGE2 mainly acts on uterine smooth muscle, which makes it contract strongly and can also play an exciting role in pregnant uterus.
3. Different components: In terms of components, PGE1 is the main component, while PGE2 is dinoprostone.
4. Different storage methods: PGE1 needs to be sealed and stored at 2 ~ 8℃, while PGE2 should be sealed in the original aluminum foil package and stored in the freezer at -10℃ to -20℃.
It should be noted that although the above two substances are naturally occurring bioactive substances, there are significant differences in their properties and functions. You should read the instructions carefully before using any medicine.
Where is PGE1 metabolized?
PGE1 is mainly inactivated in the lungs.
PGE1 mainly oxidizes the hydroxyl group at site 15 of alprostadil to keto group through 15- hydroxy deaminase (PGDH), which makes it lose its physiological activity, and then forms metabolic end products through a series of changes.
15- Hydroxydeaminase (PGDH) exists widely in lung, liver, kidney and adipose tissue. It is generally believed that more than 80% of alprostadil is inactivated in lung.
What is the difference between PGE1 targeting and tumor targeting drugs?
PGE1 is passively targeted, and tumor targeting drugs are actively targeted.
When the blood vessels are inflamed, hardened or convulsed, the blood flow changes from normal to abnormal, and alprostadil is easy to deposit in the vascular lesions and exert its drug effect.
What are the precautions of PGE1?
1. Headache, anorexia, diarrhea, hypotension and tachycardia; Local swelling, pain, redness and fever at the acupuncture point.
2. Pregnancy and lactation are prohibited.
3. The liquid medicine must be freshly prepared.
How and where to buy PGE1 Powder wholesale?
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We conduct independent laboratory tests on all products and then sell them to our respected customers.
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure, or prevent any disease.
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