Nicotinamide mononucleotide powder (NMN powder) plays an important role in the energy generation of human cells, and it participates in the synthesis of NAD (nicotinamide adenine dinucleotide, an important coenzyme for cell energy transformation). NMN, which originally existed in the human body, decreased with age. Earlier experiments proved that NMN powder can increase NAD in various organs of experimental mice, thus inhibiting the aging of nerves and blood vessels, and improving diabetes symptoms.
Osteoporosis caused by glucocorticoid is the most common secondary osteoporosis. It is an important NAD+ intermediate and an effective drug for treating age-related diseases. However, the role of NMN in glucocorticoid-induced osteoporosis and its mechanism is not fully understood. To study the protective effect and mechanism of NMN on dexamethasone-induced osteogenesis inhibition. We can treat bone marrow mesenchymal stem cells with a certain concentration of dexamethasone and found that dexamethasone can reduce the levels of osteogenic markers alkaline phosphatase, runt-related transcription factor 2(Runx2), and OCN. Treatment with pure NMN can alleviate dexamethasone-induced osteogenic differentiation inhibition, SIRT1, and peroxisome proliferator-activated receptor coactivator -1α(PGC-1α). Knockout SIRT1 can reverse the protective effect of NMN powder China on osteogenic differentiation and reduce the expression level of PGC-1α. In a word, pure NMN can alleviate glucocorticoid-induced osteogenesis inhibition by up-regulating the SIRT1/PGC-1α signaling pathway, and NMN powder China may be a potential treatment for glucocorticoid-induced osteoporosis.
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| Real shot pictures of NMN powder | NMN structure diagram |
Product Application
1. Nicotinamide mononucleotide powder (NMN powder) repairs DNA and activates longevity protein.
2. It helps to reverse aging.
3. It can prevent diabetes.
4. It enhances endurance.
5. It can increase the cognition of nerves.
6. It can prevent the occurrence of cardiovascular diseases.
7. It also has the function of relieving hangovers and protecting the liver.
8. It can protect eyesight and hearing.
9. It can also regulate the secretion of insulin.
Product Specification
Item | Specification | Results |
Appearance | White to off-white crystalline powder | Conforms |
Water content | ≤5.0% | 0.18% |
Purity (HPLC) | ≥98% | 99.40% |
Ethanol (GC) | ≤2.0% | 0.01% |
Salmonella | N.D | N.D |
Heavy Metal | ||
Arsenic | ≤1ppm | Conforms |
Lead | ≤1ppm | Conforms |
Cadmium | ≤1ppm | Conforms |
Microbial limit | ||
Total aerobic microbial count | ≤750CFU/g | Conforms |
E. Coli | ≤2MPN/g | N.D |
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A variety of shipping methods for you to choose
Transportation Time | Shipping method | Cargo weight requirements | Advantage |
3-7 days | DHL,Germany DHL,Germany DPD, | Suitable for under 50kg. | We have warehouses in Germany and California, the USA, |
7-15 days | By Air | Suitable for more than 50kg. | |
15-60 days | By Sea | Suitable for more than 500kg. |
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.
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