Sulfamonomethoxine CAS 1220-83-3

High quality Sulfamonomethoxine raw materials are white or almost white crystalline powders, odorless, almost tasteless, extremely slightly soluble in water and ethanol, easily soluble in dilute acids and alkaline solutions, and gradually darken when exposed to light. In addition, ICI32525 is one of the most potent broad-spectrum sulfonamide antibiotics, with strong inhibitory effects on most Gram positive and Gram negative bacteria, and slow bacterial resistance to this product; In clinical practice, it is commonly used for infections caused by hemolytic streptococcus, pneumococcus, and meningococcal bacteria

What are the pharmacological effects of Sulfamonomethoxine?

Sulfonamide products are structurally similar to para aminobenzoic acid (PABA). We know that bacteria sensitive to sulfonamide products cannot utilize folate in the surrounding environment, but can only use para aminobenzoic acid (PABA) and dihydropteridine. Therefore, this product can compete with PABA for dihydrofolate synthase in bacterial bodies, thereby preventing PABA from being used as a raw material to synthesize folate required by bacteria and reducing the amount of tetrahydrofolate with metabolic activity. Activated tetrahydrofolate plays an important role in transmitting one carbon genes in the synthesis of purine and thymidine in living organisms. It is an essential substance for bacteria to synthesize purines, thymidine nucleotides, and deoxyribonucleic acid (DNA), ultimately achieving the effect of inhibiting bacterial growth and reproduction. Sulfamonomethoxine is a new type of sulfonamide product with the strongest antibacterial activity both in vitro and in vivo. In addition to being powerful enough to inhibit most Gram positive and Gram negative bacteria, it is extremely difficult to develop drug resistance. In addition, trimethoprim inhibits dihydrofolate reductase, preventing dihydrofolate from being reduced to tetrahydrofolate. If we combine SMM with trimethoprim, it can double block the metabolism of folate and produce a synergistic antibacterial effect.

What are the clinical application details of Sulfamonomethoxine?

Sulfamonomethoxine powder has antibacterial effects on Enterobacteriaceae, Neisseria gonorrhoeae, Neisseria meningitidis and Haemophilus influenzae, such as non-enzyme producing Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella and Shigella. In addition to inhibiting most gram-positive bacteria and gram-negative bacteria, it has a strong effect on coccidia, leucoprotozoa and Toxoplasma gondii. Clinically, Sulfamonomethoxine has good absorption, high blood concentration, low acetylation rate, and high solubility of acetylation in urine, so it is not easy to crystallize urine. However, we should pay attention to the following three points in use: ① The combination of SMM and diaminopyrimidine (antibacterial synergist) can produce synergistic effect. ② Some products containing p-aminobenzoyl groups, such as procaine and tetracaine, can generate PABA in vivo, which may reduce the function of Sulfamonomethoxine, so it is not suitable for use. ③ Combined use with some diuretics can aggravate nephrotoxicity.

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