Product description
LL-37 Raw Powder is the only human cathelicidin antimicrobial peptide (AMP) encoded by the CAMP gene, serving as a critical component of the innate immune system. This 37-amino acid cationic peptide exhibits broad-spectrum antimicrobial activity alongside remarkable immunomodulatory, wound-healing, and anticancer properties, making it a subject of intense research for developing novel therapeutics against infectious diseases, inflammation, and cancer.
LL-37's amphipathic nature enables it to interact with microbial membranes while maintaining solubility in aqueous environments . The GF-17 region (residues 17-32) constitutes the core antimicrobial domain, responsible for most bactericidal activity.
LL-37 also plays an immunomodulatory role by chemotaxis of immune cells, regulating the secretion of inflammatory pro- and anti-inflammatory factors, and coordinating innate and adaptive immunity. LL-37 can also act on vascular endothelial cells and epithelial cells, stimulating angiogenesis and promoting damage repair. Furthermore, dysregulation of LL-37 expression can lead to various diseases. For example, in psoriasis, elevated LL-37 expression may promote autoimmune responses.
COA
| Test items | Specifications | Results |
| Appearance | White powder | Conforms |
| MS (ESI) | Conforms | Conforms |
| Purity(HPLC) | ≥98.0% | 98.59% |
| Acetate Content(HPLC) | <12.0% | 6.42% |
| Water Content(Karl Fischer) | ≤10.0% | 3.59% |
| Peptide Content(N%) | ≥80.0% | 86.5% |
| Mass Balance | 95.0~105.0% | Conforms |
| Conclusion | Conform with enterprise specification | |
LL-37 Raw Powder is produced by two primary cell types:
Neutrophils: Stored in secondary granules as inactive hCAP-18; released upon activation and cleaved to active LL-37.
Epithelial cells: Expressed constitutively or induced in skin, respiratory tract, gastrointestinal tract, oral mucosa, urogenital tract, and ocular surface.
Therapeutic Potential and Limitations of LL-37 Raw Powder
Its clinical application is currently limited by several challenges, including:
High Cost: Production of the full-length peptide can be expensive.
Proteolytic Degradation: LL-37 is susceptible to breakdown by proteases present in the body, which limits its stability and half-life.
Cytotoxicity: At high concentrations, LL-37 can be toxic to human host cells.
Researchers are developing modified versions and advanced delivery systems, such as nanoparticles, to overcome these limitations and enhance LL-37's therapeutic potential.
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Package
Shipping Methods
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS | Suitable for under 50kg. International door to door express | We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order | |
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
FAQ
01. What is LL-37 raw powder?
LL-37 is a mature peptide composed of 37 amino acids, produced by cleavage of the human cAMP gene precursor protein hCAP-18 by a protease (such as protease-3). It is a positively charged, amphiphilic α-helix peptide widely found in neutrophils, macrophages, epithelial cells, and various tissues and body fluids such as sweat and saliva.
02. What are the main functions of LL-37 raw powder?
LL-37 possesses multiple biological activities:
Broad-spectrum antibacterial activity: It inhibits and kills Gram-positive bacteria, Gram-negative bacteria, fungi, and viruses.
Immunomotor activity: It can regulate inflammatory responses, attracting immune cells (such as neutrophils and monocytes) to the site of infection and neutralizing bacterial endotoxins (LPS), preventing excessive inflammation.
Promoting wound healing: It accelerates tissue repair and angiogenesis by promoting the proliferation and migration of cells such as keratinocytes.
Anti-biofilm activity: It inhibits bacterial biofilm formation, which is crucial for treating chronic infections.
03. How does LL-37 raw powder kill bacteria?
LL-37 raw powder utilizes its cationic properties to preferentially bind to the negatively charged bacterial cell membrane surface. It then inserts into the lipid bilayer, forming transmembrane pores (such as annular pores) or acting as a detergent to disrupt the membrane structure, leading to leakage of bacterial contents and ultimately cell lysis and death.
Disclaimer: All conventional products (non-customized products) pictures are taken in kind, but due to the influence of light (different time, different background light), shooting method, different display equipment parameters and other factors, there may be some differences between the picture and the real color, product color, please take the real effect prevail, product color difference is not a product quality problem.
Note: Always consult a qualified health practitioner before taking any new medication. This product is not intended to diagnose, treat, cure or prevent any disease.At the time of purchase, the international buyer agrees to assume the risk of all items arriving. We cannot replace lost or impounded items. Before sending items, you need to confirm that you agree to these terms.This is only a recommended dose based on our own experience and anecdotal evidence. We recommend that you do your own research before using this product.
Statement: This product is only used for scientific research, and the consequences of other uses are not responsible.
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