FOXO4-DRI Peptide CAS 2460055-10-9

FOXO4-DRI peptide powder is a cell permeability peptide antagonist and an aging peptide that induces apoptosis in senescent cells. Clinically, it has been found that free FOXO4-DRI raw material can competitively bind to p53, thereby blocking the interaction between FOXO4 and p53, as well as the interaction between lithium iron phosphate and p53. Furthermore, it promotes the entry of aging cells into the process of apoptosis, greatly improving the side effects of aging and chemotherapy.

What is the research on FOXO4-DRI peptide in aging?

Researchers generally believe that aging has a significant impact on male fertility. As men age, changes such as decreased hormone secretion and decreased sperm production occur in the testes,Solving this problem is considered to be an important way to treat aging.The FOXO4 is reported to be highly expressed in senescent cells. Upon activation, it binds p53 in the nucleus, preventing senescent cell apoptosis and maintaining senescent cells in situ. Leydig cells play key roles in assisting spermatogenesis. Leydig cell senescence leads to deterioration of the microenvironment of the testes and impairs spermatogenesis.In the study of sperm changes in mice, we observed that FOXO4-DRI, a specific FOXO4- p53 binding blocker, induced apoptosis in senescent Leydig cells, reduced the secretion of certain Senescence-Associated Secretory Phenotype and improved the proliferation of cocultured GC-1 SPG cells.In naturally aging mice, FOXO4-DRI peptide powder improved the testicular microenvironment and alleviated age-related hormone secretion deficiencies, thereby improving sperm quality and frequency of sperm production.

How should FOXO4-DRI peptide be diluted in cell experiments?

During FOXO4-DRI peptide transportation, powder or solution may adhere to the pipe wall or pipe cover. So, it is recommended to open
Use a centrifuge at low speed before sealing to reduce product loss.
The mother liquor prepared with ddH2O as a solvent can be directly diluted with culture medium to the desired concentration of the working solution
Degree.
The mother liquor prepared with DMSO as a solvent should ensure the final concentration of DMSO in the working solution during dilution
Try to keep it below 0.1% and not exceed 0.5% at most, and set up a corresponding concentration of DMSO control group.
It is recommended to divide the dilution process into sections to avoid rapid concentration changes that may cause compound precipitation. If during the dilution process
In the case of compound precipitation, ultrasound can be used to dissolve it again.

What is the future prospect of FOXO4-DRI peptide powder?

The current research has three main limitations. Firstly, spermatogenesis is a series of strictly regulated processes, including mitosis of spermatogonia, meiosis of spermatocytes, and spermatogenesis, during which round sperm cells transform into elongated sperm cells. The specific mechanism by which FOXO4-DRI improves sperm production function is still unclear, and it is currently difficult to make a more accurate analysis. Secondly, the dosage used in the mouse experiment was obtained based on experimental data from previous reports on this product, which may not be the optimal dosage for improving sperm production. In the future, more long-term and systematic evaluations of mice treated with FOXO4-DRI may be needed to determine specific data. Thirdly, the purpose of this experiment is to explore the crosstalk between aging Leydig cells and spermatogonia. However, simple co culture cannot effectively reflect the real environment of spermatogenesis.
In summary, although FOXO4-DRI peptide raw powder can improve spermatogenesis and sperm quality in elderly mice. And it can alleviate testicular aging phenotype. But this only provides new ideas for potential therapies to improve sperm production in elderly men. However, according to relevant blood analysis conclusions, FOXO4-DRI did not cause significant direct damage to the heart, liver, or kidneys (after 30 days of treatment in mice). However, this does not prove that the product is not potentially dangerous, and further high concentration long-term and repeated administration studies are needed. A comprehensive study is needed to determine whether FOXO4-DRI can be safely used for clinical translation.

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