4 Methylumbelliferone CAS 90-33-5

4-methylumbelliferone is a novel choleretic drug, belonging to coumarin derivatives. It is a white or off white crystalline powder at room temperature, odorless, and tasteless. Insoluble in water, slightly soluble in methanol and ethanol, easily soluble in sodium hydroxide solution, has a relaxing effect on the bile duct sphincter muscle, strong antispasmodic and analgesic effects, and can also gently and continuously promote bile secretion, strengthen gallbladder contraction and antibacterial effects. It has a significant beneficial effect on the gallbladder, is conducive to stone expulsion, and has a certain stone expulsion effect on common bile duct stones. In addition, high-purity hymecromone powder can reduce liver enzymes and restore their normal state.

How does 4 Methylumbelliferone achieve internal fragmentation?

4-Methylumbelliferone is a choleretic drug and an intermediate for the anti allergic product sodium succinate. In clinical use, It can relieve spasms of the biliary sphincter, increase bile secretion, strengthen gallbladder contraction, and inhibit bacteria. Mainly used for patients with chronic cholecystitis, gallstones, inflammation and infection of the biliary tract, and postoperative syndrome of gallbladder surgery. 7-hydroxy-4-methylcoumarin is a medication with choleretic and partial litholytic effects. It is not recommended for patients with biliary obstruction or significant liver dysfunction. During the treatment period, attention should be paid to observing whether the symptoms of the patient have improved after taking 2-3 days. If there is improvement, the patient can continue to take the medication. Active treatment can also be supplemented with antibiotics, such as cephalosporins plus hymecromone or amoxicillin plus hymecromone. Pay attention to a light diet, avoid eating overly greasy and high protein foods, and prevent the possibility of acute biliary colic in patients.

Why are there rumors that 4 Methylumbelliferone has the effect of killing mites?

In industry, 7-hydroxy-4-methylcoumarin is an important intermediate for drug synthesis, which can be used for the synthesis of many drugs.In recent years, it has been found that 7-hydroxy-4-methylcoumarin has remarkable acaricidal activity. However, 4-methylumbelliferone powder is insoluble in water, and its solubility in organic solutions such as ethanol and propylene glycol is low, so it can't reach the therapeutic dose, which limits its clinical application.

What are the other clinical uses of 4 Methylumbelliferone?

4-methylumbelliferone can also be used to treat and prevent diseases related to thrombosis, which helps to prevent blood coagulation through anticoagulation.
1. 7-hydroxy-4-methylcoumarin belongs to anticoagulant drugs, which can inhibit the activity of some protein in blood. These protein usually play an important role in the process of blood coagulation. By inhibiting these protein, the formation of thrombus can be slowed down or prevented.
2. It is often used to prevent deep vein thrombosis, which is a common thrombosis in the lower limbs, causing pain and swelling in the legs.
3. hymecromone is also used to prevent pulmonary embolism, which is a serious condition caused by thrombus falling off and blocking pulmonary artery, which can lead to dyspnea, chest pain and other symptoms.
4. For patients with atrial fibrillation, this product can also reduce the risk of stroke, because atrial fibrillation increases the possibility of thrombosis in the heart cavity, thus increasing the risk of stroke.
5. After some specific operations, such as hip replacement or knee replacement, hymecromone can effectively prevent the risk of postoperative thrombosis.
Coagulation function should be closely monitored when using 7-hydroxy-4-methylcoumarin tablets to avoid the risk of bleeding. During use, blood routine, prothrombin time and international standardized ratio should be checked regularly to ensure the safety and effectiveness of the product.

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