Adapalene Powder CAS 106685-40-9
Product Name:Adapalene;Adapalen;Differi;Differin
CAS NO.:106685-40-9
Molecular formula：C28H28O3
Purity & Grade: 99% HPLC; Medicine grade
MOQ & Package: 100g; Package according to demand
Shipping: Safe and fast delivery
Store & Shelf life: Cool & dry place; 24 months
Lead Time: 1-3 days
Warehouse: USA and Germany warehouse
Certificate:COA; HPLC; MSDS; TDS,etc.
Description
What is Adapalene?
Adapalene powder is a white or off-white powder chemical. It is insoluble in water or ethanol, but slightly soluble in tetrahydrofuran. Adapalene belongs to the retinoid class of drugs, which can promote the dissolution of keratin and inhibit the reproduction of Propionibacterium acnes. It has a stable chemical structure and is not easily dissolved in gas or sunlight. Extensive studies in small animals and human sciences have shown no phototoxicity or photosensitivity. However, the safety factor of adapalene in animals and humans repeatedly exposed to sunlight or ultraviolet radiation is still unknown.
| Product name | Adapalene |
| CAS | 106685-40-9 |
| Molecular formula | C28H28O3 |
| Molecular weight | 412.52 |
| EINECS Number | 620-513-9 |
| Storage condition | 2-8°C |
| Melting point | 319-3220 °C |
| Solubility | Dimethyl sulfoxide: > 10mg/mL |
| Appearance | White to off-white powder |
| Boiling point | 606.3±55.0 °C(Predicted) |
| Density | 1.233±0.06 g/cm3(Predicted) |
What is the pharmacological action of adapalene?
The mechanism of Adapalene powder is the same as retinoic acid, which can bind to specific retinoic acid nuclear receptor, but the difference is that adapalene does not bind to protein-bound cytoplasmic receptor. The skin medication test in the animal model established by mice proved that adapalene can treat acne, and it also has an effect on acne vulgaris and differentiation process. The mechanism of action is to reduce the formation of micro acne by making the cells on hair follicles differentiate normally. In the standard anti-inflammatory analysis in vivo and in vitro, adapalene has better efficacy than retinoic acid, which can inhibit the chemotaxis of human polynuclear leukocytes, and inhibit the metabolism of fine pao in polymorphonuclear portal by inhibiting the transformation of arachidonic acid into inflammatory mediators through lipid oxidation, thus alleviating the inflammatory reaction mediated by cell reaction.
Product Specification
| Item | Specification | Results |
| Appearance | White or off-white crystalline powder | Off-white crystalline powder |
| Identification | By IR | Complies |
| RT under chirality should complies | Complies | |
| Chloride: it gives a reaction of chloride | Complies | |
| Water | 3.0%~4.5% | 3.40% |
| Melting Point- | 198.0~202.0ºC | 199.8~200.5ºC |
| Residue on Ignition | ≤0.2% | 0.08% |
| Heavy Metals | ≤10ppm | Complies |
| Related Substances | Individual Impurities:≤0.5% | 0.15% |
| Total Impurities:≤1.0% | 0.22% | |
| Residual Solvent | ≤0.06% | 0.01% |
| ≤0.5% | 0.02% | |
| ≤0.5% | 0.00% | |
| E.E | ≥99.0% | 99.60% |
| Assay (on dry basis) | 98.0%~102.0% | 101.20% |
| Conclusion:It complies to prescribed enterprise standard. | ||
What does adapalene do?
1. Regulate keratinocyte differentiation: Adapalene powder can bind to the acidic core protein of cells, regulate the differentiation and keratinization process of keratinocytes by affecting the structure and function of the intercellular matrix. This effect can reduce the excessive proliferation and nested keratinization near the hair follicle opening, which helps to improve acne lesions.
2. Inhibit keratin accumulation: Adapalene can inhibit keratin accumulation, promote the metabolism and shedding of the stratum corneum, thereby reducing the blockage of the hair follicle opening.
3. Anti-inflammatory effect: Adapalene has a certain anti-inflammatory effect, which can reduce the inflammatory response and thus alleviate the symptoms of inflammatory acne.
HTML5 atlas of Adapalene
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What is Adapalene used for?
1. Treatment of acne: Adapalene is one of the effective products for the treatment of acne, which can improve facial lesions such as acne, papules, and pustules. It can reduce abnormal proliferation and accumulation of keratin, regulate the differentiation of keratinocytes, reduce the blockage and infection of hair follicles, and reduce the formation of acne and acne.
2. Reduce the recurrence of acne: Adapalene can maintain the normal state of the skin for a long time and reduce the recurrence of acne. It can promote the normal differentiation and keratinization of stratum corneum cells, reduce the blockage of hair follicles, and reduce the recurrence rate of acne lesions.
3. Repair skin: Adapalene powder can improve the structural and pigment abnormalities caused by inflammation and promote the repair and regeneration of the skin. It can reduce erythema and swelling and improve the smoothness and texture of the skin.
What is the difference between isotretinoin and adapalene?
1. Different ingredients: The main ingredient of isotretinoin is isotretinoin, while the main ingredient of adapalene is the chemical ingredient adapalene powder. There are also some differences in color. Most of the isotretinoin colors are slightly yellow-green, while most of the adapalene colors are white and translucent.
2. Different adverse reactions: The adverse reactions of isotretinoin are more obvious, which may cause dryness and edema of the skin and mucous membranes, and in severe cases may even cause birth defects. Therefore, isotretinoin is prohibited for women during lactation and pregnancy. Generally speaking, isotretinoin is only used when other conventional treatments are ineffective. The main adverse reaction of adapalene is skin irritation.
3. Different indications: Isotretinoin is mainly suitable for the treatment of severe acne and nodular cystic acne. Adapalene is mainly suitable for the treatment of common acne with acne and papules as the main manifestations.
What are the precautions of Adapalene powder?
1. Pay attention to the cleaning before using Adapalene powder. Wash the skin gently with mild soap or soap-free cleanser and pat it dry with a soft towel. Do not use irritating or abrasive cleaners, and do not scrub the skin violently, otherwise it will increase the irritation of adapalene to the skin.
2. Do not apply adapalene to sunburned, damaged or eczema-covered skin. Do not apply it until the skin heals.
3. During the use of adapalene, if exposed to avoid contact with eyes, lips, mouth, nasal mucosa, canthus and other mucosal tissues, it should not be applied to patients with very serious acne.
4. When using other vitamin A acid drugs or using "wax" hair removal method, you should avoid using this product for treatment.
How and where to buy adapalene powder wholesale?
You can trust our order because we have a good record of selling legal educational drugs.
We conduct independent laboratory tests on all products and then sell them to our respected customers.
Send your Inquiry for more details, Click email：allen@faithfulbio.com Now.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Send your Inquiry for more details, Click email：allen@faithfulbio.com Now.
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure, or prevent any disease.
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