Cetilistat Raw Powder CAS 282526-98-1

Cetilistat Raw Powder also known as ATL-962, was developed by Alizyme company in the UK. Later, Norina BV company obtained the global agency right of cetilistat. Cetiriestat is in phase 3 clinical trials in the United States. In Japan, due to cooperation with Takeda pharmaceutical, Cetilistat has been approved as a drug for the treatment of obesity in September 2013. The trade name is Olean. It is a drug or food compound for treating obesity. Its mechanism of action is similar to the listed drug orlistat (scenic / Roche fresh / let you cool), which is achieved by inhibiting pancreatic lipase. It is a new gastrointestinal lipase inhibitor, and pancreatic lipase is an enzyme that decomposes triglycerides in the intestine (GI). Without this enzyme, triglycerides in the diet can prevent food nutrients from being hydrolyzed to absorbable free fatty acids and excrete food nutrients that have not been absorbed. The operating mechanism of Cetilistat belongs to the peripheral nervous system.

What's the status of Cetilistat's experiment?

Cetilistat Raw Powder has completed phase 1 and phases 2 drug trials in the United States, phase 3 is still in clinical trials, and it is still a food compound in the United States in 2013. In Japan, due to cooperation with the Takeda pharmaceutical industry, the phase 1 drug clinical trial was started in 2003, followed by the phase 2 drug trial, and the phase 3 trial was started in 2008. All three-stage drug trials were completed in 2012 and a new drug application was submitted to the Japanese government. The Japanese government approved Cetilistat as a drug for the treatment of obesity in September 2013. On September 20, 2013, Takeda pharmaceutical announced that the drug name of Cetilistat was Olean. After Alizyme was found to be the agent of Alizyme in the UK, the company obtained the right of Alizyme for Norgina BV in the world. In human trials, Cetilistat has been shown to produce a weight loss function similar to orlistat; But it also has similar side effects, such as greasy, loose stool (loose stool), fecal incontinence, frequent defecation, flatulence, and so on. It should also be noted that the absorption of fat-soluble vitamins and other fat-soluble nutrients may also be inhibited, so an appropriate amount of vitamins should be supplemented to avoid these deficiencies.

What is the pharmacological action of Cetilistat?

Cetilistat Raw Powder is a long-acting and powerful specific gastrointestinal lipase inhibitor. It plays a therapeutic role by forming covalent bonds with the active serine sites of gastric lipase and pancreatic lipase in the stomach and small intestine to inactivate the enzyme. The inactivated enzyme cannot hydrolyze the fat in food, mainly triglycerides, into absorbable free fatty acids and Monoacylglycerides, Undigested triglycerides cannot be absorbed by the body, so as to reduce calorie intake and control weight. The biggest advantage is that it does not act on the nervous system, does not affect other enzyme activities of the gastrointestinal tract, is not absorbed, that is, it does not enter the blood, does not inhibit appetite, and there is no need to restrict diet. The phenomenon of defecation with oil (a large number of oil droplets floating on the water surface) can appear 24 hours after medication, that is, undigested fat can be excluded. The mechanism of action of Cetilistat is similar to that of Roche's Xenical (orlistat), but compared with the latter, it has much fewer adverse reactions such as incontinence and flatulence. It is safer and better tolerated than Cetilistat.

What is the market situation of drugs orlistat and cetilistat?

The characteristics of different fields will make their market conditions different. Sometimes even the two products with similar effects will have different performances. There is an obvious market difference between cetilistat and orlistat, which are specific drugs in the weight loss industry. Because cetilistat takes product effect as the core, it has invested a lot in R & D and innovation. Generally, the cost of a new drug is mostly R & D cost, and even those long-standing generic drugs still account for a certain share of production cost, Because of this, the overall trend of cetilistat price is to maintain a certain limit of decline. However, orlistat has the opposite performance. For pharmaceutical enterprises and consumers, orlistat's products are not in the first place. The brand and social influence of its products occupy the core position. Many people buy orlistat only because others say it is a famous brand product. Therefore, in order to maintain the influence of the brand, pharmaceutical enterprises will increase marketing investment, and the huge marketing investment will affect the specific distribution proportion of the final product cost.

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