Original Powder Abiraterone CAS 154229-19-3

Original Powder Abiraterone is an inhibitor targeting cytochrome CYP17. Abiraterone acetate is hydrolyzed in vivo to produce abiraterone, which can reduce the production of testosterone by inhibiting cytochrome CYP17. It is suitable for the treatment of patients with castrated refractory anterior adenocarcinoma (CRPC) who have received previous chemotherapy containing Docetaxel. Clinical trials have shown that abiraterone combined with prednisone can significantly prolong the overall survival of patients with metastatic prostate cancer who have previously received Docetaxel chemotherapy.

How effective is abiraterone on advanced prostate cancer?

At present, Original Powder Abiraterone is more and more widely used in clinics. In the past, the traditional treatment concept believed that chemotherapy was the main treatment for patients with more body lesions and heavy metastatic load. However, in recent years, many clinical applications believe that this product can also play a better therapeutic effect for patients with high metastatic load, and in recent years, the use has gradually transitioned to the hormone-sensitive stage.

Clinical data show that it is relatively good, especially in the drugs for advanced prostate cancer. For patients with advanced castration-resistant prostate cancer who have received chemotherapy, the median survival time after using This product can reach 34 months. For patients with advanced castration-resistant prostate cancer who have not been treated with chemotherapy, the median survival time after using This product is about 42 months, and the treatment data are very considerable.

How long is abiraterone generally resistant?

Original Powder Abiraterone has the advantages of small side effects and tolerance for most patients. The average resistance time is 14 months, but this time is only the average time, not the absolute time. Therefore, the judgment of drug resistance needs to be analyzed according to the specific situation of patients. It is mainly judged according to whether the PSA (prostate-specific antigen) of the patient is elevated and in combination with the diagnosis report of imaging, their physical fitness, and the patient's condition.

1. Longer than the average drug resistance time: if the patient's condition is not very serious, the physical quality is good, the PSA value is no longer reduced, and the imaging report shows that the tumor has not progressed, it usually indicates that the treatment effect of this drug is good, and the patient can continue to use abiraterone. At this time, the time of drug resistance may be relatively long, and the time of drug resistance in some patients can reach 2-3 years, or even longer;

2. Shorter than the average time of drug resistance: if the patient's condition is relatively serious, the physical quality is poor, the PSA value is no longer reduced, but the tumor progress can still be seen on imaging, at this time, it often indicates that the drug effect is not good, and it may be that there is resistance to abiraterone, and the treatment scheme needs to be changed. At this time, the time of drug resistance may be relatively short, and drug resistance may appear within a few months.

After abiraterone resistance, patients can take enzalutamide, amphetamine, and other drugs for treatment, and can also be treated by other methods, such as genetic testing, chemotherapy, radiotherapy, and so on, which can also control the progress of the disease. In addition, for patients who take abiraterone to treat diseases, even if their condition is relatively stable and there are no uncomfortable symptoms or reactions, they should go to the hospital regularly for review so as to find out the changes in their condition as soon as possible and switch to other drugs for treatment as soon as possible.

What are the side effects of abiraterone?

Several possible side effects of abiraterone: peripheral edema, hot flashes, diarrhea, vomiting, cough, hypokalemia, hypertension, and urinary tract infection. Other important adverse reactions include heart disease, hepatotoxicity, fracture, and allergic alveolitis. Due to the pharmacodynamic effect caused by the mechanism of action, taking abiraterone may cause hypertension, hypokalemia, and fluid retention.

If you find any of the following symptoms, please stop taking the medicine immediately and consult your doctor: first, muscle weakness, muscle twitching, or violent heart beating (palpitation; beating; trembling). These symptoms may indicate that your blood potassium content is quite low.

Other side effects of abiraterone include 1. It is very common, and the incidence is higher than 10%. It is inconvenient for the legs and feet, low blood potassium, hypertension, and urinary tract infection. 2. General category, 1-10% probability of occurrence: hyperlipidemia, increased liver function test (abnormal liver function), chest pain, disordered heartbeat, abnormal heart, abnormal heartbeat rhythm. 3. Incidentally, the probability of occurrence is about 1%. Adrenal problems are related to the intake of salt and water.

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