Raw Material of Irinotecan Hydrochloride is a derivative of semi-synthetic water-soluble camptothecin, which is light yellow powder or light yellow crystalline powder at room temperature and odorless. Slightly soluble in water, ethanol, or chloroform, insoluble in acetone, molecular formula: C33H39ClN4O6, molecular weight: 623.15, melting point: 250-256°C (dec Dec.), boiling point: 257 C. Camptothecin can specifically bind to topoisomerase I, which induces reversible single-strand breaks, thus unwinding the DNA double-strand structure; Irinotecan and its active metabolite SN-38 can combine with topoisomerase I-DNA complex, thus preventing the reconnection of broken single bonds, thus resulting in cytotoxicity, which is time-dependent and specifically acts on S phase, and its toxicity is stronger than that of irinotecan.
What is Irinotecan HCL?
Raw Material of Irinotecan Hydrochloride, as a single drug, is used to treat patients with advanced colorectal cancer who have not received chemotherapy before, together with 5- fluorouracil and folinic acid, and to treat patients who have failed to receive chemotherapy with 5- fluorouracil. Irinotecan has broad-spectrum and strong anti-tumor activity in both in vivo and in vitro studies. It is important that irinotecan and its metabolites are still effective against tumors expressing multidrug resistance.
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Real shot pictures of Irinotecan HCL powder | Irinotecan HCL structure diagram |
What are the uses of irinotecan hydrochloride?
1. Raw Material of Irinotecan Hydrochloride combined with peripheral muscle relaxant can reduce muscle relaxation.
2. It is used as an anti-tumor drug.
3. It is used to prepare injections.
4. It is used as an intermediate of steroid hormone drugs.
5. It is a water-soluble topoisomerase I inhibitor.
6. Its antitumor effect is mainly due to the inhibition of DNA topoisomerase type ⅰ, which hinders the synthesis of DNA.
Who can't use irinotecan hydrochloride?
1. Patients with chronic enteritis and/or intestinal obstruction.
2. Having a history of severe allergic reaction to irinotecan hydrochloride trihydrate or its auxiliary materials.
Patient.
3. Pregnant and lactating women.
4. Patients whose bilirubin exceeds the upper limit of normal value by 1.5 times.
5. Patients with severe bone marrow failure.
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.
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