Cefuroxime Axetil Usp CAS 64544-07-6
Product Name: cefuroxime axetil usp
CAS NO.:64544-07-6
Molecular Formula:C20H22N4O10S
EINECS.NO:638-760-6
Synonym:Cefuroxine axetil;Cefuroxime 1-acetoxyethyl ester;CCI-15641;Ceftin;Ce-furax;Cepazine
Elobact Oraxim j Zinat;Zinnat
Certificate:FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time:1-3 days
Shipping:DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea etc
Store & Shelf life:Cool & dry place;36 months
Other:There are warehouses in the United States, Australia and Germany.
Description
what is cefuroxime axetil usp?
Cefuroxime axetil usp is a highly effective oral prodrug of the second-generation cephalosporin Cefuroxime, which is the acetoxyethyl ester of Cefuroxime. After oral administration, it is absorbed and hydrolyzed by esterases in the body to release cefuroxime, which can inhibit bacterial cell wall synthesis and prevent bacterial growth and reproduction; Therefore, it has a strong antibacterial effect and is suitable for adult acute pharyngitis or tonsillitis, acute otitis media, maxillary sinusitis, acute exacerbation of chronic bronchitis, acute bronchitis, simple urinary tract infections, skin and soft tissue infections, uncomplicated gonococcal urethritis and cervicitis, as well as pediatric pharyngitis or tonsillitis, acute otitis media, and pustulosis caused by Streptococcus pyogenes, Staphylococcus aureus (excluding methicillin-resistant strains), and sensitive strains of Enterobacteriaceae bacteria such as Haemophilus influenzae, Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis.
 |
Product name |
cefuroxime axetil |
|
CAS |
64544-07-6 |
|
|
Molecular formula |
C20H22N4O10S | |
|
Molecular weight |
510.47 | |
| EINECS | 638-760-6 | |
|
Appearance |
White to almost white powder | |
|
Melting point |
175-180 °C | |
| Storage | -20°C | |
| Density | 1.3927 (rough estimate) |
What diseases is cefuroxime axetil usp suitable for?
This product is suitable for the treatment of infections caused by sensitive bacterial strains.
1. Respiratory infections: acute pharyngitis or tonsillitis, maxillary sinusitis, acute exacerbation of chronic bronchitis, acute bronchitis.
2. Ear, nose and throat infections: acute otitis media, acute pharyngitis, tonsillitis.
3. Urinary tract infections: simple urinary tract infections, uncomplicated gonorrheal urethritis.
4. Skin and soft tissue infections.
5. Other infections: cervicitis, pustulosis.
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what is the Mechanism of action of cefuroxime axetil usp?
cefuroxime axetil usp is a second-generation cephalosporin antibiotic. After oral absorption through the gastrointestinal tract, it rapidly hydrolyzes into cefuroxime under the action of esterase and exerts antibacterial effects. The activity against Gram positive cocci is similar or slightly inferior to that of first generation cephalosporins, but it appears quite stable against beta lactases produced by Staphylococcus and Gram negative bacilli. Except for methicillin-resistant Staphylococcus, Enterococcus, and Listeria, all other positive cocci (including anaerobic cocci) are sensitive to this product. The antibacterial activity of this product against Staphylococcus aureus is inferior to that of cefazolin. 1-2mg/L of this product can inhibit both penicillin sensitive and resistant Staphylococcus aureus. Has strong antibacterial activity against Haemophilus influenzae, and is sensitive to Escherichia coli, Proteus mirabilis, and other bacteria; Indole positive Proteobacter, Citrobacter, and Acinetobacter have poor sensitivity to this product, while most Serratia are resistant. Pseudomonas aeruginosa, Campylobacter, and Bacteroidetes fragilis are resistant to this product. The mechanism of action of this product is to inhibit the synthesis of bacterial cell walls.
Product Specification
|
Items |
Specifications |
Results |
|
Appearance |
A white or white crystalline powder |
white crystalline powder |
|
Absorption coefficient |
390-420 |
395 |
|
Identification |
HPLC/IR |
Meet the requirement |
|
Crystallinity |
Corresponding |
Meet the requirement |
|
Diastereoisomer purity |
0.48-0.55 |
0.52 |
|
Water |
≤1.5% |
0.53% |
|
Heavy Metals |
≤ 20 PPM |
＜20 PPM |
|
Sulphated Ash |
≤0.2% |
0.12% |
|
Limit of microbial |
Corresponding |
Meet the requirement |
|
E- isomer |
≤1% |
0.3% |
|
Δ 3- isomer |
≤1.5% |
0.4% |
|
Any Other Impurity |
≤0.5% |
0.2% |
|
Total Impurity |
≤3.0% |
1.5% |
|
Assay(on the anhydrous basis) |
745-875μg/mg (C16H16N4O8S) |
802μg/mg |
|
≥75% (CP2005) |
82.3% |
Conclusion：Conform with specification and qualified.
How to produce cefuroxime axetil usp?
1-acetoxy-1-bromoethane and Titanium tetrafluoride (substance ratio of 1.6:1) were reacted in 50mL DMF under the catalysis of 1.5g K2CO3 for 2.5 hours. The final product of cefuroxime axetil usp was obtained by crystallization with isopropyl ether, filtration, and drying.
How and where to buy cefuroxime axetil usp wholesale?
We have 8 years of experience in selling legal scientific research drugs and have a good reputation, making us a trustworthy partner.
We ensure the quality of our products through independent experimental testing, and every customer is our VIP.
Send your Inquiry for more information, Click email：sales1@faithfulbio.comNow.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
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Note: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.
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