Sorafenib Powder CAS 284461-73-0

what is Sorafenib Powder?

Sorafenib is a new molecular targeted therapy drug. It is an oral multi-target and multi kinase inhibitor that can target serine/threonine kinases and receptor tyrosine kinases on tumor cells and tumor blood vessels. Sorafenib Powder can inhibit receptor tyrosine kinases KIT and FLT-3, as well as serine/threonine kinases in the Raf/MEK/ERK pathway, significantly inhibiting tumor cell proliferation; On the other hand, by upstream inhibition of receptor tyrosine kinases VEGFR and PDG-FR, and downstream inhibition of serine/threonine kinases in the Raf/MEK/ERK pathway, tumor angiogenesis is significantly inhibited; It can achieve dual effects of anti angiogenesis and anti-tumor cell proliferation with one stone and two birds. anti-tumor cell proliferation with one stone and two birds.

	Product name	Sorafenib
	CAS	284461-73-0
	Molecular formula	C21H16ClF3N4O3
	Molecular weight	464.82
	EINECS Number	608-209-4
	Storage condition	Sealed in dry,Store in freezer, under -20°C
	Appearance	white powder
	Melting point	202-204℃

What are the pharmacological effects of Sorafenib Powder?

Sorafenib Powder is a multi kinase inhibitor. Preclinical studies have shown that sorafenib can simultaneously inhibit multiple kinases present both inside and on the cell surface, including RAF kinase, vascular endothelial growth factor receptor-2 (VEGF-2), vascular endothelial growth factor receptor-3 (VEGF-3), platelet-derived growth factor receptor - β (PDGFR - β), KIT, and FLT-3. From this, it can be seen that sorafenib has a dual anti-tumor effect. On the one hand, it can directly inhibit tumor growth by inhibiting the RAF/MEK/ERK signaling pathway; On the other hand, it can indirectly inhibit the growth of tumor cells by blocking the formation of tumor neovascularization by inhibiting VEGFR and PDGFR.

 

How to treat advanced liver cancer?

The incidence rate of liver cancer is about 20 per 100000. Since the early symptoms of liver cancer are not obvious, nearly 80% of patients are in advanced stage when they go to see a doctor. Half of the world's liver cancer occurs in China. Among the primary factors causing liver cancer in China, hepatitis B ranks first. This causative factor is also very different from liver cancer in Europe and the United States. Researchers from multiple countries have published a report in the latest issue of the New England Journal of Medicine, stating that they conducted a study on 602 patients with advanced liver cancer in countries and regions such as the United States, Europe, and Australia. These patients have not received systematic treatment. The research results found that compared to taking a placebo, takingSorafenib Powder can prolong the overall survival of patients with advanced liver cancer or primary liver cancer by about 44% and delay disease progression by 73%.

The new research results show that Sorafenib Powder, as a new option for treating liver cancer, can prolong the survival of patients, which is "encouraging". Duogemei is produced by Bayer Healthineers in Germany and can act on both tumor cells and tumor blood vessels simultaneously. Researchers introduced at the annual meeting of the American Society of Clinical Oncology last year that they conducted a study on advanced liver cancer patients in the Asia Pacific region and found that Doxorubicin can prolong the survival of these patients by about 47%, making it the only drug proven to significantly prolong the overall survival of advanced liver cancer patients.If you have same need,Click email：sales1@faithfulbio.com

 

Product Specification

Analysis tests	Standard	Results
Appearance	Pale Yellow or almost white crystalline powder	Conforms
Solubility	Soluble in DMSO at 200mg/ml;very poorly soluble in ethanol;very poorly in water.	Conforms
	(1) MS
Identification	(2) UV	Conforms
	(3) 1H-NMR
Loss on drying	≤0.5%	0.26%
Heavy metals	≤10ppm	Conforms
Ordinary impurities	Single impurity≤0.5%	0.11%
	Total impurities≤1.0%	0.3%
Assay(HPLC)	99.0％～101.0％	99.7%

Conclusion：Conform with specification and qualified.

 

Does Sorafenib Powder have any side effects?

The following side effects may occur: common bleeding, gastrointestinal bleeding, respiratory bleeding, and a few may be life-threatening. Common symptoms include nausea, vomiting, diarrhea, fatigue, skin reactions on hands and feet, hair loss, decreased lymphocytes, increased lipase and amylase, and hypophosphatemia. Occasional itching, anorexia and constipation, mild to moderate hypertension, sensory neuropathy, anemia, neutropenia and thrombocytopenia, transient elevation of transaminase. Rare hypertensive crisis. Acute pancreatitis is not common.

 

How is Sorafenib Powder synthesized?

(1)Adding carbonyl chloride 2 to 4-chloro-3-trifluoromethylaniline 1 in the reaction vessel, adding an organic solvent and an acid binding agent, stirring well and maintaining the temperature to a certain temperature, and reacting to form 4-chloro-3. -(Trifluoromethyl)phenyl-N-1-chloro-carboxamide 3; (2)Mixing 4-chloro-3-(trifluoromethyl)phenyl-N-1-chloro-carboxamide 3 obtained in the step (1) with 4-aminophenol 4, and then adding an organic solvent and an acid binding agent for stirring , the reaction occurs at a certain temperature, after the end of the reaction, the stirring is stopped to obtain 4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenol 5; (3)4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenol 5 obtained in the step (2) is added to (4-hydroxy-6-yl)pyridine-N -methyl-2-carboxamide 6 and a catalyst, followed by heating, etherification reaction under controlled temperature conditions to give 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl) Amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide 7.

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