99% Pure Abiraterone Acetate Powder CAS 154229-18-2

99% Pure Abiraterone Acetate Powder was initially developed by the British cancer research institute and BTG, and then the global development right and listing rights were transferred to Cougar biopharmaceutical company (now a subsidiary of Johnson & Johnson). Abiraterone acetate was first approved to be listed in the United States on April 28, 2011, .in while Docetaxel cannot control disease progression, Zytigais used in combination with Prednisone to treat castration-resistant prostate cancer (CRPC)

Is abiraterone acetate a targeted drug?

Abiraterone acetate tablets are not targeted drugs. Tumor-targeted drugs are those that can take advantage of the biological differences between tumor cells and normal cells to block their receptors to inhibit angiogenesis and block signal transduction pathways. They act on specific targets of tumor cells, specifically inhibit tumor cell growth and promote tumor cell apoptosis.

Currently, tumor-targeting drugs mainly include macromolecular monoclonal antibodies, such as trastuzumab and bevacizumab, and the other small molecule kinase inhibitors, such as imatinib and gefitinib. Abiraterone acetate powder is an inhibitor of androgen biosynthesis. It blocks the synthesis of androgens in the testis, adrenal gland, and prostate cancer tumor tissues by inhibiting 17 hydroxylases and c17-c20 lyase, namely CYP17.

According to the classification of anti-tumor drugs, This product belongs to endocrine therapy drugs. It can be used in combination with prednisone or prednisolone to treat metastatic castration-resistant prostate cancer and newly diagnosed high-risk metastatic endocrine therapy-sensitive prostate cancer. In castration-resistant prostate cancer, the expression of CYP17 is 17 times higher than that of primary prostate cancer, but CYP17 is not a specific change of tumor cells, so 99% Pure Abiraterone Acetate Powder is not a targeted drug.

Can abiraterone acetate treat bladder cancer?

99% Pure Abiraterone Acetate Powder is a new drug for reducing testosterone and treating advanced prostate cancer. There is no indication for treating bladder cancer in the drug book. At present, studies in the scientific community show that androgens and androgen receptors also play a part in the occurrence and development of bladder cancer. However, no institution has approved this product for the treatment of bladder cancer, so abiraterone can not be used for the treatment of bladder cancer.

The main mechanism of abiraterone acetate is to inhibit the production of key enzymes of human testosterone, especially the prostate cancer cells, which produce androgens through the autocrine pathway. It can make the patient's testosterone become 0 during clinical testing, that is, the level that cannot be detected in the laboratory. Abiraterone is widely used in the treatment of castration-resistant prostate cancer because it can reduce the level of testosterone to keep the tumor shrinking.

Which is better than Bicalutamide or this product?

Because each patient's disease stage and personal constitution are different, the treatment effect of the same drug on different patients is different, so it is impossible to determine which is better than Bicalutamide or Abiraterone Acetate.

Bicalutamide is a non-steroidal androgen antagonist, which competes with androgens for androgen receptors, prevents the uptake of androgens by cells, and the binding of androgens to target organs. It can be used to inhibit the treatment of advanced prostate cancer in combination with luteinizing hormone-releasing hormone analogs or surgical orchiectomy. The therapeutic effects of bicalutamide and abiraterone are very significant. Clinically, bicalutamide is suitable for patients with primary prostate cancer, while abiraterone is suitable for patients with prostate cancer in one process. In addition, receiving bicalutamide treatment may lead to changes in liver function. Therefore, liver function tests should be conducted regularly during the treatment of this drug. Bicalutamide treatment should be discontinued if severe changes occur.

Patients should choose drugs under the guidance of professional doctors, not by themselves.

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