Progesterone Powder CAS 57-83-0

Progesterone powder, abbreviated as P4, also known as progestin, is an endogenous steroid and progesterone hormone, and the main progestin in the body, secreted by the ovaries of women. Before ovulation, the daily production of progesterone is 2-3mg

 

Product name	Progesterone
CAS.NO:	57-83-0
Density:	1.1±0.1 g/cm3
Boiling point:	447.2±45.0 °C at 760 mmHg
Melting point:	128-132 C (Lit.)
Molecular formula:	C21H30O2
Molecular weight:	314.462
Flash Point:	166.7±25.7 °C
Accuracy:	314.224579
PSA：	34.14000
LogP：	4.04
Vapor pressure:	0.0±1.1 mmHg at 25°C
Refractive index:	1.542
Storage conditions:	It should be sealed in a cool and dry place and kept away from light.

 

What is the function of Progesterone?

Progesterone powder is a hormone secreted by the corpus luteum in the first trimester. On the one hand, it can make women's uterine smooth muscle relax and reduce excitability, thus facilitating the implantation of fertilized eggs; on the other hand, it can inhibit uterine contraction and "rejection" reaction, and play the role of "preventing miscarriage".The detailed explanation of its function is as follows:

1. Progesterone has significant morphological effects on estrogen-stimulated endometrium in vivo, which is necessary to maintain pregnancy. In the late menstrual period, together with estrogen, it can promote the development and proliferation of the endometrium, and make it change from proliferation stage to secretion stage, creating conditions for implantation of fertilized eggs and embryo development;

2. It causes the endometrium to fall off entirely during menstruation;

3. It inhibits uterine movement and the sensitivity to oxytocin during pregnancy, has the effect of preventing miscarriage, and together with estrogen, promotes the further development of the mammary gland and prepares for milk production;

4. High dose of Progesterone can inhibit the secretion of luteinizing hormone by the anterior pituitary through the feedback regulation of the hypothalamus-anterior pituitary-ovarian axis, thus inhibiting ovulation and playing a contraceptive role.

Real shot pictures of Progesterone raw powder	Progesterone structure diagram

 

What is the physiological function of progesterone?

1. Progesterone maintains the pregnancy of female animals and leads to a series of physiological changes in pregnant animals, such as inhibition of estrus of female animals.

2. Promote the thickening of uterine mucosa, the curvature of glands, and the increase of secretion function.

3. Restrain the peristalsis of the uterus, shrink the cervix, secrete viscous liquid, etc. These physiological changes provide suitable environmental conditions for the operation, growth, and development of early embryos, implantation, and the continued growth of the fetus after implantation.

4. A small amount of progesterone cooperates with estrogen to promote estrus in female animals. The cooperation of progesterone and prolactin can promote the development of mammary glands.

5. Progesterone participates in the feedback regulation of the hypothalamus and anterior pituitary, which makes the secretion of animal reproductive hormones coordinated and balanced.

 

What effect does progesterone in human body have?

1. In the late stage of the menstrual cycle, glandular growth occurs in the uterine mucosa, causing congestion and thickening of the endometrium, preparing for the implantation of fertilized eggs. After implantation of the fertilized egg, it produces a placenta and reduces the excitability of the pregnant uterus, inhibiting its activity and ensuring safe fetal growth.
2. Under the combined action of estrogen, it promotes the full development of breasts and prepares them for lactation.
3. Close the cervix, reduce mucus and thicken it, making it difficult for sperm to penetrate; At high doses, the negative feedback effect on the hypothalamus inhibits the secretion of pituitary gonadotropins, resulting in ovulation inhibition.
4. Competitive antagonism against aldosterone promotes the excretion of sodium and chloride ions and diuresis.
5. Has a mild warming effect, causing a higher basal body temperature in the luteal phase of the menstrual cycle.

 

What effect does progesterone have in the early pregnancy?

1. Progesterone inhibits uterine contraction.

Some people think that progesterone can change the ion permeability of uterine muscle cell membrane, make the membrane in hyperpolarization state, thus reducing the excitability of uterine muscle, and at the same time reducing the sensitivity of uterine muscle to various stimuli (especially oxytocin). Therefore, the pregnant uterus will not contract violently and progressively, the embryo will not be affected, and the pregnancy will be maintained. Accordingly, progesterone is commonly used in clinic to protect the fetus.

Some people hold the opposite opinion, thinking that although the experiment proves that progesterone inhibits the excitement of uterine muscles, it is an in vitro condition, and the dose used in the experiment far exceeds the physiological concentration. In addition, in the treatment of threatened abortion, it was found that the effect of progesterone was equivalent to that of placebo by double-blind method.

 

2. progesterone maintains demoulding reaction.

Decidual cells are transformed from endometrial stromal cells and contain glycogen granules that provide nutrients to the blastocyst. The use of "rabbit anti mouse decidua serum" on pregnant mice can cause miscarriage, indicating the importance of decidua in maintaining pregnancy. Removing the bilateral ovaries of animals with pseudopregnancy induced decidua reaction can lead to decidua necrosis and liquefaction; If exogenous progesterone is administered, it can prevent decidual degeneration. Progesterone is essential for maintaining the decidual response.

 

3. Progesterone inhibits immune response.

Pregnant eggs are a kind of "Semiallograft", but why are they not immune rejected by the mother when they are implanted? It was found that some tumor cells were transplanted into the uterine cavity of animals, and only in animals injected with progesterone, the tumor cells were not rejected and implanted into the uterine wall, indicating that progesterone could inhibit the immune response. Similarly, it can be explained that during normal pregnancy, the increase of progesterone can prevent the embryo from being rejected by the mother and maintain pregnancy. If progesterone is insufficient, the embryo, like a foreign body, is rejected by the mother and aborts.

 

What are the precautions for Progesterone?

1.The following groups of people should use it with caution：

(1) It should be used with caution within 4 months of pregnancy and should not be used as an early pregnancy test.

(2) Those with a history of depression should use it with caution.

(3) Patients with edema should use it with caution.

 

2. Long-term medication should pay attention to checking liver function, especially breast examination.

 

3. At present, natural progesterone is commonly used to treat threatened abortion and habitual abortion. Synthetic progesterone has a teratogenic effect on fetuses, so it must be used with caution.

 

4. Whether there is progesterone deficiency in premenstrual syndrome is inconclusive, so the use of progesterone for treatment is still controversial, but it is still used clinically at present.

 

5. Once jaundice occurs, the drug should be stopped.

 

Our advantages

Our company has passed the certification of the US Food and Drug Administration and ISO19001 quality management system. And, we have signed internal cooperation agreements with multiple factories and laboratories in China, so our company can provide you with very good Progesterone Powder prices. If you are interested, please email us at:allen@faithfulbio.com

 

A variety of shipping methods for you to choose

Transportation Time	Shipping method	Cargo weight requirements	Advantage
3-7 days	DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS	Suitable for under 50kg. International door to door express	We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places.
7-15 days	By Air	Suitable for more than 50kg. fast and cheaper for large order
15-60 days	By Sea	Suitable for more than 500kg. Cheapest shipping way

 

 

 

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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.

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