Cefradine Powder CAS 38821-53-3

Cephradine is the first generation cephalosporin, and pure Cefradine powder is a white powder with a slight odor. Slightly soluble in water, almost insoluble in ethanol, chloroform, and ether. Its characteristic is resistance to β - lactase, which has a rapid and reliable bactericidal effect on resistant Staphylococcus aureus and other broad-spectrum antibiotic resistant bacteria.

What are the antibacterial characteristics of this product?

Pure Cephradine is a broad-spectrum antibacterial product that has bactericidal effects on most Gram positive and Gram negative bacteria. Its antibacterial characteristics are: (1) its antibacterial effect on Gram positive bacteria, including penicillin sensitive and resistant Staphylococcus aureus (excluding methicillin-resistant Staphylococcus aureus), is stronger than that of second-generation and third-generation cephalosporins; The effect on gram-negative bacteria is not as good as second-generation cephalosporins, let alone third-generation cephalosporins. (2) The β - lactase produced by gram-negative bacteria is unstable, but the stability of β - lactase produced by Staphylococcus aureus is better than that of second-generation and third-generation cephalosporins. And this product is a semi synthetic broad-spectrum cephalosporin, with a similar antibacterial spectrum and use as cefradine. Compared with Cephalexin, 98% purity Cefradine has a lower incidence of adverse reactions and is the preferred drug for inflammation treatment.

What are the adverse reactions and precautions of this product?

Cefradine powder can achieve bactericidal effects by binding to one or more penicillin binding proteins (PBPs) in bacterial cells, inhibiting cell wall synthesis during bacterial cell division. Research has found that there are two mechanisms by which this product inhibits bacterial cell wall synthesis: 1. It can cause bacteria to synthesize defective cell walls with unstable permeability; 2: It can inhibit the inhibitory factors of cell wall hydrolases required for cell division, thereby promoting bacterial cell wall disintegration. In clinical applications, we have found that the adverse reactions of Cephradine are relatively mild, with an incidence rate of about 6%. Nausea, vomiting, diarrhea, upper abdominal discomfort and other gastrointestinal reactions are common. A small number of patients may experience temporary elevation of blood urea nitrogen, as well as elevation of serum aminotransferase and serum alkaline phosphatase.

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