Thymosin Alpha-1 Peptide CAS 62304-98-7

Thymosin Alpha-1 Peptide Powder is a Pharmaceutical peptide material used to treat chronic hepatitis B and enhance immune system responsiveness. Research has shown that it is a highly conserved acid peptide structure, mainly distributed in thymic tissue, especially thymic epithelial cells. In addition, it is also present in lymphoid tissue (such as spleen, lymph nodes) and non lymphoid tissue (such as lungs, kidneys, and brain), and its secretion and release are not regulated by other hormones or release factors. According to relevant animal studies, Thymalfasin Acetate salt can increase the expression level of interleukin-2 receptor in lymphocytes of mice activated by concanavalin A, while also increasing the secretion level of interleukin-2.

What is the pharmacological mechanism of action of Thymosin alpha 1?

Thymosin Alpha 1 Peptide is a chemically synthesized acetylated peptide composed of 28 amino acids. Studies have shown that it is the main active ingredient in the fifth component of thymus extract and belongs to the immunomodulatory class, mainly used to enhance cellular immune function. We can observe in mice that natural Thymosin alpha 1 promotes the maturation of T lymphocytes by stimulating peripheral blood lymphocyte mitogens, increasing the secretion of various lymphokines (such as interferon alpha, interferon gamma, interleukin-2, interleukin-3, etc.) produced by T cells after activation by various antigens or mitogens, and increasing the level of lymphokine receptors on the surface of T cells. It can also enhance allogeneic and autologous human mixed lymphocyte responses by activating CD4 helper cells, and may affect the recruitment of NK precursor cells.

What is the research related to Thymosin Alpha-1 Peptide in hepatitis B virus?

Thymosin Alpha-1 peptide has demonstrated clinical utility in the treatment of chronic hepatitis B virus (HBV) infection. Studies indicate that it acts on HBV-infected hepatocytes through both immunomodulatory mechanisms and direct intracellular pathways.
Using a newly established animal model under optimized experimental conditions, researchers evaluated the activity of Thymosin Alpha-1 by measuring the production of hepatitis B surface antigen (HBsAg)-neutralizing antibodies. Results showed that the chemically synthesized biological response modifier Thymalfasin powder​ restored T cell‑mediated antibody production in mice whose immune response had been suppressed by 5‑FU. Activity was observed even at a low dose of 30 μg/kg.
Further flow cytometry analysis revealed that at this dosage, Thymosin α-1 acetate promoted thymocyte replenishment and maturation. Notably, the expression of Smoothened (Smo) – a key negative regulator of proliferative responses in the Hedgehog (Hh) signaling pathway within CD4⁻CD8⁻ thymocytes – remained unaffected.

What is the current development of Thymosin Alpha-1 Peptide?

Thymosin Alpha-1 Peptide is an immunomodulatory compound that can enhance the immune response of Th1. It is precisely because it has immunomodulatory effects on immunocompromised patients that Thymosin α1 Acetate is widely used in clinical practice. Until today, scientists continue to study the clinical efficacy and mechanism of action of Thymosin α1. At present, it has been applied as an immune enhancing adjuvant in clinical treatment for tumors AIDS, It plays a significant role in congenital immunodeficiency and respiratory distress syndrome.The research on tumor is also in full swing.

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FAQ:

Q1. Is it safe to use it for a long time?
Studies have shown that long-term use (such as 6-12 months) is safe and has no obvious liver and kidney function or blood toxicity.
However, it is necessary to regularly monitor immune function indicators (such as lymphocyte subsets).

2. Can it prevent the common cold or flu?
It is not recommended as a routine preventive measure. It is only suitable for people with low immune function (such as the elderly and patients with chronic diseases) as an auxiliary prevention under the guidance of doctors.

3. Is it effective for COVID-19?
Some studies show that adjuvant therapy can reduce the inflammatory response and improve T cell failure in patients with severe COVID-19's disease. However, it is not a special antiviral raw material and cannot replace vaccines or antiviral raw materials.

4. How to save Thymosin Alpha 1?
Unopened: Store in cold storage at 2-8℃ away from light. Do not freeze.
Prepared: It is recommended to use it immediately or store it in cold storage for a short time according to the instructions.

5. Is it a hormone or an antibiotic?
It does not belong to hormones or antibiotics, has no antibacterial effect and hormone-like side effects.

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