Raw Material Tetracycline Hydrochloride Powder CAS 64-75-5

Raw Material Tetracycline Hydrochloride Powder is a broad-spectrum antibiotic with a bactericidal effect at high concentrations. In addition to common gram-positive bacteria, Gram-negative bacteria, and anaerobic bacteria, most Rickettsia, mycoplasma, chlamydia, atypical mycobacteria, spirochetes, actinomycetes, anthrax, Listeria monocytogenes, Clostridium, and Nocardia are sensitive to this product. The effect of this product on Gram-positive bacteria is better than that on Gram-negative bacteria, but Enterococcus and penicillin-resistant Neisseria gonorrhoeae are resistant to it. This product has good antibacterial activity against Gram-negative bacteria such as Vibrio, Brucella, Campylobacter, and Yersinia, and has no antibacterial activity against Pseudomonas Aeruginosa.

What is the pharmacology of tetracycline hydrochloride?

The main component of Raw Material Tetracycline Hydrochloride Powder is tetracycline. Its mechanism is to inhibit protein synthesis by blocking the attachment of charged mRNA and rRNA to the p-peptide chain. Tetracycline blocks the site so that there is no hydrogen bond between amino acids. Tetracycline binds to the 30s and 50s subunits of microbial ribosomes. Therefore, it can prevent the formation of peptide chains. Even after drug withdrawal, this effect is usually not inhibitory and irreversible. Although tetracycline binds to small ribosomal subunits in prokaryotes and eukaryotes, mammalian cells are less susceptible to tetracycline (the 30s and 40s, respectively). This is because bacteria actively pump tetracycline, even under the concentration gradient, while mammalian cells are not affected by the mechanism of tetracycline in the cytoplasm. This explains the relatively small ectopic effect of tetracycline on human cells. The resistance mechanism of tetracycline is very wonderful. Like us who sacrifice ourselves, bacteria usually obtain resistance to tetracycline by horizontally transferring genes encoding efflux pump or ribosomal protective protein. The efflux pump actively discharges tetracycline from cells to prevent the accumulation of tetracycline inhibitory concentration in the cytoplasm. Ribosomal protective proteins interact with ribosomes and remove tetracycline from ribosomes, allowing translation to continue.

Why is tetracycline not only rich in history but also has amazing development prospects in the future?

The use of Raw material Thiamphenicol with products that inhibit bone marrow function increases the risk of bone marrow decline

The role of anticoagulant drugs, antidiabetic drugs, or anticonvulsant drugs (such as phenytoin) is increased. The combination of thiamphenicol with phenobarbital or rifampicin increased the metabolism of thiamphenicol. At the same time, taking this product alone will also have a variety of side effects due to physical characteristics, including Headache, nausea, gas, diarrhea, sprue, tongue inflammation (glossitis), and mood changes, In addition, clinical studies have found that long-term use of thiamphenicol increases the risk of bleeding and optic neuritis. If these side effects do not improve or worsen, consult your doctor. If you have serious side effects or allergic reactions to this product, please see a doctor immediately, which is characterized by swollen lips or eyelids, itchy skin rash, or dyspnea.

Why is tetracycline not only rich in history but also has amazing development prospects in the future?

Nubian mummies studied in the 1990s were found to contain large amounts of Raw Material Tetracycline Hydrochloride Powder; People speculate that its source is brewed beer because according to ancient books, mummies need to be soaked in wine for a certain period of time. It was really discovered in 1948 by Benjamin Minge Duggar as a natural product and was prescribed that year. In 1950, Harvard University Professor RB Woodward and Pfizer's team led by Francis A. Hochstein determined the chemical structure of oxytetracycline (oxytetracycline); The patent protection for its fermentation, and production was also released for the first time that year. Pfizer believed that it should obtain the right of tetracycline patent and submitted an application in October 1952. Tetracycline is a large family of antibiotics. The first tetracycline antibiotic aureomycin was found. With the progress of scientific research, it has become the most commonly used vector. For example, tetracycline is used for transcriptional activation in genetic engineering. It has been used as an engineering control switch in the mouse chronic myeloid leukemia model. Engineers were able to develop a retrovirus that could induce a specific type of leukemia in mice and then turn on and off cancer with tetracycline. This can be used to culture cancer in mice and then stop it at a specific stage for further experiments or research. At the same time, a technology for controlling Aedes aegypti (the infection vector of yellow fever, dengue fever, Zika fever, and several other diseases) is being developed. The technology uses a genetically modified strain to be implanted into a tetracycline-modified male animal raised in the laboratory, which enables the male animal to continuously release tetracycline in the wild. And his descendants inherited this characteristic, which formed a huge source of anti-epidemic

A variety of shipping methods for you to choose

Our strengths:

Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Raw Material Tetracycline Hydrochloride Powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.

Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.

If you are interested in our products, or have critical suggestions on our articles or are not completely satisfied with the products received, please contact us by Email ：sales6@faithfulbio.com   . Our team is committed to ensuring the complete satisfaction of customers.

Hot Tags: raw material tetracycline hydrochloride powder cas 64-75-5, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China