Enzalutamide pure Powder is an androgen-like receptor antagonist. At present, it can be used in the treatment of metastatic castration tolerant prostate cancer after chemotherapy (that is, such patients whose tumors or cancer cells are still growing after chemotherapy) and prolong the survival time of patients with prostate cancer. As an androgen receptor inhibitor, XTANDI powder has different targets from cabazitaxel approved in 2010, and abiraterone approved in 2011. In particular, enzalutamide can competitively inhibit the binding between androgen and receptor, inhibit the nuclear transport of androgen receptor, and the interaction between androgen receptor and DNA.
| Molecular formula |
|
|
|
Item |
Standard |
Test Results |
|
Appearance |
A white crystalline powder |
Complies |
|
Identification |
The principal peak in the chromatogram obtained with the test solution is similar in retention time to principal peak in the chromatogram obtained with the reference solution. |
Complies |
|
Impurities |
Total impurity ≤0.5% Max single impurity ≤0.1% |
0.2% 0.06% |
|
Mineral count |
≤4.0 % |
1.53% |
|
Residue on ignition |
≤3% |
0.05% |
|
Chromatographic purity |
Should Conform |
Complies |
|
Loss on drying |
≤ 3% |
0.3% |
|
Moisture |
≤ 0.3% |
0.15% |
|
Coliforms (MPN/100g) |
≤10 |
Negative |
|
Mold |
≤50 CFU/g |
Negative |
|
Salmonella |
Negative |
Complies |
|
Staphylococcus aureus |
Negative |
Complies |
|
purity |
≥98% |
98.9% |
| Conclusion： |
Conform with enterprise specification . |
What is the patient's evaluation after use?
Enzalutamide pure Powder is an androgen receptor inhibitor that can be used to reduce the progression of chemotherapy-related diseases. We know that androgen therapy has been the standard treatment of choice for patients with metastatic prostate cancer for 70 years. With the in-depth exploration of disease molecules, researchers found that androgen receptors play an important role in driving the development of prostate cancer throughout the course of the disease. At the same time, a new generation of androgen receptor antagonists, such as abiraterone and enzalutamide, have become the focus of science. Studies have proved that they can benefit patients with advanced prostate cancer after chemotherapy. Both enzalutamide and abiraterone are targeted to treat prostate cancer, with similar effects. According to relevant medical statistics, the similarity rate is as high as 96.5%, but these subtle differences determine that the price of products will be different. For example, abiraterone needs to be used together with steroids, while enzalutamide does not; Abiraterone needs to limit diet, while enzalutamide does not.
What is the pharmacological action of this product?
Enzalutamide pure Powder is an androgen receptor (AR) antagonist. Adding 16 β- [18F] fluorine-5 α- In the competitive experiment of DHT (18-FDHT), enzalutamide has a higher affinity than bicalutamide when acting on AR protein. Enzalutamide had no effect on LNCaP prostate cells. In parental LNCaP cells, enzalutamide inhibited the production of prostate-specific antigen (PSA) and transmembrane serine protease 2 (TMPRSS2) and their binding to synthetic androgen r1881. Enzalutamide can inhibit the translation activity of mutant AR protein (Trp at position 741 of w741c is mutated to Cys). Mdv310 also blocks nuclear translocation and ligand-receptor complex recruitment of coactivators. In vitro experiments showed that enzalutamide could reduce the tumor volume in the model experiment of xenotransplantation of prostate cancer in mice. The main metabolite of enzalutamide was n-Demethylenzalutamide.
What Are The Adverse Reactions To This Product?
The main side effects of this product are Hypertension and fatigue. The most common symptoms are upper respiratory tract pain, dizziness, muscle weakness, dizziness, dizziness, lower respiratory tract pain, muscle weakness, dizziness, dizziness, dizziness, dizziness, lower back pain, muscle pain, muscle weakness, and flushing syndrome (≥ 5%).
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Enzalutamide pure Powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
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