What is Urolithin A?
It has been reported that the substance Urolithin A in pomegranate and other fruits may help to slow down the specific aging process by improving the function of cell mitochondria. In addition, ingestion of this compound poses no risk to human health. Studies have shown that Urolithin A can stimulate the biogenesis of mitochondria in the same way as regular exercise, and it is the only compound that can rebuild the cell's recycling of defective mitochondria.
Urolithin A can be dissolved in strong polar organic solvents such as dimethyl sulfoxide, N,N- dimethylformamide, but it is poorly soluble in low polar petroleum ether and ether and poorly soluble in water.
Urolithin A powder is yellow or light yellow powder. Urolithin A is the intestinal microbial metabolite of ellagic acid, which has the characteristics of anti-inflammatory, anti-proliferation and anti-oxidation. It can be used as an organic synthesis, biochemical intermediate and cell biochemical reagent, and can be applied to the modification and derivatization of drug molecules and bioactive molecules.
| Product name | Urolithin A |
| CAS | 1143-70-0 |
| Molecular formula | C13H8O4 |
| Molecular weight | 228.2 |
| EINECS Number | 1592732-453-0 |
| Storage condition | 2-8°C |
| Melting point | 340-345 °C |
| Solubility | Soluble in DMSO (slight) and methanol (very slight) |
| Appearance | Yellow powder |
| Boiling point | 527.9±43.0 °C(Predicted) |
| Density | 1.516±0.06 g/cm3(Predicted) |
What are the benefits of Urolithin A?
1. Helps lose weight
Urolithin A can not only protect muscles, but the latest research has found that Urolithin A can actually affect cellular lipid metabolism and lipogenesis.
It can reduce triglyceride accumulation and fatty acid oxidation, as well as the expression of genes related to lipogenesis.
2. Urolithin A activates mitochondrial autophagy
Urolithin A's protection against muscle loss was only recently discovered. Previous studies on it have focused on mitochondria, especially mitochondrial autophagy. (Mitochondrial autophagy refers to the selective removal of damaged mitochondria through autophagosomes)
Urolithin A can activate mitochondrial autophagy through various pathways, such as activating enzymes that promote mitochondrial autophagy, or regulating mitochondrial autophagy pathways, and promoting autophagosome formation.
3. Anti-inflammatory effect
More and more literature has found that Urolithin A can fight aging, and it may be another anti-aging artifact. .
We cannot stop ourselves from getting old, but we can improve the speed of aging, especially mitochondrial function and body health.
Improve mitochondria, fight muscle loss, and achieve true aging without aging.
Product Specification
| Item | Specification | Results |
| Appearance | Light grey powder | Conforms |
| Identification | 1HNMR confirms to structure | Conforms |
| LCMS | LCMS confirms to MW | Conforms |
| Water | ≤0.5% | 0.31% |
| Purity(HPLC) | ≥98.0% | 99.08% |
| Pb | ≤0.5ppm | Conforms |
| As | ≤1.5ppm | Conforms |
| Cd | ≤0.5ppm | Conforms |
| Hg | ≤0.1ppm | Conforms |
| Methanol | ≤3000ppm | Not detected |
| TBME | ≤1000ppm | Not detected |
| Toluene | ≤890ppm | Not detected |
| DMSO | ≤5000ppm | 3040ppm |
| Acetic Acid | ≤5000ppm | 1890ppm |
| Conclusion:The product conforms withenterprise standard and qualified. | ||
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What is the bioavailability of Urolithin A related to?
The most important thing is the composition of the microbiome, because not all microbial species can produce it.
The raw material of Urolithin A powder is ellagitannins obtained from food. This precursor is easy to obtain and is almost ubiquitous in nature.
Ellagitannins are hydrolyzed in the intestine to release ellagic acid, which is further processed into Urolithin A by the intestinal flora.
As for which intestinal bacteria synthesize Urolithin A in particular? Unfortunately, there is no clear conclusion.
According to a study in the journal Cell, only 40% of people can naturally convert the precursor into usable Urolithin A.
HTML5 atlas of Urolithin A
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Urolithin A Biological Activity:
| Describe | Urolithin A is an intestinal metabolite of ellagic acid with antioxidant and antiproliferative effects; it inhibits the growth of T24 and Caco-2 cells with IC50 values of 43.9 and 49 μM, respectively. |
| In vitro studies | Urolithin A can mainly inhibit the growth of prostate cancer and colon cancer cells. Urolithin A increases the mRNA and protein expression of Phospho-p38 MAPK and decreases the mRNA and protein expression of MEKK1 and Phospho-c-Jun in T24 cells. Caspase-3 is also activated and PPAR-γ protein expression is increased in drug-induced apoptosis. Urolithin A exerts dose- and time-dependent significant arrest in G2/M and S phases after 50 and 100 μM treatment at 24 and 48 h compared with control cells. It induces apoptosis at 50 and 100 μM. Urolithin A shows potent antiproliferative activity against HepG2 cells. When Urolithin A induces cell death, the expression of β-catenin, c-Myc and cyclin D1 is decreased and TCF/LEF transcriptional activation is significantly downregulated. Urolithin A also increased the protein expression of p53, p38-MAPK and caspase-3, but inhibited the expression of NF-κBp65 and other inflammatory mediators. |
| In vivo studies | Paw edema volume was reduced 1 hour after oral administration of Urolithin A. In addition, the plasma of treated mice showed a significant oxygen radical antioxidant capacity (ORAC) score, and high levels of unbound form of A in plasma 1 hour after oral administration of Urolithin A |
| Cell experiments | Human colon cancer cells HT-29 were treated with 100 and 50 μM Urolithin A and Iso Urolithin A aglycone and its glucuronide conjugates for 24 and 48 h. Cell viability and proliferation were measured using a TC10 automated cell counter, with the addition of trypan blue for viability assays. IC50 values were determined by MTT assay. |
| Animal experiments | Mice: Paw edema was induced in the right hind paw of ICR mice by subcutaneous injection of 1% λ-carrageenan in normal saline (50 μL). The level of inflammation was quantified by the amount of paw edema. Urolithin A dissolved in 0.5% carboxymethylcellulose suspension was orally administered to mice 1 or 6 h before carrageenan injection. The anti-inflammatory effect of Urolithin A on carrageenan-induced edema in mice was analyzed. |
| References |
[1]. Qiu Z, et al. In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells. Food Chem Toxicol. 2013 Sep;59:428-37. [2]. González-Sarrías A, et al. Antiproliferative activity of the ellagic acid-derived gut microbiota isourolithin A and comparison with its urolithin A isomer: the role of cell metabolism.Eur J Nutr. 2017 Mar;56(2):831-841. [3]. Wang Y, et al. In vitro antiproliferative and antioxidant effects of urolithin A, the colonic metabolite of ellagic acid, on hepatocellular carcinomas HepG2 cells. Toxicol In Vitro. 2015 Aug;29(5):1107-15. [4]. Ishimoto H, et al. In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5901-4. |
How and where to buy Urolithin A powder wholesale?
You can trust our order because we have a good record of selling legal educational drugs.
We conduct independent laboratory tests on all products and then sell them to our respected customers.
A variety of shipping methods for you to choose
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Suitable for more than 500kg. |
Send your Inquiry for more details,Click email ：allen@faithfulbio.com Or WhatsApp：+86 13137770562
FAQ：
Q1: What is the core cell repair mechanism of Urolithin A?
A1: It can activate the mitochondrial autophagy pathway, clear damaged and aging mitochondrial structures, and remodel the cellular energy metabolism system.
Q2: How does it work in terms of anti-oxidation and anti-aging?
A2: It can reduce cellular oxidative stress levels, neutralize excess free radicals, and reduce the aging effects of oxidative damage on body tissues.
Q3: What positive physiological regulation does Urolithin A produce on muscle tissue?
A3: It maintains muscle cell vitality through mitochondrial repair mechanisms, delays skeletal muscle function decline, and improves physical endurance and cellular health.
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure, or prevent any disease.
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