What is hesperetin-powder ?
Hesperetin Powder is a natural flavonoid compound found in citrus fruits. It has various biological activities, including acting as an effective broad-spectrum human UGT inhibitor, regulating apoptosis pathways, antioxidant effects, etc. It has shown retained antioxidant potential in in vitro studies and exhibits extensive inhibitory effects on human UGT. In addition, it interacts with different types of proteins, involving hydrogen bonding, π - π effects, π - cation bonding, and π - σ interactions. Hesperetin Powder also exhibits drug like properties, which may make it a potential treatment option for CHIKV infection.
| Product name | Hesperetin |
| CAS | 520-33-2 |
| Molecular formula | C16H14O6 |
| Molecular weight | 302.28 |
| EINECS Number | 208-290-2 |
| melting point | 230-232°C |
| Solubility | Soluble in DMSO (small amount), methanol (small amount) |
| Appearance | White to light yellow |
| Boiling point | 363.32°C (rough estimate) |
| Density | 1.2514 (rough estimate) |
How to extract hesperetin-powder?
Hesperetin powder is a common plant extract mainly derived from the peel of citrus fruits. The following are detailed extraction steps:
1. Raw material preparation: Firstly, fresh or dried citrus peels need to be collected as extraction materials. Ensure that the fruit peel is clean and free of impurities.
2. Extraction process: After shredding the fruit peel, Hesperetin can be extracted through methods such as hot water extraction, organic solvent extraction, or supercritical CO2 extraction. Among them, hot water extraction is one of the most commonly used methods, usually using 70-80 ℃ hot water for multiple extractions, and then combining the extraction solutions.
3. Concentration and drying: The extract is concentrated under reduced pressure to remove moisture and obtain a concentrate of Hesperetin. Afterwards, the concentrate can be further dried to form a powder.
4. Purification: In order to improve product quality, further purification of the crude extract may be necessary. This can be achieved through methods such as column chromatography and reverse phase high performance liquid chromatography (RP-HPLC) to remove impurities and improve the purity of Hesperetin.
5. Packaging and storage: The purified Hesperetin powder is packaged in aluminum foil bags or cardboard drums and stored in a cool and dry place to prevent moisture and oxidation.
It should be noted that the specific extraction conditions may vary depending on different raw materials and equipment, so appropriate adjustments may need to be made in practical operations.
Product Specification
| Items | Specification | Results |
| Assay(HPLC) | ≥98% | 98.05% |
| Appearance | Light yellow powder | Complies |
| Bulk Density | 0.60g/ml | 0.71g/ml |
| Residual Solvent | ≤0.5% | Complies |
| Pesticides | Negative | Complies |
| Heavy metals | ≤10ppm | Complies |
| As | ≤5.0ppm | 4.5ppm |
| Loss on drying | ≤5% | 3.24% |
| Odor | Characteristic | Complies |
| Particle size | 100%through 80 mesh | Complies |
| Microbioiogical | ||
| Total of bacteria | ≤1000cfu/g | Complies |
| Fungi | ≤100cfu/g | Complies |
| Salmgosella | Negative | Complies |
| Coli | Negative | Complies |
Conclusion：Conform with enterprise specification .
Where is hesperetin-powder usually used?
Hesperetin powder is a natural flavonoid compound with various biological activities and application fields. Here are some common uses of it:
1. Traditional Chinese Medicine: The traditional Chinese medicine tangerine peel contains Hesperetin and is used to treat various diseases.
2. Lowering cholesterol: It can lower plasma cholesterol levels and is beneficial for cardiovascular health.
3. Antitumor effect: Hesperetin induces apoptosis by activating the p38MAPK pathway, demonstrating potential therapeutic effects on certain types of cancer, such as colon cancer.
4. Antioxidant effect: Hesperetin powder retains its antioxidant potential in self nanoemulsion drug delivery systems, helping to clear free radicals and protect cells from oxidative stress damage.
5. Inhibit inflammation: Hesperetin is an effective and broad-spectrum human UGT inhibitor, and the UGT enzyme family is involved in the metabolism of multiple inflammatory mediators, so it may have anti-inflammatory effects.
6. Food and health products: can be used in the food and health product industry as natural pigments, antioxidants, or functional ingredients.
7. Cosmetics field: Due to its antioxidant and anti-inflammatory properties, Hesperetin powder may also be used in cosmetics to improve skin health and delay skin aging.
It should be noted that although Hesperetin powder has shown multiple potential health benefits, more scientific research and clinical trials are needed to validate its safety and efficacy before it can be applied for clinical treatment or mass production and sale.
What are the effects of hesperetin-powder ?
Hesperetin powder has multiple potential health benefits, and the following are its main effects:
1. Antioxidant and anti-inflammatory effects
Antioxidant: Hesperetin is a powerful antioxidant that can help neutralize free radicals, reduce oxidative stress, and protect cells from damage.
Anti inflammatory: Hesperetin can inhibit inflammatory reactions, alleviate inflammatory symptoms, and help alleviate inflammatory diseases such as arthritis and allergic rhinitis.
2. Cardiovascular health
Lowering cholesterol: Studies have shown that hesperetin can lower cholesterol levels in plasma, especially low-density lipoprotein (LDL) cholesterol.
Lowering blood pressure: Hesperetin has vasodilatory effects, which can help lower blood pressure and improve cardiovascular health.
3. Anti cancer potential
Inhibition of cancer cell growth: Hesperetin can inhibit the growth of a variety of cancer cells, including gastric cancer, colon cancer and breast cancer, with potential anti-cancer effects.
4. Control weight
Inhibition of obesity:Hesperetin powder can inhibit the generation of adipocytes and fat accumulation, helping to control weight and prevent obesity related diseases.
5. Improve mental health
Anti depression and anti anxiety: Studies have shown that hesperetin can improve symptoms in patients with mild depression, promote the secretion of serotonin and dopamine, and alleviate symptoms of depression and anxiety.
6. Enhance immunity
Improve vitamin C absorption: Hesperetin can increase the absorption of vitamin C, enhance immunity, and help the body resist colds and other viral infections.
7. Delaying aging
Promoting the expression of longevity genes: Research has found that hesperetin can increase the expression of CISD2 longevity genes, delay the aging process, and improve overall energy metabolism.
8. Other potential effects
Inhibition of Helicobacter pylori: Hesperetin powder can effectively inhibit the growth of Helicobacter pylori and has a blood pressure lowering effect.
9.Precautions for use
Dosage: Although hesperetin has no significant side effects when consumed in moderation, excessive intake may cause discomfort. It is recommended to use it under the guidance of a doctor or nutritionist.
Special populations: Pregnant and lactating women, as well as individuals with specific health issues, should consult a doctor before using hesperetin.
In summary, Hesperetin Powder has multiple potential health benefits, but it should be used in moderation and under the guidance of a professional.
How and where to buy hesperetin-powder wholesale?
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Note: This compound is only used for laboratory research purposes. The US authorities have not evaluated these claims. Before use, please consult your doctor and learn about available research. This product is not intended for the diagnosis, treatment, cure, or prevention of any disease.
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