Product description
Cetrorelix Acetate powder is a synthetic decapeptide mainly used in assisted reproductive technology. For patients with controlled ovarian stimulation, it prevents premature ovulation. Cetrorelix acetate is a gonadotropin-releasing hormone (GnRH) antagonist. It can competitively bind to the receptors on the pituitary cell membrane with endogenous LHRH, thereby inhibiting the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by the pituitary gland in a dose-dependent manner.
Cetrorelix acetate is a synthetic gonadotropin-releasing hormone receptor (GnRHR) peptide antagonist with a Kd value of 0.2 nM. It can bind radioactive ligands to mouse LTK cells expressing human GnRHR.1 It inhibits the activation of hGnRHR and downstream luciferase reporter genes in mice through GnRHR agonist [D-Trp6] GnRH (IC 50 = 1.2nM) LTK- cells. In vivo, in a mouse xenograft model of human epithelial ovarian cancer, Cetrorelix acetate (60μg/ day) reduced the tumor volume to 35% of the control. The serum luteinizing hormone level was reduced by 50%. The injury induced by the 2-center Swiss (0.5mg/kg) protecting primordial follicle PMF and cyclophosphamide (Item No. 13849) had a PMF survival rate of 65% to 86%, while that of the saline control group was 46% PMF survival.
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COA
| ltems | Standard | Results | |||
| Appearance | White or off-white powder | White powder | |||
| Amino acid analysis | 2-Nal: | 0.9-1.1 | 2-Nal: | 1.0 | |
| 4-Cpa: | 0.9-1.1 | 4-Cpa: | 1.0 | ||
| 3-Pal: | 0.9-1.1 | 3-Pal: | 1.0 | ||
| Ala: | 0.9-1.1 | Ala: | 1.1 | ||
| Tyr: | 0.9-1.1 | Tyr: | 0.9 | ||
| Leu: | 0.9-1.1 | Leu: | 1.1 | ||
| Arg: | 0.9-1.1 | Arg: | 1.0 | ||
| Pro: | 0.9-1.1 | Pro: | 1.0 | ||
| Ser: | Present | Ser: | Present | ||
| MS | 1431.0±1.0 | 1431.1 | |||
| Related Substances | Unspecified impurity for each impurity:NMT1.0% Total impurity:NMT 2.0% |
0.14%(single largest impurity) 0.41% |
|||
| Acetic acid | NMT 15.0% | 6.8% | |||
| Water Content(Karl Fischer) | NMT 7.0% | 4.8% | |||
| Peptide Content(N%) | NLT80% | 88.1% | |||
| Bacterial endotoxins | Less than 5IU/mg | Conforms | |||
| Residual solvent | Methanol:NMT 3000ppm Acetonitrile:NMT410 ppm Triethylamine:NMT 320 ppm |
Conforms | |||
| Conclusion | Conform with enterprise specification | ||||
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Density: 1.4±0.1 g/cm ³
Molecular formula: C70H92ClN17O14
Molecular weight: 1431.038
Precise mass: 1429.669800
PSA 495.67000
LogP 2.69
What is cetrorelix acetate used for?
Cetrorelix Acetate powder is used to prevent premature ovulation as part of controlled ovarian stimulation treatment.
Why is Cetrorelix Acetate used in IVF?
Cetrorelix Acetate is a gonadotropin releasing hormone (GnRH) antagonist that temporarily delays ovulation. It is used to prevent eggs from being released too early and can help your provider be more successful during your egg retrieval procedure.
Does Cetrorelix Acetate have side effects?
Overview: Cetrorelix is used in fertility treatments. Common side effects include pain, discoloration, redness, or swelling at the application site.
What are the pharmacological effects of Cetrorelix acetate?
Cetrorelix Acetate powder is a gonadotropin-releasing hormone (GnRH) antagonist. GnRH can bind to the membrane receptors of pituitary cells. Cetrorelix acetate competitively binds to these receptors with endogenous GnRH, thereby dose-dependently inhibiting the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by the adenopituitary gland. Cetrorelix acetate has an inhibitory effect immediately after administration, and continuous treatment can maintain this inhibitory effect.
For women, Cetrorelix acetate can delay the LH peak, thereby delaying ovulation. For women undergoing ovarian stimulation, the duration of action of Cetrorelix acetate is dose-dependent.
Whether in animals or humans, the effect of Cetrorelix acetate antagonistic hormone can be completely reversed after the treatment ends.
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
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15-60 days |
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Suitable for more than 500kg. |
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