Levonorgestrel Usp CAS 797-63-7

Levonorgestrel USP is a quick acting, short-term contraceptive product that significantly inhibits ovulation and prevents implantation of the fertilized egg. It also increases the thickness of cervical mucus and resistance to sperm penetration, thereby exerting a quick acting contraceptive effect. High purity Levonorgestrel powder is an organic compound that appears as a white or off white crystalline powder, odorless, and insoluble in water.This product can only be used for emergency contraception in women, which refers to post coital contraception in cases where unprotected intercourse or other contraceptive methods fail (such as condom slippage or rupture, out of control ejaculation, miscalculation of safe period, etc.). Cannot be used as a long-term contraceptive product.

What is the mechanism of action of Levonorgestrel USP?

The mechanism of action of Levonorgestrel and Norgestrel is the same. Studies have shown that Low price Levonorgestrel mainly acts on the hypothalamus and pituitary gland, causing a significant decrease or disappearance of the peak levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) during the mid menstrual period, resulting in non ovulation of the ovaries. It shows strong progesterone activity in the transformation of the endometrium, which can thin the endometrium, make the epithelial cells of the endometrium appear low columnar, and have poor secretion function, which is not conducive to the implantation of fertilized eggs. It can also make cervical mucus thick and hinder sperm penetration. In addition, Levonorgestrel USP powder also has certain androgenic activity and protein assimilation effects, and because this product is the optically active part of racemic Norgestrel, its activity is twice as strong as norgestrel, so the dosage can be reduced by half.

Will the contraceptive failure of Levonorgestrel USP pregnancy affect the physical health of the fetus?

As the most commonly used emergency contraceptive product, it should be noted that the success rate of Levonorgestrel USP contraception is not 100%. This means that even if Levonorgestrel USP is used within 72 hours after sexual intercourse, there is still a certain chance of pregnancy. At this time, the pregnant baby will not be affected by the use of Levonorgestrel, and there is no need to fear conceiving a defective baby due to the use of Levonorgestrel. According to the latest research and clinical statistical data, there is currently no evidence to prove that the failure of levonorgestrel contraception will have adverse effects on the fetus. Moreover, according to the "all or nothing" theory in early pregnancy (within 28 days after the last menstrual period), the effect of drugs on early pregnancy is either to cause miscarriage or to conceive a normal healthy baby. Therefore, there is no necessary connection between the use of levonorgestrel and the normal pregnancy process, and even because sperm can pass through the cervical environment with greater resistance, it indicates that sperm are very strong and healthy, and the resulting baby may be healthier than those obtained through conventional methods.

What are the side effects of Levonorgestrel USP?

Levonorgestrel is a high-dose progestogen that, like all progestogen drugs, has a similar effect to progesterone. Its main function is to reduce ovulation and close the cervix to achieve the effect of blocking sperm. The common adverse reactions of levonorgestrel are often manifested as menstrual changes, mostly manifested as early or delayed menstruation in the month of use, and may cause abnormal uterine bleeding. Therefore, levonorgestrel should not be used as a routine contraceptive method, and it is recommended to take it no more than twice a year. In addition, it should be noted that Levonorgestrel USP is prohibited for patients with breast cancer, reproductive organ cancer, abnormal liver function or recent history of liver disease or jaundice, venous thrombosis, cerebrovascular accident, hypertension, cardiovascular disease, diabetes, hyperlipidemia, mental depression and women over 40 years old. In addition to menstrual changes, common side effects of this product include nausea, breast tenderness, and headache. When used as emergency contraception during pregnancy, this medication does not terminate the pregnancy process and there is no evidence of harm to the fetus. The use during breastfeeding is currently shown to be safe, but it should be noted that this product does not change the risk of infectious diseases. And according to the latest research, vitamin C poder has the effects of improving immunity, anti atherosclerosis, anti-tumor, anti-aging, liver protection and detoxification, improving liver function, anti-aging, etc., but there is no direct evidence that vitamin C can reduce the adverse reactions of levonorgestrel, and the two will not have drug interactions.

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