What is GHK-Cu Peptide?
GHK-Cu Peptide is an endogenous tripeptide-copper complex raw material, appearing as a blue powder or crystalline powder. Its CAS number is 49557-75-7. This product is a complex of a tripeptide and copper ions naturally found in human blood plasma, saliva, and urine. Its sequence is Gly-His-Lys-Cu. GHK-Cu Peptide primarily functions to promote wound healing, has anti-inflammatory and antioxidant effects, stimulates collagen synthesis, promotes hair growth, and aids in tissue repair, and has wide applications in cosmetics, skin care, and biomedical research.
How GHK-Cu Peptide regulates skin repair and anti-aging metabolic pathways?
GHK-Cu Peptide is a core active peptide in the fields of bio-skincare and skin research, possessing triple bioactivities of repair, anti-oxidation, and anti-inflammation. It can penetrate the skin's surface barrier, reaching the dermis to regulate cell metabolism and matrix synthesis. In raw material applications, it is primarily used for anti-aging repair, barrier repair, and the development of skincare ingredients to soothe sensitive skin. It can also be used for scalp repair, improving scalp aging and microenvironmental imbalance. In research, it is widely used in experiments on skin oxidative stress, wound healing mechanisms, fibroblast activity regulation, and verification of skin aging mechanisms. Overall, it is suitable for various scenarios including bio-cosmetics R&D, biomedical skin repair projects, and peptide activity research.
How does GHK-Cu Peptide achieve anti-inflammatory, antioxidant, and collagen synthesis-promoting effects?
The core mechanism of action of GHK-Cu Peptide involves a synergistic effect of anti-inflammation, anti-oxidation, and promotion of extracellular matrix synthesis. Regarding anti-inflammation, recent studies have shown that this peptide can exert a significant anti-inflammatory effect in a zebrafish acute inflammation model by regulating the JAK1-STAT3 signaling pathway, reducing the production of pro-inflammatory cytokines. In terms of anti-oxidation, GHK-Cu Peptide has been found to target and bind to peroxide reductase 6, thereby alleviating oxidative stress-induced cell damage. Regarding tissue repair and regeneration, this peptide can act as an activator of tissue remodeling, signaling macrophage migration to damaged sites, releasing growth factors to stimulate hair follicles, and significantly promoting the synthesis of collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts, while accelerating the degradation of abnormal collagen aggregates in scar tissue.
MF of GHK-Cu Peptide
CAS：49557-75-7
Molecular Formula: C14H24CuN6O4
Molecular Weight: 448.93 g/mol
Storage conditions: -20℃
Sequence: Gly-His-Lys-Cu
Product Specification
| Item | Specification | Result |
| Appearance | Blue crystalline powder | Complies |
| Identification | IR/HPLC consistent with standard | Complies |
| Single Impurity | ≤0.5% | 0.21% |
| Purity | ≥98.0% | 98.25% |
| Loss on Drying | ≤5.0% | 2.85% |
| Water Content | ≤ 5.0% | 3.20% |
| Heavy Metals | ≤ 20 ppm | Complies |
| Conclusion | Complies with enterprise standard | |
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FAQ：
Q1: What is the core anti-aging mechanism of GHK-Cu Peptide?
A1: It activates dermal fibroblast activity, promotes collagen and elastin synthesis, plumps the skin structure, delays skin aging, and reduces fine lines and sagging.
Q2: How does it achieve skin repair and stabilization effects?
A2: It regulates skin inflammation expression, accelerates the repair of damaged epidermal tissue, strengthens the skin barrier structure, and improves skin problems such as sensitivity, redness, and a fragile barrier.
Q3: Where does the antioxidant physiological effect of GHK-Cu Peptide manifest itself?
A3: It effectively removes excess free radicals from the skin, reduces oxidative stress damage to cells, reduces skin aging damage caused by the external environment, and maintains a healthy cellular state.
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