What is Toltrazuril ?
A belongs to triazinone compound, which is a new broad-spectrum special anticoccidial drug. Toltrazuril powder is white or white-like crystalline powder; Odorless. Insoluble in water.
| Product name | Toltrazuril powder |
| CAS | 69004-03-1 |
| Molecular formula | C18H14F3N3O4S |
| Molecular weight | 425.38 |
| EINECS Number | 614-893-5 |
| melting point | 194-196°C |
| density | 1.54±0.1 g/cm3(Predicted) |
| solubility | Insoluble in water. |
| Storage condition | Sealed in dry,Room Temperature |
What are the pharmacology and uses of Toltrazuril ?
(1) Pharmacodynamics
Toltrazuril powder is a triazinone compound with broad-spectrum anticoccidial activity. Widely used in chicken coccidiosis. It has a wide range of effects on coccidia, and has effects on both asexual cycles of coccidia, such as inhibiting fission of merozoites, nuclear division of microgametes and wall formation of microgametes. Because this product interferes with the nuclear division and mitochondria of coccidia, it affects the respiratory and metabolic functions of coccidia, and it can also enlarge the endoplasmic reticulum of cells and cause serious vacuolation, so it has the effect of killing coccidia.
(2) Pharmacokinetics
About 50% of toltrazuril is absorbed by poultry. After absorption, Toltrazuril mainly collects in liver and kidney, but it is quickly metabolized into sulfones. The half-life of the drug in chicks is about 2 days.
1) Toltrazuril powder is mainly used for poultry coccidiosis. This product is effective for chickens, Brucella, giant, tender, toxic and gentle Eimeria; Eimeria turkeys: Eimeria turkeys; As well as Eimeria anserina and Eimeria truncatum, have good killing and inhibiting effects. It not only effectively prevents coccidiosis and makes coccidiosis cysts disappear completely, but also does not affect the growth and development of chicks and the generation of coccidiosis immunity.
(2) The experiment proved it can effectively prevent and control lamb coccidiosis.
(3) Studies have shown that Toltrazuril is also very effective against rabbit liver coccidia and intestinal coccidia.
Toltrazuril also has the effects of resisting bacterial infection, fungal infection, antigenic insect infection, antivirus, diuresis and so on.
1. Resist bacterial infection
,It works by inhibiting bacterial protein synthesis or cell wall synthesis.
2. Antifungal infection, Toltrazuril interferes with the structural integrity and function of fungal cell membrane, thus affecting its growth and reproduction.
3. Antigen worm infection Toltrazuril powder can effectively kill or inhibit the growth of some protozoa.
4. Anti-virus, It can interfere with the replication process of viral nucleic acid and prevent it from spreading in host cells.
5. diuresis, Tortuzu has an effect by promoting the kidney to excrete excess water.
Product Specification
| Item | Specifications | Result |
| Appearance | White to off-white powder | complies |
| Identification |
IR spectrum is consistent with CRS |
Conforms |
|
The retention time of the main peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the standard preparation. As obtained in the Assay. |
Conforms | |
| Assay | ≥98% | 99.2% |
| Loss on Drying | ≤0.5% | 0.12% |
| Florides | ≥12% | Conforms |
| Related substance | Individual impurity≤0.5% | 0.25% |
| Total impurities≤1.0% | 0.63% | |
| Residue on ignition | ≤0.1% | 0.06% |
| Heavy metals | ≤5ppm | Conforms |
| Conclusion: The test results are conformed to the in-house specification | ||
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Attention: It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.
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