Azathioprine API Powder CAS 446-86-6

Azathioprine Introduction

Azathioprine API Powder is a pale yellow powder, practically insoluble in water. CAS: 446-86-6; Molecular Formula: C9H7N7O2S; Molecular Weight: 277.26; EINECS: 207-175-4. It is primarily synthesized chemically and is used in organ transplantation, autoimmune diseases, as well as in scientific research and animal experiments. 

What is the mechanism of action of Azathioprine?

Azathioprine API Powder is a precursor that, upon entering the physiological system, is converted into an active metabolite, exerting its biological effects through two pathways. On one hand, the generated active substance inhibits the synthesis of ribonucleic acid and proteins, limiting the proliferation and differentiation of various immune cells. On the other hand, it targets and blocks the activation of key intracellular signaling pathways, downregulates the expression of anti-apoptosis-related genes, switches immune cell activation signals to apoptosis signals, and promotes the programmed death of target immune cells. These two mechanisms work together to regulate the body's immune levels.

What is the purpose of Fondaparinux sodium N-4?

Azathioprine can regulate the body's overactive immune response and is widely used in experimental research on various autoimmune-related physiological abnormalities, including rheumatoid arthritis, lupus, Crohn's disease and ulcerative colitis, autoimmune liver injury, pemphigus, and immune thrombocytopenic purpura, to improve damage caused by abnormal immunity and slow disease progression. In liver, kidney, and heart allogeneic tissue transplantation experiments, it is often combined with other immunomodulatory materials to reduce rejection of transplanted tissues.

For refractory cases where conventional experimental protocols have limited effectiveness, Azathioprine API Powder can also be used as an alternative experimental material, applicable to studies of refractory chronic urticaria, severe atopic dermatitis, sarcoidosis, polymyositis, and dermatomyositis. In actual use, the formulation should be flexibly adjusted based on sample condition, experimental benefits and potential impacts, and alternative materials, combined with periodic indicator monitoring.

MF of Azathioprine

CAS	446-86-6
Molecular formula	C9H7N7O2S
Molecular weight	277.26
EINECS	207-175-4
Melting point	243-244°C
Solubility	Soluble in water
Acidity coefficient	8.2(at 25℃)
Density	1.5379
Boiling point	521.0±60.0 °C

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FAQ: 

Q1:Is Azathioprine a steroid?
Azathioprine is not a steroid. It is a different type of immunomodulatory substance. The two differ in chemical structure, mechanism of action, and long-term side effects.
Q2: How long is it safe to take Azathioprine?
Azathioprin can be a long-term management option for many patients with autoimmune conditions or after organ transplantation, but it is not safe for everyone, so it must be used strictly according to medical advice.
Q3:Does Azathioprine cause weight gain?

Currently, there is no data to suggest that using Azathioprine API Powder will increase weight. If an individual experiences weight gain after use, a comprehensive assessment of their physical condition and the product being used should be taken into account.

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