17 Hydroxyprogesterone Acetate CAS 302-23-8
Product Name:Hydroxyprogesterone acetate
CAS.NO:302-23-8
molecular formula：C23H32O4
EINECS.NO:206-119-6
Synonym:Hydroxyprogesterone acetate;Hydroxyprogesterone vinegar;17alpha-Hydroxypregn-4-ene-3,20-dione acetate;17a-Acetoxyprogesterone;17-alpha-Hydroxylprogesterone;17α-acetoxy-4-pregnene-3,20-dione;
Test Method:HPLC/UV
MOQ & Package: 10g,100g,1kg etc Sub-package
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea etc
Store & Shelf life; Cool & dry place;36 months
Other:There are warehouses in the United States, Australia and Germany.
Description
Hydroxyprogesterone acetate is a kind of progesterone, which has a significant morphological effect on the endometrium stimulated by estrogen in vivo. It is mainly used for the diagnosis of female physiological diseases and has certain application in clinical medical research. The 17 Hydroxyprogesterone Acetate raw powder synthesized by our company is a white solid powder at normal temperature and pressure, which is insoluble in water and has a wide range of applications in the fields of medicine and organic chemistry.
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Item |
Specification |
Results |
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|
Appearance |
White to beige powder |
White to beige powder | |
|
Melting point |
≥ 240℃ |
245℃ |
|
|
Solubility |
Soluble in chloroform, ethyl acetate and methanol. |
Conforms |
|
|
Identification |
1 |
UV identification |
Conforms |
|
|
2 |
IR identification |
Conforms |
|
Related substances |
≤1.0% |
0.16% |
|
|
Max unknown single impurity |
≤0.1% |
0.084% |
|
|
Impurity A |
≤0.5% |
0.026% |
|
|
Acetic acid |
≤0.5% |
N.D. |
|
|
Loss on drying |
≤0.5% |
0.05% |
|
|
Residue on ignition |
≤0.1% |
0.07% |
|
|
Heavy metal |
≤10ppm |
≤10ppm |
|
|
microorganism |
Comply with Ch.P.2005 |
Conforms |
|
|
Residual solvent |
THF≤0.072％ |
N.D. |
|
|
|
Ethyl acetate≤0.5％ |
N.D. |
|
|
|
Ethanol≤0.5％ |
0.0122%. |
|
|
|
Isopropanol≤0.5％ |
N.D. |
|
|
|
Dichloromethane≤0.06％ |
0.031% |
|
|
Assay |
≥98.5% |
99.68% |
|
| Conlcusion: |
It conforms the standard of USP 35. |
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What are the chemical properties of 17 Hydroxyprogesterone Acetate?
Research has shown that the structure of hydroxyprogesterone acetate raw powder contains multiple ketone carbonyl units, cyclic double bonds, and ester groups, and has rich chemical conversion properties. The double bond units in its structure undergo hydrogenation reaction under appropriate reduction conditions to obtain hydrogenated hydroxyprogesterone acetate derivatives. This substance can also undergo desaturation reaction by oxidizing the carbon hydrogen bond at the allyl position under the action of an oxidant to obtain conjugated diene derivatives.
As an important progestogen compound, it has significant morphological effects on the endometrium stimulated by estrogen in the body, and therefore has wide applications in the fields of medicine and organic chemistry. It plays a particularly important role in the diagnosis and treatment of female physiological diseases, for example, it can be used in clinical practice for reactive diagnosis of amenorrhea or other causes such as threatened miscarriage and habitual miscarriage. In addition, 17a-Acetoxyprogesterone is also an important organic synthesis intermediate in the pharmaceutical industry, used for the synthesis of other steroid drugs.
What are the clinical applications and mechanisms of action of 17alpha Hydroxyprogesterone acetate?
Hydroxyprogesterone acetate raw material is mainly used to treat two types of congenital adrenal hyperplasia in clinic:
1.21-hydroxylase deficiency: This is the most common type, affecting about 95% of CAH patients. It leads to a decrease in the production of cortisol and aldosterone, while increasing the production of androgen.
2.11-β-hydroxylase deficiency: This type is rare and mainly affects the regulation of androgen.
Its mechanism of action is to inhibit the excessive production of androgen in adrenal gland. Hydroxyprogesterone acetate can help control the level of androgen in patients and reduce the abnormal sexual development and other symptoms caused by excessive androgen.
How to use Hydroxyprogesterone acetate correctly?
The treatment of 17alpha-Acetoxyprogesterone usually requires long-term use to maintain a stable hormone level. Therefore, the personalized plan is the best choice. Under normal circumstances, the doctor will adjust the dose according to the specific situation of the patient. Patients should also follow the doctor's advice and have regular blood tests to monitor the hormone level and ensure the drug effect.
What are the risks and side effects of Hydroxyprogesterone acetate?
Although 17-alpha-Hydroxylprogesterone is very effective in the treatment of CAH, long-term use may be accompanied by some side effects, including but not limited to:
Abnormal liver function: Although rare, liver function should be checked regularly.
Effects of growth and development: Special attention should be paid when using in children, which may affect growth and development.
Changes in other hormone levels: It may affect the balance of other hormones and need to be monitored by a doctor.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide 17 Hydroxyprogesterone Acetate powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
FAQ:
Q1: What chemicals does your company mainly deal in?
Answer:Our company specializes in the business of organic solvents, inorganic acids and bases, special polymer materials, pharmaceutical intermediates, electronic chemicals, water treatment chemicals, etc. We offer a variety of specifications and purities of products to meet the needs of different industrial fields. For detailed product information, please refer to our product catalog page.
Q2: Can you provide customized or specific specifications of chemicals?
Answer: Sure. We have a professional technical team that can provide customized products, specific purity, special packaging, and other services according to the specific needs of our customers. Please contact us through business cooperation channels to discuss your needs in detail.
Q3: How to obtain the Technical Data Sheet (TDS) and Safety Data Sheet (SDS/MSDS) of the product?
Answer: All product technical manuals (TDS) and safety data sheets (SDS/MSDS) can be downloaded from our official website's product details page. If you need help or cannot find the required documents, please contact your sales representative or customer service directly, and we will provide them to you immediately.
Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.
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