What is Topotecan Hydrochloride?
Topotecan Hydrochloride 99% powder is a water-soluble derivative of camptothecin. It is the hydrochloride form of topotecan, successfully developed by SmithKline Beecham in the United States. In 1996, it was approved by FDA to be marketed in the United States under the brand name Hycamtin, which is used as a second-line treatment for ovarian cancer (OVC). In 1999, the US Food and Drug Administration (FDA) approved topotecan hydrochloride as a treatment for small cell lung cancer (SCLC), which has been marketed in Britain, Germany, France, and dozens of other countries and regions. The drug is currently in phase iii clinical trials for the treatment of non-small cell lung cancer, cervical cancer, and myelodysplastic syndrome.
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| Topotecan Hydrochloride Picture | Topotecan Hydrochloride MF |
Topotecan Hydrochloride Benefits
Topotecan Hydrochloride 99% powder is mainly used in:
Topotecan HCL can enter the BBB and is as effective orally as intravenously. Topotecan HCL has low predictable myelosuppressive toxicity, and other non-hematologic toxicity is mild. At present, domestic manufacturers have produced, and used it for the clinical treatment of small cell lung cancer, ovarian cancer, and other tumors. Topotecan HCL inhibits the activity of topoisomerase I, an enzyme required for DNA replication. After intravenous injection, the product is hydrolyzed in blood and excreted through urine. This product has a rapid serum clearance rate of 62L per hour and is widely distributed in vivo with a half-life of about 2 ~ 3h. Preclinical tests show that the product has anti-tumor activity against all kinds of tumors. In phase, I clinical trials, the product also showed significant antitumor effects in cisplatin-resistant ovarian cancer patients.
Application of Topotecan Hydrochloride
Topotecan hydrochloride, a semi-synthetic derivative of camptothecin, is an antitumor drug that can inhibit the activity of topoisomerase I. Topoisomerase ⅰ can induce reversible breakage of DNA single-strand, loosen DNA helix, bind to topoisomerase ⅰ -DNA complex, and prevent reconnection of these single-strand broken strands. Its cytotoxic effect is in DNA synthesis.
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How To Obtain Samples of Topotecan Hydrochloride?
Welcome to send an inquiry to sunny@faithfulbio.com at any time for a free sample if you need the API powder Topotecan Hydrochloride.
The Best Topotecan Hydrochloride Manufacturer And Supplier
Faithfulbio has rich experience in exporting raw materials and has established stable and long-term cooperative relations with our customers. We always put product quality and service first. If you have raw material purchasing needs, please contact us. We can confirm the order with you according to your purchase quantity. We also support our first cooperation starting from samples. In addition, our fast and safe transportation also enables you to Eliminate the trouble of customs clearance.
We have confidence in the quality of our products, but if there are any after-sales problems, we will respond as soon as possible and solve them with you in the best way.
Why Choose Faithfulbio Topotecan Hydrochloride?
Faithfulbio specialize in Topotecan Hydrochloride for several years, we supply products at a competitive price, and our product is of the highest quality, because we are very strict in product production and testing, and have a complete and mature system. In addition, our employees The quotation for the product is very competitive.
A variety of shipping methods for you to choose
Transportation Time | Shipping method | Cargo weight requirements | Advantage |
3-7 days | DHL,Germany DHL,Germany DPD, | Suitable for under 50kg. | We have warehouses in Germany and California, the USA, |
7-15 days | By Air | Suitable for more than 50kg. | |
15-60 days | By Sea | Suitable for more than 500kg. |
kindly note: Use this compound for research purposes only. All compounds have risks. Please consult your doctor and learn about available studies before use. In addition, the above description of the compound comes from online literature. If there is any infringement, please contact us to delete it.
Where To Buy Topotecan Hydrochloride?
Just send an email to sunny@faithfulbio.com, or submit your requirement in the bottom form, we are of service at any time!
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