What is N-Acetyl Selank?
Xi'an Faithful BioTech Co., Ltd. is situated in Xi'an, the birthplace of the ancient Silk Road. Leveraging the city's mature logistics network and abundant fine chemical industrial resources, our enterprise has grown into an integrated fine chemical provider that delivers products to global partners. N-Acetyl Selank is an N-terminal acetylated heptapeptide derivative with the amino acid sequence Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro. It is a research-grade peptide raw material, appearing as a white powder. The N-terminal acetylation structure protects the amino terminus, reducing the efficiency of enzymatic degradation. Compared to the parent molecule Selank, it exhibits superior metabolic stability in the biological environment and an extended effective duration of action. The parent molecule Selank originated from research conducted by Russian research institutions on tuftsin immune peptides. N-Acetyl Selank further optimizes the physicochemical properties of the molecule while retaining the original core peptide backbone.
Application of N-Acetyl Selank
N-Acetyl Selank is primarily used in basic research. Due to its higher metabolic stability, it is often used to explore neuropeptide-related mechanisms. It can be used to conduct model experiments related to neural signaling pathways, neural plasticity, and changes in the body's state under stress. It is also used to study immune-related peptide mechanisms, exploring the relationship between peptide chain structure and immune-related signals. Thanks to its physicochemical properties that are suitable for nasal side experimental treatment, this substance is also used in control experiments related to peptide delivery conditions to compare the environmental tolerance performance of peptide molecules before and after modification.
COA
| Test Item | Specification | Test Result |
| HPLC Purity | ≥98.0% | 98.52% |
| Molecular Weight(MS) | Consistent with theoretical value |
Compliant |
| Amino Acid Composition | Meet theoretical amino acid ratio |
Compliant |
| Water Content(KF) | ≤5.0% | 2.15% |
| Residue on Ignition | ≤0.5% | 0.28% |
| Heavy Metals | ≤10 ppm | Compliant |
| Microbial Count | ≤100 CFU/g | Compliant |
| Appearance | White powder | Qualified |
| Solubility | Freely soluble in water | Qualified |
| Conclusion | Conform with enterprise specification | |
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N-Acetyl Selank shares a core signaling pathway with its parent Selank, both regulating the GABA-A pathway, serotonin transport, BDNF expression, the HPA axis, and immune-related signaling. The main difference lies in the physicochemical changes resulting from N-terminal acetylation: N-Acetyl Selank blocks the N-terminal amino group, resisting degradation by aminopeptidases, thus enhancing metabolic stability and allowing for a longer survival time of intact molecules in biological environments, with a higher proportion of intact molecules in mucosal environments; while Selank is more easily degraded by enzymes and has a shorter effective survival time.
Mechanism of action of N-Acetyl Selank
Regulating GABA-A-related signaling processes: Acting on GABA-A receptor-related regulatory pathways, participating in signal regulation under stress, and improving abnormal responses to stress.
Regulating the Serotonin hydrochloride transport system: Affecting the activity of Serotonin hydrochloride transport-related proteins, balancing neurotransmitter-related signal transmission, and maintaining a stable neural signaling environment.
Upregulating BDNF-related expression: Increasing BDNF expression levels, contributing to neural plasticity, and maintaining the normal physiological state of nerve cells.
Participating in HPA axis regulation: Regulating the HPA axis, buffering signal fluctuations caused by external stress, and maintaining homeostasis.
Preserving inherent immune-related activity of peptide chains: Utilizing the structure of tuftsin-derived peptides, participating in the regulation of immune-related signaling pathways, and mediating related physiological activities of immune cells.
Structural modifications bring physicochemical advantages: N-terminal acetylation modification reduces the rate of peptide molecule enzymatic degradation, improves stability in biological environments, and prolongs the effective action period of the molecule.
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Shipping Methods
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
|
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
FAQ
01. What are the main differences between N-Acetyl Selank and the parent Selank?
Both have the same core peptide chain backbone. N-Acetyl Selank has an added acetyl group at the N-terminus for protection, resulting in stronger resistance to enzymatic degradation, a longer effective duration in biological systems, and superior physicochemical stability compared to the parent Selank.
02. What are the standard storage conditions for N-Acetyl Selank?
N-Acetyl Selank should be stored sealed at -20°C for long-term storage. After reconstitution, repeated freeze-thaw cycles should be avoided to minimize molecular degradation.
03. Are N-Acetyl Selank and N-Acetyl Selank-Amidate the same substance?
No, N-Acetyl Selank-Amidate, in addition to the N-terminal acetyl group, also has an amide modification at the C-terminus. This double modification provides higher stability, making it a different derivative. Please be aware of the distinction.
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Disclaimer: All conventional products (non-customized products) pictures are taken in kind, but due to the influence of light (different time, different background light), shooting method, different display equipment parameters and other factors, there may be some differences between the picture and the real color, product color, please take the real effect prevail, product color difference is not a product quality problem.
Note: Always consult a qualified health practitioner before taking any new medication. This product is not intended to diagnose, treat, cure or prevent any disease.At the time of purchase, the international buyer agrees to assume the risk of all items arriving. We cannot replace lost or impounded items. Before sending items, you need to confirm that you agree to these terms.This is only a recommended dose based on our own experience and anecdotal evidence. We recommend that you do your own research before using this product.
Statement: This product is only used for scientific research, and the consequences of other uses are not responsible.
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