Raw Powder Sunitinib Malate CAS 341031-54-7

Raw Powder Sunitinib Malate is white powder with molecular formula: C26H33FN4O7, molecular weight: 532.57, melting point: 189-191°C, soluble in water (> 25 mg/ml, pH 1.2-6.8), DMSO(>10 mg/ml) and methanol. It is a new type of multi-target tyrosine kinase inhibitor with dual functions of anti-tumor and anti-angiogenesis. Its metabolism depends on the cytochrome P450 enzyme, and it is an inhibitor of vascular endothelial growth factor receptor, platelet-derived growth factor receptor, stem cell factor receptor, and tyrosine kinase. It is suitable for gastrointestinal stromal tumors that are resistant to imatinib or progress after treatment, or for the treatment of renal cell carcinoma.

What is Sunitinib Malate?

Raw Powder Sunitinib Malate is the first drug in a new class of drugs that can selectively target a variety of receptor tyrosine kinases. The primary development goal of Sunitinib Malate is to treat gastrointestinal stromal tumors and metastatic renal cell carcinoma which are unresponsive or intolerant to standard therapy. Sunitinib Malate can selectively target the receptors of some proteins, which are thought to play a molecular switch-like role in tumor growth.

Among them, inhibition of receptor tyrosine kinase is considered to "starve" the tumor by blocking the supply of blood and nutrients needed for tumor growth and has the activity of killing tumor cells at the same time, that is, Sunitinib Malate combines two mechanisms of anti-angiogenesis by stopping the blood supply to tumor cells and anti-tumor by directly attacking tumor cells.

How does Sunitinib Malate work?

Raw Powder Sunitinib Malate, a multi-target tyrosine kinase inhibitor, has dual anti-tumor effects. It is the only therapeutic drug that breaks through the 2-year survival of advanced renal cell carcinoma. It has a core position in the treatment of renal cell carcinoma and gastrointestinal stromal tumor. It was listed in the United States in February 2006. It is the first anti-cancer drug approved by the FDA of the United States to treat both diseases at the same time.

Sunitinib Malate plays a therapeutic role by preventing tumor cells from getting the blood and nutrients needed for growth.

In vivo experiments of tumor models expressing receptor tyrosine kinase targets, Sunitinib Malate can inhibit the phosphorylation process of several receptor tyrosine kinases (PDGFRβ, VEGFR2, KIT); In some animal tumor models, it can inhibit tumor growth or cause tumor regression, and/or inhibit tumor metastasis.

In which case is sunitinib malate suitable?

1. Gastrointestinal stromal tumors (GIST) that failed or could not be tolerated by imatinib mesylate.

2. inoperable advanced renal cell carcinoma (RCC).

3. Treatment of endocrine tumors such as the advanced pancreas.

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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.

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