Pure Bortezomib Powder CAS 179324-69-7

Pure Bortezomib Powder is a new targeted drug for myeloma. Bortezomib was developed, It is known as the revolution of tumor treatment and the great progress in the treatment of multiple myeloma. Bortezomib was quickly approved by FDA in May 2003. It is the first proteasome inhibitor. and won the Nobel Prize in chemistry in 2004. In 2006, it won the highest honor Prix Galien in the pharmaceutical industry.

Why is multiple myeloma called a nightmare?

Multiple myeloma is a cancer that forms in white blood cells (called plasma cells). Healthy plasma cells help you fight infection by producing antibodies that recognize and attack microorganisms. In multiple myeloma, cancerous plasma cells accumulate in the bone marrow and crowd out healthy blood cells. Instead of producing beneficial antibodies, cancer cells produce abnormal proteins that may cause complications. Before Pure Bortezomib Powder, multiple myeloma was a nightmare for patients with this disease. Bortezomib is a breakthrough drug for myeloma, The approved indications are multiple myeloma and mantle cell lymphoma. This product passes and β Reversible binding of 5 subunits inhibited the ct-l activity of the 20S proteasome.

Why is 26S proteasome the key?

26S proteasome is a large protein complex that can degrade ubiquitin. Pan proteasome channel plays an important role in regulating the concentration of specific proteins in cells to maintain the stability of the intracellular environment. Proteolysis will affect the multi-level signal cascade in cells, and this damage to the normal intracellular environment will lead to cell death. The inhibition of the 26S proteasome can prevent the hydrolysis of specific proteins. This product is used as a proteasome inhibitor for multiple myeloma. Reversible 26S proteasome inhibitor, a barrel-shaped multi-protein particle, the efficacy of the product exists in the nucleus and cytoplasm of all eukaryotic cells.

What is the market prospect of this product?

Pure Bortezomib Powder is a therapeutic drug for malignant tumors of the hematopoietic system. Its appearance is a white or almost white crystalline powder. It is easily soluble in dimethyl sulfoxide, and ethanol and difficult to dissolve in an aqueous solution. It is a reversible inhibitor of 26S proteasome chymotrypsin-like activity in mammalian cells. 26S proteasome is a large protein complex that can degrade ubiquitin. Pan proteasome channel plays an important role in regulating the concentration of specific proteins in cells to maintain the stability of the intracellular environment. Proteolysis will affect the multi-level signal cascade in cells, and this damage to the normal intracellular environment will lead to cell death. The inhibition of the 26S proteasome can prevent the hydrolysis of specific proteins. This product is used as a proteasome inhibitor for multiple myeloma. Reversible 26S proteasome inhibitor, a barrel-shaped multi-protein particle, the efficacy of the product exists in the nucleus and cytoplasm of all eukaryotic cells.

What is the market prospect of this product?

Pure Bortezomib Powder has the following advantages: 1 It takes only about 1 month to take effect; 2. The curative effect is remarkable. Combined with drugs, the remission rate can reach more than 80%, and the complete remission rate can reach 30% ~ 40%. that the median survival time of patients treated with bortezomib combined with lenalidomide and dexamethasone (BRD) was 11 months longer than that treated with lenalidomide combined with dexamethasone (RD), and the median survival time of patients treated with BRD was 75 months; 3. High safety. It can be applied to patients with renal insufficiency or even renal failure. The curative effect is equivalent to that of patients with normal renal function, and can improve renal function; 4. Bortezomib-based induction therapy can significantly increase the amount of stem cell collection and significantly accelerate the speed of stem cell collection.

Many international clinical studies have proved that the efficacy of the regimen containing bortezomib is significantly better than the traditional chemotherapy regimen, which can significantly improve the complete remission rate, prolong the survival time and improve the quality of life. Bortezomib runs through the whole process of induction, consolidation, and maintenance of myeloma, and has become the first product to be considered in the clinic. but Bortezomib cannot be taken orally and needs frequent administration to maintain proteasome inhibition in vivo. Moreover, most tumors show inherent drug resistance, and the tumors sensitive to bortezomib eventually obtain drug resistance, which has a poor therapeutic effect on solid tumors. With the gradual establishment of the status of bortezomib as a basic drug in the treatment of myeloma, the clinical application of bortezomib has expanded rapidly. In 2016, the global sales reached US $2.5 billion and ranked among the top 10 sales of global anti-tumor brand drugs for several consecutive years. It is a truly blockbuster drug.

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