Pinealon Powder CAS 175175-23-2

Pinealon Introduction

Xi'an Faithful BioTech Co., Ltd. is an export-oriented biotechnology and chemical trading company headquartered in Xi'an, Shaanxi Province, China. Founded in 2018, the company focuses on providing pharmaceutical intermediates, plant extracts, food additives, and feed ingredients to the global B2B market.  

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Pinealon is an artificially synthesized tripeptide, prepared by condensation of L-Glutamic acid, L-Aspartic acid and L(+)-Arginine.Its CAS number: 175175-23-2; Molecular formula: C15H26N6O8; Molecular weight: 418.4. It is not derived from natural sources. Current related research focuses on its neuroprotective effects: Pinealon Powder can inhibit the excessive accumulation of reactive oxygen species (ROS) within cells, regulate the ERK1/2 signaling pathway, thereby alleviating the negative impacts of oxidative stress, reducing cell damage, and enhancing cell survival ability.
At present, this substance is more of a research tool compound, mainly used for basic research projects to explore the mechanism of oxidative stress and the protection direction for neurodegenerative diseases.

What is the function of Pinealon?

Pinealon is a polypeptide with neuroprotective activity. Its mechanism of action is manifested in multiple aspects. It can inhibit the accumulation of reactive oxygen species (ROS) in brain cells such as cerebellar granule cells, alleviate neuronal damage caused by oxidative stress, reduce spontaneous apoptosis and necrosis of cells, and the protective effect exists in a dose-dependent manner within an appropriate concentration range. Pinealon Powder can also inhibit the over-activated ERK1/2 signaling pathway under stress conditions, delay the activation time of the pathway, and participate in cell cycle regulation. Some studies speculate that in addition to the antioxidant effect, it may also have a potential mechanism that directly acts on the cell genome. Animal experiments have found that Pinealon can enhance the activity of major cells in the brain tissue. In the acute hypoxia brain injury model of aged rats, it can promote neurogenesis and alleviate neuroinflammation. Mouse experiments also observed that it has a certain improvement trend on working memory. Other related experiments have shown that it can also protect offspring rats and reduce the harm caused by metabolic abnormalities such as high homocysteine levels in the mother during pregnancy, which interfere with neural development. It effectively improves the spatial orientation and learning ability of the offspring. All of these conclusions are based on animal experiments and have not yet formed a mature basis for human application.

What specific aspects does Pinealon's antioxidant effect cover?

First, Pinealon can directly inhibit the excessive accumulation of reactive oxygen species (ROS) in various brain nerve cells such as cerebellar granule cells and PC12 cells based on the dose relationship. Even when cells are stimulated by strong oxidants like hydrogen peroxide, the protective effect is still quite prominent. This is its main antioxidant mechanism.
Second, by eliminating harmful free radicals in the body, Pinealon can significantly reduce cell necrosis caused by oxidative stress and increase the survival probability of cells under harsh external conditions. From a molecular perspective, this protective effect is related to the time regulation of the ERK1/2 stress signaling pathway. This substance can delay the activation time of this key pathway by approximately 20 minutes, thereby cutting off the signal transmission chain that would further cause cell damage.
The antioxidant effects observed in cell experiments have also been supported in animal models. Taking the maternal hyperhomocysteinemia model as an example, Pinealon can enhance the ability of offspring neurons to resist oxidative damage and improve the cognitive performance of the animals. Additionally, a study found that Pinealon Powder already has antioxidant capabilities close to the upper limit at lower concentrations, indicating that in addition to eliminating free radicals, it may also combine other cell targets and achieve cell protection through a more complex pathway.

MF of Pinealon

CAS	175175-23-2
Molecular formula	C15H26N6O8
Molecular weight	418.4
Acidity coefficient	3.15±0.10
Density	1.63±0.1 g/cm3

Specification

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FAQ: 

Q1:What are the fundamental differences between Pinealon's antioxidant and regular vitamin-based antioxidants?
Most vitamins "passively neutralize free radicals" and are of the remedial type of antioxidants; Pinealon, on the other hand, is a pathway-regulating type of antioxidant. It not only reduces the accumulation of ROS but also corrects abnormal cell signals, reducing cellular damage at its source and belongs to a protective mechanism that regulates cell status.
Q2:Pinealon can achieve an effect saturation at a low concentration. What characteristic does this indicate?

It does not work by "accumulation of dosage", but through a high-affinity binding mechanism to target molecules. An extremely low dose can occupy the cell's action sites, which also indirectly proves that its cellular regulatory effect is specific and not simply a simple physical antioxidant.

Q3:Where does Pinealon's assistance in neurogenesis (neural regeneration) lie?

In models of hypoxia and aging damage, it can maintain the activity of neural stem cells, reduce the damage to newborn neurons caused by oxidative stress, and help the brain tissue maintain normal nerve renewal and repair capabilities.

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