Selank Peptides CAS 129954-34-3

SelankAcetate Introduction

Xi'an Faithful BioTech Co., Ltd. is an export-oriented biotechnology and chemical trading company headquartered in Xi'an, Shaanxi Province, China. Founded in 2018, the company focuses on providing pharmaceutical intermediates, plant extracts, food additives, and feed ingredients to the global B2B market.

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Selank is a nootropic, anxiolytic peptide based drug developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. Its CAS number: 129954-34-3; Molecular formula: C33H57N11O9; Molecular weight: 751.87; EINECS: 232-660-2.It is a synthetic analogue of human TUFTSIN. Selank is a heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro.The biological activity of Selank peptides powder is very active. In clinical practice, it is commonly used in health supplements and functional foods, and has the effect of improving memory and enhancing brain function.

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What is the mechanism of action of Selank Peptides?

Although many clinical studies on Selank Peptides have been conducted in rats, a study by the National Institutes of Health (NIH) in the United States has shown that Selank powder also exhibits positive therapeutic effects in humans, including improving generalized anxiety disorder, post-traumatic stress disorder, depression, and attention deficit disorder. 
According to relevant records in scientific journals, Selank is a synthetic analogue of the immunomodulatory peptide tuftsin and is closely related to Semax's products, both of which have a multi amino acid structure. Therefore, this product can also mimic the effects of various products. It has been proven that it can regulate the expression of interleukin-6 (IL-6) and affect the balance of cytokines in T helper cells. It can affect the concentration of monoamine neurotransmitters and induce serotonin metabolism. In addition, researchers have found that moderate intake of Selank powder can rapidly increase the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of rats.
In clinical trials on mice, Selank and its related peptide product Semax raw material have been found to inhibit enzymes involved in the degradation of enkephalins and other endogenous regulatory peptides, and this effect may be related to their function. In addition, it was found to affect the activity of carboxypeptidase H and carboxypeptidase inhibited by phenylmethylsulfonyl fluoride in rat nervous system tissues. It has been found that Selank produces antidepressant like effects and effects in animal models of depression and anhedonia.

What are the key points regarding the synthesis and storage of Selank Peptides?

The synthesis of peptides usually involves the condensation reaction of amino acids, which are linked into a chain structure through peptide bonds. The synthesis of Selank peptides is no exception, as it can be prepared through chemical synthesis methods such as solid-phase peptide synthesis (SPPS) or liquid-phase peptide synthesis (LPPS). These methods allow for precise control of peptide chain length, sequence, and modification. However, it should be noted that in the synthesis of Selank Peptides powder. Not only that, it needs to be carried out under appropriate temperature and pH conditions to ensure the efficiency of the reaction and the purity of the product. In addition, it is necessary to use appropriate catalysts and protective groups to control the reaction process and avoid the generation of by-products. When we obtain high-purity Selank peptides after synthesis, they need to be stored at low temperatures to maintain their stability and activity. The specific storage temperature may vary depending on the product form and purity, but it is generally recommended to store at -20 ℃ or 2-8 ℃.

What are the current application areas of Selank Peptides?

Due to its unique biological activity, Selank peptides have broad application prospects in fields such as neuroscience, psychology, and drug development. It can serve as a tool drug for studying neurological and psychiatric disorders such as anxiety and depression, as well as a candidate compound for developing new antidepressant and anti anxiety drugs.

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FAQ:

Q1:Does Selank have any effect on the blood system?
The research has found that it has antithrombotic activity. In a rat model with endothelial dysfunction, Selank can prolong the activated partial thromboplastin time (APTT) by approximately 30%, demonstrating anticoagulant and anti-platelet aggregation activities.
Q2:What biological pathways does its "anxiety relief" effect rely on?

A key mechanism is the inhibition of brain啡肽 degrading enzymes. Research has shown that the half-life of leucine-brain啡 peptide in the plasma of patients with anxiety disorders is shorter. Selank can inhibit the activity of this enzyme, thereby prolonging the action time of endogenous brain啡 peptide. This is considered to be one of the sources of its anti-anxiety effect.

Q3:Is it toxic to nerve fibers/somatic progenitor cells?

Studies based on mouse embryonic stem cell models have shown that Selank has no significant toxic effect on cell proliferation and differentiation into neuronal precursor cells at the tested concentrations. Even under certain conditions, it can increase the survival rate of cells in serum deprivation.

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