Carboplatin 99% White Powder CAS 41575-94-4

Carboplatin 99% White Powder is easy to dissolve, does not need hydration diuresis, and is easy to use. However, bone marrow suppression is severe, and a few patients may have abnormal liver function. The scope of action of Carboplatin is generally similar to that of cisplatin. The main advantage of this new analog is its different toxicity. At present, carboplatin is used as a palliative treatment for recurrent ovarian cancer, including among patients who have previously used cisplatin. Clinical studies have also pointed out that PARAPLATIN can produce objective responses to head and neck tumors, small cell lung cancer, and testicular seminoma

What's the difference between the mechanism of action of this product and cisplatin?

The action mechanism of carboplatin is mainly to cause cross-linking between and within DNA strands, interfere with DNA molecules and inhibit cell DNA synthesis. Like cisplatin, scientists believe that the result of DNA damage is damage to DNA replication and transcriptional properties, which is likely to be the killing mechanism of this drug. However, this product mainly acts on the N-7 and O-6 atoms of guanine in DNA to produce cytotoxicity. Since the cyclobutane ring in the Carboplatin 99% white powder molecule is more stable as a ligand than the chloride ion group in cisplatin, it was initially thought that PARAPLATIN may not have ototoxicity, nephrotoxicity, and neurotoxicity as cisplatin. However, through systematic biological evaluation and a large number of clinical trials, it has been proved that the nephrotoxicity, bone marrow inhibition, ototoxicity, and neurotoxicity of Carboplatin 99% White Powder are not as serious as cisplatin, However, the damage to the body can not be ignored. There is cross-resistance between the antitumor effect of PARAPLATIN in vivo and cisplatin, so the tumor cells insensitive to cisplatin are also resistant to carboplatin. In the study of mice, it was found that carboplatin not only inhibited the growth of tumors but also had a certain radiosensitization effect.

What is the user's clinical evaluation?

The effective rate of advanced ovarian cancer was 65%, the effective rate of small cell lung cancer was 41%, and the effective rate of bladder cancer and newly diagnosed ovarian cancer was 51%. The remission rate of squamous cell carcinoma of the head and neck was 27%. This product can be used in patients who cannot tolerate cisplatin due to renal function injury, intractable vomiting, hearing loss, or neurotoxicity. It has no cross-resistance with other chemotherapeutic drugs. It can be used alone or in combination with other chemical drugs and can be combined with surgery and radiotherapy to improve the curative effect.

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