Product description
ATH-1017 CAS 2093305-05-4 is a positive regulator (agonist) of the hepatocyte growth factor (HGF)/c-Met receptor system. It is not a traditional peptide, but a small molecule. The HGF system plays a crucial role in neuronal survival, synaptic plasticity, and learning and memory.
By activating this system, Fosgonimeton aims to promote:
Neuroprotection: combating damage caused by neurotoxicity, neuroinflammation, oxidative stress, and excitotoxicity.
Neurotrophy: promoting neuronal growth, synapsis (new synapse formation), and neuronal connections.
Cognitive improvement: demonstrating effects on improving cognitive function in preclinical models, counteracting damage caused by amyloid-β (Aβ) toxicity.
Reducing Tau protein hyperphosphorylation: another key pathological feature of Alzheimer's disease.
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COA
| Items | Specifications | Results |
| Appearance | White to off-white powder | Conforms |
| Identification | HNMR Conforms to structure | Conforms |
| LC-MS | Conforms to MW | Conforms |
| Loss on drying | ≤1.0% | 0.44% |
| Residue on Ignition | ≤0.5% | 0.09% |
| Melting Point | 174.0℃-181.0℃ | 177.9℃-179.6℃ |
| Heavy Metal | <10ppm | <10ppm |
| Purity by HPLC | ≥99.0% | 99.71% |
| Conclusion | Conform with enterprise specification | |
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Molecular formula: C27H45N4O8P
Molecular weight: 584.64
Storage conditions: -20°C
The R&D status of ATH-1017 CAS 2093305-05-4
ATH-1017 CAS 2093305-05-4 is currently in the clinical trial stage
Alzheimer's disease (AD) : Multiple clinical trials have been conducted, including LIFT-AD (Phase II/III) and ACT-AD (Phase II proof-of-concept) trials. However, recent results have shown that the product failed to meet the primary or key secondary endpoints of the LIFT-AD trial. Therefore, the development for the indication of Alzheimer's disease has been halted.
Parkinson's disease dementia and Lewy body dementia: The results of the Phase II SHAPE trial show "encouraging" signs, supporting the potential therapeutic role of positive regulation of the HGF system in these diseases, but the development status of this indication is currently also shown to be suspended.
Summary
Fosgonimeton is an innovative small molecule product that aims to address the complex pathophysiology of various neurodegenerative diseases by targeting the HGF/c-Met neurotrophic system. Despite the encouraging preclinical data, the primary efficacy endpoints were not achieved in the key late-stage clinical trials for Alzheimer's disease and Lewy body dementia. Currently, its clinical development for these indications has been suspended.
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Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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FAQ
01. What exactly is ATH-1017 CAS 2093305-05-4? Is it a peptide?
02. What is the mechanism of action of ATH-1017 CAS 2093305-05-4?
Its core mechanism of action is the active modulation of the hepatocyte growth factor (HGF)/c-Met signaling system. This signaling pathway may be impaired in neurodegenerative diseases. By enhancing this system, Fosgonimeton aims to provide neuroprotection, promote neuronal health and survival, protect synaptic networks, and has anti-inflammatory effects, thereby potentially slowing the progression of neurodegenerative diseases and improving cognitive function. In preclinical models, it has been shown to counteract amyloid-β (Aβ) toxicity, reduce tau protein hyperphosphorylation, and improve cognitive impairment.
03. How safe is ATH-1017 CAS 2093305-05-4?
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