Product description
The agonist polypeptide Survodutide powder CAS 2805997-46-8 is an effective and selective dual agonist of glucagon receptor /GLP-1 receptor (GCGR/GLP-1R), with EC50 values of 0.52nM and 0.33nM in CHO-K1 cells, respectively. Survodutide is a 29-amino acid peptide and an effective acylated peptide containing C18 fatty acids. Survodutide achieves a powerful anti-obesity effect by increasing energy expenditure and reducing food intake.
The GLP-1 receptor agonist component reduces appetite, increases satiety and delays gastric emptying by acting on the brain. Glucagon receptor agonist components can increase energy expenditure and promote fat breakdown and reduce liver fat content by directly affecting the liver.
The most common side effects are mainly gastrointestinal diseases, such as nausea, diarrhea and vomiting, which are usually quantity-dependent. During the phase of increasing quantity, the proportion of treatment discontinuation due to adverse events was relatively high, but subsequent trials adopted a slower quantity adjustment protocol to improve tolerance.
Send your Inquiry for more details, Click email：sales4@faithfulbio.com
COA
| Test items | Specifications | Results |
| Appearance | White or almost white fluffy powder | Conform |
| Solubility | Soluble in water | Conform |
| Water Content (Karl Fischer) |
≤8.0% | 5.00% |
| Sodium ion | ≤5.0% | 1.73% |
| Acetic Acid (By HPLC) |
≤5.0% | 0.11% |
| Trifluoroacetic Acid | ≤0.5% | Not Detected |
| Peptide Purity (By HPLC) |
≥98.0% | 99.13% |
| Related Substance (By HPLC) |
Total Impurities(%)≤2.0% | 0.87% |
| Largest Single Impurity(%)≤1.0% | 0.37% | |
| Bacterial Endotoxins | ≤10 EU/mg | Conform |
| Assay | ≥90.0% | 91.39% |
| Conclusion | Conform with enterprise specification | |
Send your Inquiry for more details, Click email：sales4@faithfulbio.com
Structural differences from other dual agonists:
Survodutide is a glucagon analog, not an oxytocin analog (such as Tirzepatide):
It has higher sequence homology with natural glucagon and a stronger direct effect on the liver.
The C18 modification position differs (Tirzepatide's is near the N-terminus), affecting receptor binding mode and pharmacokinetic properties.
Metabolic dysfunction-related steatohepatitis (MASH)
Survodutide also shows great potential in the treatment of MASH (formerly known as non-alcoholic steatohepatitis or NASH). In the trial, up to 83% of the subjects achieved histological improvement in MASH without deterioration of liver fibrosis, and up to 52.3% of the subjects with stage F1, F2 and F3 fibrosis had at least one stage of improvement in their fibrosis status.
Send your Inquiry for more details, Click email：sales4@faithfulbio.com
why choose us
Our Factory
Package
Shipping Methods
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Send your Inquiry for more details, Click email：sales4@faithfulbio.com
FAQ
01. What is Survodutide powder CAS 2805997-46-8?
02. What are the benefits of Survodutide powder CAS 2805997-46-8?
Survodutide represents a promising advance in cardiometabolic medicine, with efficacy across obesity, type 2 diabetes, and MASH. It has demonstrated greater weight loss than semaglutide, significant HbA1c reductions, and histological improvements in hepatic fat and fibrosis.
03. What are the common side effects of Survodutide powder CAS 2805997-46-8?
Hot Tags: survodutide powder cas 2805997-46-8, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China