XEP 018 CAS 936616-33-0

XEP 018 is a sequenced and artificially synthesized biological product that mimics conus toxin. The main chain of XEP-018 consists of 22 amino acids. Its peptide chain is relatively long and has three pairs of disulfide bonds to form its specific spatial three-dimensional structure. Generally, they are small peptides containing 10 to 30 amino acid residues. The vast majority of CTX molecules contain three pairs of disulfide bonds, which are highly folded peptides with strong penetration ability and can achieve a relaxing effect on muscles. Studies on the structural features of XEP-018, such as its disulfide bond connection mode, signal peptide sequence, etc., have found that XEP-018 can block neural signal transmission and inhibit muscle contraction by inhibiting sodium ion channels, calcium ion channels, and acetylcholine receptors, ultimately achieving the effect of reducing wrinkles. XEP-018 can eliminate expression skin wrinkles on the human face and is used in the cosmetics field.

XEP 018 was originally a series of highly specific active peptides for different ion channels and neural receptors secreted by the venom glands on the inner walls of the venom ducts and venom sacs of the Marine gastropod mollusk Conus. XEP-018 is obtained through neuropharmacological design and biological simulation of natural conotoxin. As a regulator of neuromuscular conduction, it selectively blocks the sodium ion valve channels of the muscle type, relaxes the striated muscle, and provides rapid and immediate anti-wrinkle effects. In addition, XEP-018 can retain a certain degree of neuromuscular electrical conduction in the muscles, thereby providing effective muscle relaxation without complete stiffness and paralysis, and achieving a natural anti-wrinkle and anti-wrinkle effect.