What is Lys-Glu-Asp?
Xi'an Faithful BioTech Co., Ltd. is situated in Xi'an, the birthplace of the ancient Silk Road. Leveraging the city's mature logistics network and abundant fine chemical industrial resources, our enterprise has grown into an integrated fine chemical provider that delivers products to global partners. Lys-Glu-Asp is a synthetic tripeptide with the amino acid sequence Lys-Glu-Asp, belonging to the Havenson short peptide bioregulatory molecular system, and was developed by the St. Petersburg Institute of Bioregulation and Gerontology, Russia. The development of this molecule originated from naturally occurring bioactive peptide fragments in vascular tissue and possesses a well-defined molecular structure. In various laboratory research systems, Vesugen primarily focuses on exploring the mechanisms of vascular endothelial cells, participating in the regulation of intracellular gene expression processes, influencing the activity of vascular wall cells, and helping to maintain the stability of the microcirculation system. Simultaneously, related research continues to explore its interaction with nerve cells, observing the changes this molecule brings to the brain tissue microcirculation environment and cellular plasticity. Currently, the most common form of this raw material is powder, primarily used in in vitro experiments and basic research, and it is a highly regarded research tool in the fields of vascular-related cell biology and aging-related mechanisms.
Application of Lys-Glu-Asp
Lys-Glu-Asp (Vesugen) is widely used in basic research related to in vitro cell culture. This tripeptide is frequently added to vascular endothelial cell culture systems to investigate mechanisms related to cell proliferation, intercellular connections, and endothelial barrier homeostasis, and to observe the impact of gene expression patterns on the physiological state of vascular cells. It is also used in neuronal and neural progenitor cell culture models to study changes in dendritic structure development and synaptic plasticity. In in vitro stem cell culture experiments, this molecule can be used as a research reagent to observe changes in the expression levels of markers related to stem cell senescence and the process of directed differentiation.
COA
| Test Item | Specification | Test Result |
| Appearance | White powder | Complies |
| Purity(HPLC) | ≥98.0% | 98.61% |
| Molecular Mass(MS) | 390.39±0.5 Da | 390.40 Da |
| Amino Acid Sequence | Consistent with Lys-Glu-Asp | Complies |
| Loss on Drying | ≤2.0% | 1.02% |
| Residue on Ignition | ≤0.5% | 0.21% |
| Heavy Metals | ≤10ppm | Conforms |
| Solubility | Soluble in water | Complies |
| Total Plate Count | ≤100 CFU/g | Complies |
| Conclusion | Conform with enterprise specification | |
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The experimental data related to Vesugen (Lys-Glu-Asp, KED tripeptide) mainly come from molecular mechanism studies in in vitro cell culture systems. Molecular simulation experiments show that this tripeptide can bind to the promoter region of the MKI67 gene; in vascular endothelial cell culture systems, it can upregulate Ki-67-related expression levels and simultaneously regulate the expression of endothelin-1 and the gap junction protein Connexin, helping to maintain endothelial cell communication homeostasis and improve cellular physiological state under stress conditions.
Mechanism of action of Lys-Glu-Asp
Gene Regulation
This tripeptide can interact with specific gene promoter regions, regulating the transcriptional levels of multiple functional genes, altering the expression abundance of cell proliferation and homeostasis-related markers, and influencing cellular physiological activities at the transcriptional level.
Regulation of Vascular Endothelial Cell Function
It regulates the expression of endothelial-related signaling proteins, optimizes intercellular communication in endothelial cells, maintains endothelial barrier stability, improves cell survival under external stress, and participates in the regulation of microcirculation-related cellular activities.
Regulating Neural Cell Plasticity
Acting on cultured neurons in vitro, it influences the expression of neuronal marker proteins, enhances dendritic spine-related indices, and participates in the regulation of neural cell structural development and morphological homeostasis.
Participating in the Regulation of Cellular Senescence-Related Pathways
It affects the expression of markers related to cell life cycle, such as SIRT1, p16, and p21, and participates in regulating cellular aging-related processes in in vitro models.
Regulating Signaling Molecule Balance
It regulates the expression levels of signaling molecules such as endothelin and connexins, balancing intercellular signal transduction and creating a more stable cellular microenvironment.
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FAQ
01. In which research scenarios is Lys-Glu-Asp primarily used?
Lys-Glu-Asp is mainly used in basic research related to in vitro cell culture, covering in vitro model experiments of vascular endothelial cells, neurons, and stem cells. It is commonly applied to research on vascular cell mechanisms, neural plasticity, and cell life cycle.
02. What research value does Lys-Glu-Asp possess in neural cell culture experiments?
In in vitro neuronal model experiments, it can regulate the expression of neural markers, increase dendritic spine density, and participate in regulating neural cell structural development. It is a commonly used experimental reagent for studying the mechanisms related to neural cell plasticity and brain microcirculation.
03. What is the commonly used effective concentration range in in vitro experiments?
Most existing publicly available controlled experiments use nanomolar concentration ranges. The appropriate concentration required for different cell models needs further exploration and optimization based on the experimental protocol.
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Statement: This product is only used for scientific research, and the consequences of other uses are not responsible.
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