NADH Powder CAS 606-68-8

Beta nicotinamide adenine dinucleotide disodium is a biologically active form of niacin. Used as a coenzyme for hydrogenases and dehydrogenases. NADH powder appears in many metabolic reactions in cells as a reduced form of nicotinamide adenine dinucleotide (NAD+), playing a central role in cellular energy metabolism and redox reactions. Such as cellular tricarboxylic acid cycle (TCA), lipid beta oxidation, etc. It plays an important role in the metabolism and utilization of nutrients such as sugar, fat, and amino acids. It is also the only substrate for coenzyme I consuming enzymes such as NAD+- dependent ADP ribosyltransferase.

How to better store β - NADH Disodium Salt?

The chemical structure of this product contains components such as nicotinamide, adenine, and ribose, which are connected by phosphate bonds and have high biological activity and chemical stability. Pure beta-nicotinamide adenine dinucleotide disodium is a light yellow powder at room temperature, odorless, and has a certain degree of hygroscopicity. It is soluble in solvents such as water and dimethyl sulfoxide. When in contact with incompatible substances such as strong oxidants, reducing agents, acids, and alkali metals, this product may undergo biochemical reactions and is sensitive to light. If long-term storage of this product is required, it is best to store it in a cool, dry, and dark environment, and protect it with argon gas.

What are the uses of the NADH, disodium salt ?

Beta nicotinamide adenine dinucleotide disodium is a biologically active form of niacin used as a coenzyme for hydrogenases and dehydrogenases. We found that it mainly exists in the reduced form (NADPH) in living cells, and its precursor NAD usually acts as a hydrogen acceptor, forming NADH, which then acts as a hydrogen donor in the respiratory chain to generate two forms, α - NAD and β - NAD. The difference between the two is the configuration of the ribosyl nicotinamide bond. However, studies have shown that β - NAD has biological activity and participates in synthetic reactions.
As mentioned earlier, NADH powder is the only substrate for coenzyme I consuming enzymes such as NAD+- dependent ADP ribosyltransferase. It can decompose coenzyme I (NAD+) as a substrate into ADP ribose and nicotinamide (Nam), and exert different physiological functions in different cells, such as participating in DNA repair, regulating cellular oxidative stress, and other physiological functions.

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What is the effect of this product on health?

When faced with acute trauma, inflammation, hypoxia, radiation, chemical toxins, and other factors, there is a significant increase in free radicals in the body, leading to overexpression of PARP. A large amount of activated PARP will consume coenzyme I (NAD+) in cells, resulting in a deficiency of coenzyme I. When coenzyme I is lacking, metabolic functions in the body are affected, mitochondrial function is inhibited, ATP production is reduced, cellular energy is insufficient, and apoptotic signals are released to activate cell apoptosis. On the other hand, other coenzyme I consuming enzymes are affected, such as inhibition of the SIRT1 signaling pathway and inhibition of cellular function. Exogenous supplementation of NADH powder can effectively restore body levels, enhance tissue and cell antioxidant capacity, inhibit apoptosis signals, restore normal cell function, and inhibit disease progression. For example, in acute inflammation, coenzyme I (NAD) can significantly reduce neutrophil apoptosis in the inflammatory response and prolong neutrophil survival time.

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