Butylphthalide CAS 6066-49-5
Product Name:3-N-Butylphthalide
Synonym:3-butyl-1(3h)-isobenzofuranon;BUTYLPHTHALIDE, 3-n-(P);3-Butylisobenzofuran-1(3H);CL234;Butylphathlide;Butyphthalide impurity 49;Butylphthalide, 99.95%;Butylphthalide (Natural)
CAS NO.:6066-49-5
EINECS NO.:228-000-8
Molecular Formula:C12H14O2
Purity & Grade: 99%; Medicine grade
Character:liquid
Free sample:Available
Stock:In stock
Warehouse: USA/EU/AU Warehouse
MOQ & Package: 1g; Package according to demand
Shipping: Safe and fast delivery
Lead Time: 5-10 days
Store & Shelf life: Cool & dry place; 24 months
Description
Product description
Butylphthalide is a highly bioactive phthalide compound, a functional active substance with both natural and synthetic value. Under normal conditions, it is a colorless to pale yellow clear oily liquid, possessing unique lipid solubility and poor water immiscibility. Its stable physicochemical properties provide a solid foundation for its application development. Its natural prototype can be extracted and isolated from umbelliferous plants such as celery. The maturity of synthetic techniques has enabled the large-scale preparation of standardized raw materials with high purity and high stability, which are widely used in biological research, functional regulation, microcirculation optimization, and other related fields.
As a typical chiral compound, Butylphthalide contains two stereoconfigurations, with slight differences in bioactivity between the different configurations. Optimized formulations of the racemic and dextrorotatory monomers exhibit superior biocompatibility and efficacy. At the level of biological function regulation, 3-N-Butylphthalide possesses diverse bioactive advantages, effectively optimizing the body's cerebral microcirculation system, dilating cerebral capillaries, clearing local blood flow obstructions, and improving blood and oxygen supply to brain tissues. Meanwhile, this substance possesses excellent antioxidant and anti-damage properties, capable of scavenging free radicals produced by the body's metabolism, reducing oxidative stress damage to brain tissue, inhibiting abnormal cell apoptosis processes, and alleviating local tissue edema.
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COA
| Test Item | Specification | Result |
| Appearance | Colorless to pale yellow clear oily liquid |
Complied |
| Assay(HPLC) | ≥98.0% | 99.21% |
| Refractive Index(20℃) | 1.5180~1.5320 | 1.5245 |
| Specific Gravity(25℃) | 1.0650~1.0700 | 1.0672 |
| Boiling Point(15mmHg) | 177~178℃ | 177.4℃ |
| Single Unknown Impurity | ≤0.30% | 0.12% |
| Total Related Impurities | ≤1.50% | 0.58% |
| Water Content(KF) | ≤0.15% | 0.08% |
| Residual Solvents | Meet ICH Q3C | Complied |
| Heavy Metals(Pb) | ≤10ppm | <2ppm |
| Conclusion | Conform with enterprise specification | |
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Density: 1.1±0.1 g/cm³
Boiling point: 312.8±31.0 °C at 760 mmHg
Molecular formula: C12H14O₂
Molecular weight: 190.238
Flash point: 128.3±22.2 °C
Exact mass: 190.099380
PSA: 26.30000
LogP: 3.08
Mechanism of action of 3-N-Butylphthalide
Improves microcirculation and dilates microvessels: Acts on the smooth muscle of brain microvessels, relieving vasoconstriction, dilating microvessel diameter, optimizing local blood perfusion, clearing obstructed microcirculatory pathways, and improving the efficiency of blood supply and oxygen delivery to brain tissue.
Antioxidant and antagonistic to oxidative stress damage: Clears excess free radicals in the body, reduces the intensity of lipid peroxidation, mitigates free radical damage to brain nerve cell membranes and organelles, and alleviates tissue damage caused by oxidative environment.
Inhibits abnormal cell apoptosis: Regulates multiple apoptosis-related signaling pathways, downregulates the expression of pro-apoptotic factors, increases the level of protective proteins, reduces abnormal programmed cell death of nerve cells under ischemic conditions, and protects the integrity of brain tissue cells.
Regulates blood rheological properties: Inhibits abnormal adhesion and aggregation of blood cells, reduces blood viscosity, optimizes blood flow, reduces local stasis, and assists in improving tissue blood supply from a blood flow perspective.
Reduces tissue edema: Regulates blood-brain barrier permeability, reduces leakage of intravascular fluid into interstitial spaces, alleviates ischemia-induced cerebral edema, and reduces secondary tissue compression damage caused by edema. Protecting mitochondrial function: Stabilizing the mitochondrial structure of nerve cells, maintaining energy synthesis, ensuring the energy supply for the brain tissue's basal metabolism, and preventing cell damage induced by energy deficiency.
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Our Factory
Package
Shipping Methods
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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FAQ
01. Which organelle functions does butylphthalide maintain?
Butylphthalide stabilizes mitochondrial structure, ensures cellular energy production, and maintains normal metabolic function in brain cells.
02. Does 3-N-Butylphthalide have chiral configurations?
Yes, it exists in two chiral configurations: dextrorotatory and levorotatory. The different configurations exhibit different biological activities.
03. Where can I buy Butylphthalide?
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