17β Estradiol Benzoate CAS 50-50-0

What is the history of 17β estradiol benzoate?

17β estradiol benzoate was discovered in 1933 and was introduced for medical use that same year.It was the first estradiol ester to be discovered or marketed, and was one of the first estrogens to be used in medicine. Along with estradiol dipropionate, estradiol benzoate was among the most widely used esters of estradiol for many years following its introduction. However, in the 1950s, longer-acting estradiol esters that necessitated less frequent injections, such as estradiol valerate and estradiol cypionate, were developed, and have since largely superseded 17β estradiol benzoate. Nonetheless, 17β estradiol benzoate remains widely available throughout the world.

What are uses of 17β estradiol benzoate?

Product Specification

How 17β estradiol benzoate works?

17β estradiol benzoate's mechenism of action is the same as Estradiol

Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.