what is Gentamycin Sulfate powder?
Gentamycin Sulfate powder belongs to the aminoglycoside antibiotics, which are glycosides formed by aminocyclohexene polyols and amino sugars. There are five basic centers in the molecule of Gentamycin, which are alkaline compounds, and the drug is the sulfate of gentamicin. Gentamycin is a complex of component C, mainly composed of C1, C2, C1a, and C2a.
Gentamycin sulfate is a glycoside antibacterial antibiotic composed of amino sugars and ligands. It is the sulfate of Gentamycin and has a spectrum similar to kanamycin. Mainly used for systemic or local infections caused by gram-negative bacteria such as Escherichia coli, Shigella, Klebsiella pneumoniae, Proteus, Pseudomonas aeruginosa, etc. Ophthalmology is used for conjunctivitis, keratitis, and other conditions. Oral administration can be used for preparing for intestinal infections or colon surgery; It can also be used in combination with metronidazole or clindamycin to reduce the infection rate during colon surgery. Gentamycin sulfate powder has good antibacterial effects on various Gram negative bacteria and Gram positive bacteria.
 |
Product name |
Gentamycin Sulfate |
|
CAS |
1405-41-0 |
|
|
Molecular formula |
C60H127N15O26S |
|
|
Molecular weight |
1506.8 | |
| EINECS | 215-778-9 | |
|
Appearance |
White to light yellow powder | |
|
Melting point |
218-237°C | |
| PH | 4.0-5.5 (0.1g/mL in H2O) | |
| Density | 1.000 g/cm3 |
what is the use of Gentamycin Sulfate powder?
1. Gentamycin Sulfate powder Used for treating sepsis, urinary tract infections, staphylococcal infections, endocarditis, and other diseases
2 Clinically used for sepsis, respiratory tract infections, biliary tract infections, suppurative peritonitis, intracranial infections, urinary tract infections, and bacterial dysentery caused by Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Shigella, Klebsiella pneumoniae, Proteus mirabilis, and other sensitive bacteria.
3. Gentamycin binds to the 30S ribosomal subunit to cause code reading errors, blocking the transfer of peptidyl tRNA from the recipient site to the donor site. The bactericidal effect of Gentamycin on Pseudomonas aeruginosa relies on its binding to the outer membrane of the cell membrane, replacing the existing cations, causing the membrane to become unstable and forming voids on the cell surface.If you need it, pls click e-mail sales1@faithfulbio.com
what is the Mechanism of action of Gentamycin Sulfate powder?
Gentamycin Sulfate powder is an aminoglycoside drug that acts on the ribosomes in bacteria, inhibits bacterial protein synthesis, and destroys the integrity of bacterial cell membranes to exert bactericidal effects. This drug can first passively diffuse through the extracellular membrane porin, and then enter the cell through the transport system through the cell membrane, irreversibly binding to the separated ribosomal 30s subunit, leading to the destruction of the A-site, and subsequently:
(1) Preventing the correct localization of aminoacyl tRNA at position A, especially hindering the binding of methionine tRNA, thereby interfering with the assembly of functional ribosomes and inhibiting the formation of the 70s initiation complex.
(2) Inducing incorrect matching of tRNA and mRNA code triplets, causing the complete ribosome's 30s subunit to misread the genetic code, resulting in incorrect amino acid insertions into protein structures, leading to abnormal and non functional protein synthesis.
(3) Obstructing the binding of the termination factor to the A-site prevents the release of the synthesized peptide chain and hinders the complete dissociation of the ribosome at 70 seconds.
(4) Obstructing the depolymerization and assembly process of multiple ribosomes, resulting in the depletion of ribosomes in bacteria.
Product Specification
|
Items |
Specifications |
Results |
|
Appearance |
White or almost white powder, |
Complies |
|
Identification |
Tests according to monograph |
Complie |
|
PH |
3.50~5.50 |
4.8 |
|
Specific Optical rotation |
+107 O- +1210 |
+1160 |
|
Methanol,% |
≤ 1.00 |
Complies |
|
Composition,%
|
C1 25.00~50.00 |
25.50 |
|
C1a 10.00~35.00 |
28.10 |
|
|
C2a +C2 25.00~55.00 |
46.40 |
|
|
Water,% |
≤ 15.00 |
8.00 |
|
Sulphated Ash,% |
≤ 1.00 |
0.30 |
|
Sulphate,% |
32.00~35.00 |
34.40 |
|
Serility |
Complies with the test for sterility |
Complies |
|
Bacterial Endotoxins,IU/mg |
≤ 1.67 |
Complies |
|
Assay,IU/mg |
≥ 590.00 |
659.00 |
Conclusion：Conform with specification and qualified.
What are the antibacterial spectra of Gentamycin Sulfate powder?
It has strong antibacterial activity against Pseudomonas aeruginosa, Proteus (indole positive and negative), Escherichia coli, Klebsiella, Escherichia coli, Serratia, Shigella, Citrobacter, Neisseria, and Staphylococcus aureus (excluding methicillin-resistant strains).
Gentamycin Sulfate powder is ineffective against Streptococcus (including Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus faecalis, etc.), anaerobic bacteria (Bacteroidetes), Mycobacterium tuberculosis, Rickettsia, viruses, and fungi
How and where to buy Gentamycin Sulfate powder wholesale?
We have 8 years of experience in selling legal scientific research drugs and have a good reputation, making us a trustworthy partner.
We ensure the quality of our products through independent experimental testing, and every customer is our VIP.
Send your Inquiry for more information, Click email：sales1@faithfulbio.comNow.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Disclaimer: The articles on this website are mainly used for scientific research and academic exchange. Please carefully discern the authenticity of their viewpoints and content. If you discover any infringement. Please contact the administrator promptly. We are not responsible for the consequences of the information and services provided on this website.
Note: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.
Send your Inquiry for more details, Click email：sales1@faithfulbio.com Now.
Hot Tags: gentamycin sulfate powder cas 1405-41-0, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China