Azithromycin is unstable without hydrate, and usually exists in the form of monohydrate and dihydrate, of which the dihydrate form is the most stable. Azithromycin dihydrate is a macrolide antibiotic with the molecular formula of C38H76N2O14. Pure azithromycin dihydrate USP is white or almost white crystalline powder.
| Items | Specifications | Results |
| Appearance | White or off-white solid | Complies |
| Identification | NMR | Complies |
| Purity (HPLC) | >99.0% | 99.78% |
| Melting point | 180-182°C | 181.33°C |
| Related substances | <1.0% | 0.22% |
| Individual impurity | <0.1% | 0.08% |
| S-enantiomer | <0.5% | 0.15% |
| Loss on drying | <1.0% | 0.46% |
| Residue on ignition | <0.2% | 0.13% |
| Conclusion： | Passed |
Is azithromycin dry suspension an antibiotic?
The main component of azithromycin dry suspension is azithromycin dihydrate, which belongs to one kind of antibiotics and is one of the raw materials of macrolide antibiotics commonly used in clinic. Therefore, when using this product, we should pay attention to the symptoms of double infection caused by non-sensitive bacteria including fungi, just like other antibiotic preparations. In addition, each bag of finished products usually contains 1.94g of sucrose. Patients with blood sugar control need to pay special attention when using this product. Aluminum-containing antacids may reduce the peak value of azithromycin active ingredients by about 1/4, so we do not recommend using it at the same time. If patients are allergic to azithromycin dry suspension and other macrolide antibiotics, it is forbidden to use this product to avoid unnecessary damage.
What is the difference between azithromycin and amoxicillin?
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| 117772-70-0 Azithromycin dihydrate | 26787-78-0 Amoxicillin |
Azithromycin and amoxicillin are two commonly used antibiotics in clinic, and they are different in product classification, indications and drug resistance.
1. Product classification: Azithromycin belongs to macrolide antibiotics, while amoxicillin belongs to penicillin antibiotics.
2. Indications: Azithromycin has a good effect on mycoplasma infection, and is often used to treat upper respiratory tract infection, skin and soft tissue infection and urinary tract infection caused by Haemophilus influenzae and Mycoplasma pneumoniae. Amoxicillin has a strong effect on gram-negative bacteria and is often used to treat otitis media, sinusitis, tonsillitis, urinary tract infection, bronchitis and other diseases.
3. Drug resistance: Azithromycin has a broad antibacterial spectrum and can be effective against many kinds of bacteria, including gram-positive bacteria, gram-negative bacteria and some Acinetobacter. Amoxicillin mainly has good antibacterial effect on gram-positive bacteria and some gram-negative bacteria. Due to the wide application of antibiotics, some bacteria have developed resistance to amoxicillin, but they are still effective to azithromycin. Therefore, azithromycin can be used as an alternative treatment for amoxicillin in some cases, especially for some drug-resistant gram-positive bacteria infections.
Our company can provide various Azithromycin, amoxicillin etc. If you are interested, please contact us via email:sales6@faithfulbio.com
What is the operating principle of azithromycin?
Azithromycin is one of the subclasses of macrolide antibiotics, which is the first product of nitrogen-containing ester antibiotics.Its main function is to control the protein of bacteria, achieving the goal of inhibiting and killing bacteria. According to the verification of animal in vitro experiments, this product can inhibit bacterial protein synthesis by binding to subunits of 50s ribosomes and hindering bacterial peptide transfer process. Moreover, compared with other macrolide antibiotics such as erythromycin, azithromycin has not been found to have a significant effect on the hepatic cytochrome P450 system, nor has it been found to lose activity by inducing hepatic cytochrome P450 to form cytochrome metabolism complexes.
Does azithromycin dihydrate use hot water?
Azithromycin has many dosage forms, including granules, dry suspensions, dispersible tablets, etc. Among them, granules and dry suspensions can be quickly dissolved in water and need to be taken orally, which is beneficial to the rapid absorption and function of drugs. But be careful not to take it with boiling water, which will destroy the ingredients of the medicine and affect its efficacy. Generally, warm water is used to take it.
In addition, azithromycin dihydrate USP has great irritation to the gastrointestinal tract, so it is recommended to take it with water at 30-40℃ 1 hour before or 2 hours after meals to reduce gastrointestinal discomfort. If you have any uncomfortable symptoms after taking the medicine, you should immediately stop using it and see a doctor, improve the relevant examination, cooperate with the doctor's treatment, take it according to the doctor's advice or change other medicines to avoid delaying the illness.
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Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Can provide you with a good price.Our company can provide various Azithromycin, amoxicillin etc. If you are interested, please contact us
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