Abiraterone Powder CAS 154229-19-3
Product Name:Abiraterone
Synonym:Cb 7598;Cb-7598;Unii-G819A456D0;17-(3-Pyridyl)androsta-5,16-dien-3beta-ol;CB-7598;CB7598;CB 7598
CAS NO.:154229-19-3
EINECS NO.:810-941-6
Molecular Formula:C24H31NO
Purity & Grade: 99%; Medicine grade
Character:White Powder
Free sample:Available
Stock:In stock
Warehouse: USA/EU/AU Warehouse
MOQ & Package: 100g; Package according to demand
Shipping: Safe and fast delivery
Lead Time: 7-15 days
Store & Shelf life: Cool & dry place; 24 months
Description
Product description
Abiraterone powder is a drug for treating prostate cancer. It inhibits the growth and spread of cancer cells by reducing the level of testosterone in the body. Abiraterone is a type of androgen biosynthesis inhibitor. Androgens such as testosterone can promote the growth of prostate cancer cells. Abiraterone reduces testosterone production by inhibiting an enzyme called CYP17A1, which is a key enzyme in testosterone synthesis. In this way, Abiraterone can slow down or prevent the growth and spread of prostate cancer cells. Abiraterone is usually used in combination with prednisone or prednisolone to treat prostate cancer that has spread to other parts of the body, especially when other treatments are no longer effective.
Abiraterone binds to wild-type and mutant androgen receptors (AR). In vitro, Abiraterone inhibits the proliferation and gene expression of androgen receptor-regulated androgen receptor-positive prostate cancer cells, and the mechanism can be explained by inhibiting steroids and anti-androgen receptors. In fact, the mutant androgen receptor activated by Eplerenone can be inhibited by higher concentrations of Abiraterone.
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COA
| Items | Standard | Result |
| Appearance | White or almost whte crystalline power | White crystalline powder |
| Identification | Positive | Positive |
| Loss on drying | NMT 0.5% | 0.36% |
| Melting range | 223~229℃ | 224~226℃ |
| Other steroids | 0.80% | ≤2.0% |
| Maximum impurities | ≤1.0% | 0.30% |
| Assay | 97.0%~103.0% | 98.2% |
| Conclusion | Conform with enterprise specification | |
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Density: 1.14g/cm ³
Boiling point: 500.2±50.0 °C at 760 mmHg
Melting point: 227-228 °C
Molecular formula: C24H31NO
Molecular weight: 349.509
Flash point: 256.3±30.1 °C
Accurate mass: 349.240570
PSA 33.12000
LogP 5.70
What does the drug Abiraterone Powder do?
Abiraterone powder is used in combination with prednisone to treat a certain type of prostate cancer that has spread to other parts of the body. Abiraterone is in a class of medications called androgen biosynthesis inhibitors. It works by decreasing the amount of certain hormones in the body.
How to know if Abiraterone Powder is working?
You may have a prostate specific antigen (PSA) blood test at least every two or three months while you're using abiraterone to check how well your treatment is working.
Can Abiraterone Powder cause liver damage?
Abiraterone is a steroidal antiandrogen used to treat metastatic, castration-resistant prostate cancer. Abiraterone is associated with an appreciable rate of serum enzyme elevation during therapy and with rare but potentially severe instances of acute liver injury with jaundice.
The first-line product for prostate cancer: Abiraterone Powder has a remarkable effect
Prostate cancer is an androgen-sensitive tumor. Endocrine therapy is an important treatment method for prostate cancer and runs through the entire course of the disease. Abiraterone achieves comprehensive blocking of androgen synthesis in the body by inhibiting the activity of CYP17, a key enzyme in the androgen synthesis pathway. As a representative of new endocrine therapy drugs, Abiraterone has also made breakthrough progress in the treatment of advanced prostate cancer. Many authoritative guidelines at home and abroad recommend Abiraterone for the treatment of prostate cancer.
Abiraterone is a CYP17 inhibitor and is mainly used in clinical practice in combination with prednisone to treat patients with metastatic and refractory prostate cancer who have received docetaxel-containing chemotherapy.
1. Abiraterone significantly prolongs the survival time of mHSPC patients and delays the disease progression. Clinical studies have confirmed that Abiraterone for the treatment of high-risk metastatic endocrine therapy-sensitive prostate cancer (mHSPC) significantly prolongs the survival time and the time without imaging progression of patients. This first-line treatment option is an important starting point for high-risk mHSPC to achieve long-term survival benefits.
2. The earlier Abiraterone is applied to mCRPC patients, the greater the clinical benefits they can obtain. For early-stage metastatic castration-resistant prostate cancer (mCRPC) with low invasiveness and no chemotherapy received, first-line treatment based on Abiraterone has benefits in prolonging overall survival, delaying disease progression, and treatment duration.
3. Abiraterone significantly improves the quality of life of patients. The patient-reported clinical outcome (PRO) results confirmed that Abiraterone treatment can significantly delay the progression of pain and fatigue, prolong or maintain the time until the quality of life declines, continuously improve overall health, and delay the occurrence of symptomatic bone-related events and the application of chemotherapeutic drugs.
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why choose us
Our Factory
Package
Shipping Methods
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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