API Powder Detomidine Hcl CAS 90038-01-0
Product Name: API powder Detomidine hcl
CAS NO.: 90038-01-0
Molecular Formula:C12H15ClN2
EINECS.NO:202-303-5
Synonym:1H-Imidazole, 5-[(2,3-dimethylphenyl)methyl]-, hydrochloride; 4-(2,3-Dimethylbenzyl)-1H-imidazole hydrochloride (1:1);DTMT.HCl
Shipping:DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea etc
Store & Shelf life:Cool & dry place;36 months
Other:There are warehouses in the United States, Australia and Germany
Description
what is API powder Detomidine hcl ?
API powder Detomidine hcl is a highly selective α 2-adrenergic receptor agonist,whichbelongs Imidazole derivatives, it's right-handed isomer (S-enantiomer) in their molecular structure endows them with high biological activity, it is a kind of white or off white crystalline powders.
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Product name |
Detomidine hcl |
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CAS |
90038-01-0 |
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Molecular formula |
C12H15ClN2 | |
| EINECS | 202-303-5 | |
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Molecular weight |
222.7139 | |
| Melting point | 160°C | |
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Appearance |
white powder |
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| Storage | Sealed in dry,Room Temperature |
What are the main uses of API powder Detomidine hcl?
Raw materials for formulation production
As an active ingredient, it is used in the preparation of clinical preparations such as injections and tablets, such as sedation before surgical anesthesia, postoperative pain management, or sedation therapy for critically ill patients.
preclinical research
Used for laboratory research to explore its pharmacological effects (such as central sedative and peripheral sympathetic nervous system inhibitory effects of alpha 2 adrenergic receptor agonists) and potential new indications.
Drug development and quality control
As a standard or reference substance, it is used for new drug development, production process optimization, and drug quality testing (such as content determination, impurity analysis).
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Application in veterinary field As a raw material in veterinary medicine, it is used for sedation before animal anesthesia or postoperative analgesia (in accordance with veterinary drug standards). Research materials Used for academic research in fields such as neuroscience, pharmacology, etc., to study their effects on the autonomic nervous system or their interactions with other drugs.If you need it, pls click e-mail sales1@faithfulbio.com |
Product Specification
| Items | Specification | Results |
| Appearance | White or off-white solid powder | Complies |
| Identification | By IR | Complies |
| By HPLC | Complies | |
| Solubility | Soluble in DMF, sparingly soluble in THF,insoluble in water | Complies |
| Polymorphic Form | Polymorphic form 1 | Complies |
| Melting Point | 211ºC~216ºC | 212.8ºC~214.9ºC |
| Water Content | ≤ 0.50% | 0.10% |
| Heavy Metals | ≤ 20ppm | Complies |
| Residue on Ignition | ≤ 0.20% | 0.09% |
| Related Substance | Any single impurity: ≤0.10% | 0.06% |
| Total Impurities: ≤1.00% | 0.16% | |
| Assay (on the anhydrous basis) | 98.0%~102.0% | 99.94% |
| Particle Size | D90: ≤100µm | Complies |
| Conclusion：Conform with enterprise specification | ||
how API powder Detomidine hcl works
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API powder Detomidine hcl binds to and activates α2-catecholamine receptors, which inhibits the release of excitatory neurotransmitters, resulting in reduced sympathetic nervous system activity. Dexmedetomidine hydrochloride can affect alpha 2 adrenergic receptors, especially receptors in the locus coeruleus of the brain. The locus coeruleus is the "headquarters" that regulates wakefulness and stress responses. When the drug binds to the receptor, it inhibits the release of norepinephrine and reduces neural excitability, as if installing an "intelligent dimmer switch" on the brain: autonomously and gently dimming the light, allowing the patient to enter a "awakenable sedative state". This means that patients can cooperate with instructions during surgery, but after surgery, they almost forget the tension of the surgical process. Effects: This action leads to sedation, analgesia (pain relief), muscle relaxation, and can also affect heart rate and breathing. |
How and where to API powder Detomidine hcl?
We have 8 years of experience in selling legal scientific research drugs and have a good reputation, making us a trustworthy partner.
We ensure the quality of our products through independent experimental testing, and every customer is our VIP.
Send your Inquiry for more information, Click email：sales1@faithfulbio.comNow.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
FAQ
Q: Where is the strength of Detomidine hydrochloride?
A:Although the patient is calm, they are easily awakened, reducing the risk of respiratory depression and making it safer;
Can reduce the dosage of other postoperative analgesics, lower the incidence of nausea and vomiting, and provide more comfort;
By stabilizing the sympathetic nervous system, reducing tachycardia and hypertension caused by surgical stress, it is heart friendly.
Q:Is Detomidine Hcl safe?
A:It has a wide safety range and no respiratory inhibition characteristics, making it more advantageous in critically ill patients. But there are also side effects such as hypotension and bradycardia (which can be relieved by adjusting the dosage); Patients with severe heart block and hypotension should avoid using it.
Q: Can I purchase in small doses?
A:We support low-dose testing with a minimum order quantity of 10g.
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Note: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.
Send your Inquiry for more details, Click email：sales1@faithfulbio.com Now.
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