99% Purity Vinblastine Sulfate Powder CAS 143-67-9

99% purity Vinblastine Sulfate powder is a chemical substance with the molecular formula: C46H60N4O13S, molecular weight: 909.06, melting point: 267 C (Dec.) (Lit.). It is white or off-white crystalline powder, odorless, hygroscopic, yellow when exposed to light or heat, and easily soluble in water.

It is an alkaloid from Catharanthus roseus, a plant of Apocynaceae. It is a cell cycle-specific anti-tumor drug, which acts on the G1, S, and M phases, and has a delaying effect on the M phase. It can interfere with the formation of proliferating cell spindles and stop mitosis in the metaphase. At a higher dose, it can directly destroy chromosomes, crystallize microtubule protein and prevent the assembly of microtubule protein. In addition, it has an immunosuppressive effect.

What is Vinblastine Sulfate?

Vinblastine antitumor drugs are alkaloids extracted from Catharanthus roseus, a plant of Apocynaceae, and originated in South Asia, East Africa, tropical America, and Hainan, China. The whole herb of Catharanthus roseus can relieve pain, diminish inflammation, sleep, relax bowels and induce diuresis. The whole plant is toxic, and it will cause symptoms such as leukopenia, thrombocytopenia, muscle weakness, paralysis of limbs, etc. Catharanthus roseus contains dozens of indole alkaloids, among which 99% purity Vinblastine Sulfate powder is one of them, which has an anti-cancer effect and is widely used in clinics as an anti-tumor drug with high medicinal value. At present, there are four kinds of vinblastine, vincristine, vindesine, and vinorelbine that have been listed and used clinically.

Studies have shown that the cytotoxicity of vinblastine drugs is realized by binding with tubulin. They have a common binding site on tubulin dimer, which can inhibit the polymerization of microtubules, hinder the formation of pituitary microtubules, and thus stop the metaphase of mitosis, thus preventing cancer cells from dividing and proliferating.

What are the uses of Vinblastine Sulfate?

1. 99% Purity Vinblastine Sulfate Powder is used for malignant lymphoma.

2. It is used to treat Hodgkin's disease and choriocarcinoma, and also has a certain curative effect on lymphosarcoma, acute leukemia, and breast cancer.

3. It is a natural alkaloid isolated from Catharanthus roseus, which binds to tubulin and inhibits the formation of microtubules, leading to the division of mitotic spindle and the arrest of tumor cells in the M phase of the cell cycle.

What precautions should be taken during the use of Vinblastine sulfate?

① It can cause bone marrow suppression, mainly manifested as leukopenia. The white blood cell count can reach the lowest point 8 ~ 10 days after taking the medicine, and it can be recovered after 2 ~ 3 weeks after stopping taking the medicine. Thrombocytopenia can also be seen, so we should check the hemogram regularly.

② Nerve damage is lighter than vincristine sulfate, and peripheral nerve symptoms can be seen.

③ A few patients may have headaches and depression. Gastrointestinal reactions may include loss of appetite, nausea, abdominal pain, diarrhea, stomatitis, and digestive tract ulcer. There may also be alopecia, orthostatic hypotension, etc.

④ Because of its strong irritation, the injection site may have pain and thrombophlebitis.

⑤ Because it is mainly excreted by the liver and gallbladder, the toxicity of patients with biliary obstruction and poor liver function increases.

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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.

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