Cortagen Peptide

Modern medicine has confirmed that aging is associated with significant changes in gene expression in many organs and tissues. The use of peptide biological modulators in anti-aging therapy holds great promise for correcting age-related changes, making the screening of molecular targets in tissues an important issue in modern gerontology. We obtained the artificially synthesized tetrapeptide Cortagen (Ala-Glu-Asp-Pro) by directional synthesis through amino acid analysis of the natural cortical peptide preparation Cortexin. After preliminary clinical practice, we found that Cortagen peptide powder exhibits significant therapeutic effects on the post-traumatic structural and functional recovery of peripheral nerve tissue. Importantly, other effects were also observed in cardiovascular and cerebrovascular parameters.

What are the studies on Cortagen Peptide?

a) Cortagen and Improving Welfare

Research institutions have confirmed that specific doses of Cortagen peptide powder increase patients' desire to exercise during acute and chronic treatment of anxiety related diseases. There were no adverse reactions to the patient's emotions or emotional characteristics. Researchers have made reverse speculations based on the behavioral logic of depression, suggesting that this stimulating behavior may be beneficial for treating emotional/depressive symptoms. At very low doses, Cortagen can increase patients' well-being, but current data is still insufficient to prove that such efficacy is stable and universal. Therefore, further research is needed to obtain more positive results regarding the benefits to the nervous system.

b) Corticosteroids and neural tissue regeneration and anti-aging

Wuhan University in China has discovered that the peptide biological regulator Cortagen exhibits significant therapeutic effects on the structural and functional regeneration of damaged peripheral nerve tissue. Research on the biological regulation of Cortagen peptide synthesis has shown that it has an impact on both total constitutive heterochromatin and facultative heterochromatin (transcriptional inactive true chromatin). Molecular cytogenetic methods revealed the variability of facultative heterochromatin (FH) in cultured lymphocytes of the tested individuals. Cortagen induces total heterochromatin de heterochromatin (de condensation), activating the synthesis process of ribosomal genes through de heterochromatin near the centromere chromosome satellite stalk, without inducing heterochromatin de condensation around the centromere structure, and releasing inhibitory genes caused by the condensation of the euchromatin region that forms FH. These findings indicate that Cortagen can protect and regenerate neural tissue while preventing its aging.

c)Cortagen and myocardial cell protection

Laboratory studies on the effects of Ala-Glu-Asp-Pro have demonstrated its positive role in myocardial protection. In addition to other effects, the peptide also increased the expression of the heat shock protein Hsc70, which is crucial for protecting the myocardium, regulated the expression of Bmp2 and Wnt4 genes involved in programmed cell death and cardiac tissue formation, and enhanced the cardiac expression of subtype 15 epidermal growth factor receptor (Eps15) and its related sequences (Eps15 rs), which regulate mitotic signaling, normal proliferation, and cancerous proliferation.

What are the reasons why Cortagen Peptide supports brain function and repair process?

According to the existing experimental data, scientists believe that CORTAGEN ALA-GLU-ASP-PRO (AEDP) activates the brain repair process and enhances brain activity, supporting the treatment and prevention of neurodegenerative brain diseases for the following reasons:
1. Influence on translation and transcription mechanism: Cortagen affects the expression of genes encoding structural proteins and enzyme proteins, regulates the repair process of neurons and the synthesis of protein necessary for the normal operation of nerve cells, such as heat shock protein (HSP).

2. Eliminating harmful free radicals: Cortagen, as a free radical scavenger, protects the lipid, protein and DNA in neurons from oxidative damage.

3. Prevention of apoptosis: Cortagen, as an inhibitor of caspase, can reduce its activity, thus preventing apoptosis and protecting cells in the nervous system. In addition, Cortagen peptide can also regulate the level of Bcl-2 protein and provide dual anti-apoptosis effects.

4. Stimulate neurogenesis: Ala-Glu-Asp-Pro supports neurogenesis, that is, the process of forming new neurons. Cortagen promotes the growth of progenitor cells and synapses, thus promoting the repair of brain injury.

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